PLUS Loyola Clinical Center

项目总结： Plus旨在对膀胱健康研究产生持续、强大的影响。Loyola临床 中心(LCC)是第一个资助周期中PLUS研究活动的有力贡献者，因为我们 社区参与方面的专门知识，包括与在健康方面表现不佳的队列建立伙伴关系 研究。在这一更新应用中，LCC带来了评估尿路疾病的额外的、罕见的专业知识 微生物组(尿生物组)，这与健康膀胱的生物调节功能有关。基于 基础研究在第一个资助期完成，我们的研究人员渴望利用我们的资源 以及我们不断增长的专业知识，以推进Plus使命，并继续我们的协作工作。我们的运输- 学科研究团队将通力合作，朝着我们推进膀胱的总体目标努力 健康。在这次续签申请中，通过三个具体目标，我们计划进行高影响力的研究， 挑战现有范式，改进膀胱健康研究方法，重点放在 肌肉骨骼干预和尿路生物组研究。这些目标包括(SA1)确定关系 (SA2)通过战略性收集、分析和评估生命阶段的肌肉骨骼和膀胱健康状况 以证据为基础的尿液生物检疫储存，评估自我收集和潜在运输的有效性 参与者，评估基线和纵向尿菌群特征，重点是以下特征 随着时间的推移与膀胱健康和LUTS发展相关，并建立高质量的尿路生物群 一旦新的启动子和膀胱健康的风险因素被确定后，用于后续分析的生物储存库 确定并(SA3)通过整合社区增强Plus社区参与的研究 利益攸关方作为联合调查员，并设计促进这一整合的流程。此外，有限责任公司将 有助于最终设计、实施和分析以美国人口为基础的大型观察队列 使用PLUS开发和验证的膀胱健康仪器，对整个生命周期的妇女进行测试。在 这项研究，LCC建议通过收集研究健康膀胱的生物调节功能 以及尿样分析，重点关注尿微生物组(尿菌组)的健康状况。LCC一直处于活动状态 在向社区、其他研究人员和临床医生(在适当情况下)传播PLUS工作的过程中，以及 病人。除了生成新的数据和研究工具外，我们预计还将建立一个 为将来的研究提供生物样本。作为PLUS研究联盟的一个组成部分，我们预计 我们中心的目标是迅速提高科学知识和LUTS预防策略 已实现。这些改进将使更广泛的研究界受益并得到支持，产生特别的影响 关于更广泛的泌尿科社区和妇女健康。我们的继续工作将进一步推进现有的工作 LUTS预防和膀胱健康改善人类健康的基础证据。

PROJECT SUMMARY: PLUS was designed to exert a sustained, powerful influence on bladder health research. The Loyola Clinical Center (LCC) was a robust contributor to PLUS research activities in the first funding cycle, due to our significant expertise in Community Engagement, including partnerships with cohorts that are poorly represeted in health research. In this renewal application, the LCC brings additional, rare expertise in evaluation of the urinary microbiome (urobiome), which is related to the bioregulatory function of the healthy bladder. Based on the foundational research accomplished in the first funding period, our investigators are eager to utilize our resources and our growing expertise to advance the PLUS mission, and continue our collaborative work. Our trans- disciplinary team of researchers will work collaboratively toward the our over-arching goal of advancing bladder health. In this renewal application, through three specific aims, we plan to conduct high-impact research that challenge existing paradigms and improve research approaches in bladder health, with a focus on musculoskeletal interventions and urobiome research. These aims include (SA1) To determine the relationship of musculoskeletal and bladder health across the life stages, (SA2) Through strategic collection, analysis and evidence-based storage of urine biospecimens, assess validity of self-collection and shipping from potential participants, assess the baseline and longitudinal urobiome characteristics, with focus on characteristics that are associated with bladder health and LUTS development over time and establish a high-quality urobiome biorepository for subsequent analysis, once novel promoters and risk factors for bladder health have been identified and (SA3) enhance PLUS Consortium community engaged research by integrating community stakeholders as co-investigators and designing processes that facilitate this integration. In addition, the LLC will contribute to the final design, conduct and analysis of a large, US population-based observational cohort of women across the life-span, using the Bladder Health Instrument which PLUS developed and validated. Within this study, the LCC proposes investigation of the bioregulatory functions of the healthy bladder through collection and anaysis of urine speciments, focusing on urinary microbiome (urobiome) health. The LCC has been active in the dissemination of PLUS work to the community, other researchers, and – when appropriate - clinicians, and patients. In addition to generating novel data and research tools, we anticipate establishing a repository of biological samples for future studies. As an integral component of the PLUS Research Consortium, we expect rapid improvements in scientific knowledge and LUTS prevention strategies as the aims of our Center are achieved. These improvements will benefit and support the broader research community with particular impact on the broader urology community and women’s health. Our continued work will further advance exising foundational evidence for LUTS prevention and bladder health to improve human health.