PLUS Loyola Clinical Center

项目概要： PLUS旨在对膀胱健康研究产生持续，强大的影响。洛约拉临床 中心（LCC）是PLUS研究活动在第一个资助周期的一个强大的贡献者，由于我们的重大 社区参与方面的专业知识，包括与健康状况较差的人群建立伙伴关系 research.在这次更新申请中，LCC带来了额外的，罕见的泌尿系统评估专业知识。 微生物组（尿生物组），其与健康膀胱的生物调节功能有关。基于 在第一个资助期内完成的基础研究，我们的研究人员渴望利用我们的资源 和我们不断增长的专业知识，以推进PLUS的使命，并继续我们的合作工作。我们的跨- 一个由研究人员组成的学科团队将共同努力，实现我们的超预期目标， 健康在这次更新申请中，通过三个具体目标，我们计划进行高影响力的研究， 挑战现有的范式，改善膀胱健康的研究方法，重点是 肌肉骨骼干预和泌尿系统研究。这些目标包括（SA 1）确定关系 的肌肉骨骼和膀胱健康在整个生命阶段，（SA 2）通过战略收集，分析和 尿液生物标本的循证储存，评估自我采集和从潜在的 参与者，评估基线和纵向尿生物群系特征，重点关注 与膀胱健康和LUTS发展相关，并建立高质量的尿生物群系 一旦发现膀胱健康的新启动子和风险因素， 确定并（SA 3）通过整合社区来加强PLUS Consortium社区参与的研究 利益攸关方作为共同调查者，并设计促进这种整合的流程。此外，LLC将 有助于最终设计，进行和分析一个大的，美国人口为基础的观察队列， 使用PLUS开发和验证的膀胱健康工具，对女性进行终身随访。内 在这项研究中，LCC建议通过收集健康膀胱的生物调节功能， 和尿液排泄物分析，重点关注尿微生物组（urobiome）健康。LCC一直在积极 向社区、其他研究人员和（适当时）临床医生传播PLUS工作，以及 患者除了生成新的数据和研究工具外，我们还希望建立一个 生物样本用于未来研究。作为PLUS研究联盟的一个组成部分，我们希望 快速提高科学知识和LUTS预防策略，作为我们中心的目标是 办妥了一批这些改进将有利于和支持更广泛的研究界，并产生特别的影响 对更广泛的泌尿学社区和女性健康的影响。我们的持续工作将进一步推动 LUTS预防和膀胱健康的基础证据，以改善人类健康。

PROJECT SUMMARY: PLUS was designed to exert a sustained, powerful influence on bladder health research. The Loyola Clinical Center (LCC) was a robust contributor to PLUS research activities in the first funding cycle, due to our significant expertise in Community Engagement, including partnerships with cohorts that are poorly represeted in health research. In this renewal application, the LCC brings additional, rare expertise in evaluation of the urinary microbiome (urobiome), which is related to the bioregulatory function of the healthy bladder. Based on the foundational research accomplished in the first funding period, our investigators are eager to utilize our resources and our growing expertise to advance the PLUS mission, and continue our collaborative work. Our trans- disciplinary team of researchers will work collaboratively toward the our over-arching goal of advancing bladder health. In this renewal application, through three specific aims, we plan to conduct high-impact research that challenge existing paradigms and improve research approaches in bladder health, with a focus on musculoskeletal interventions and urobiome research. These aims include (SA1) To determine the relationship of musculoskeletal and bladder health across the life stages, (SA2) Through strategic collection, analysis and evidence-based storage of urine biospecimens, assess validity of self-collection and shipping from potential participants, assess the baseline and longitudinal urobiome characteristics, with focus on characteristics that are associated with bladder health and LUTS development over time and establish a high-quality urobiome biorepository for subsequent analysis, once novel promoters and risk factors for bladder health have been identified and (SA3) enhance PLUS Consortium community engaged research by integrating community stakeholders as co-investigators and designing processes that facilitate this integration. In addition, the LLC will contribute to the final design, conduct and analysis of a large, US population-based observational cohort of women across the life-span, using the Bladder Health Instrument which PLUS developed and validated. Within this study, the LCC proposes investigation of the bioregulatory functions of the healthy bladder through collection and anaysis of urine speciments, focusing on urinary microbiome (urobiome) health. The LCC has been active in the dissemination of PLUS work to the community, other researchers, and – when appropriate - clinicians, and patients. In addition to generating novel data and research tools, we anticipate establishing a repository of biological samples for future studies. As an integral component of the PLUS Research Consortium, we expect rapid improvements in scientific knowledge and LUTS prevention strategies as the aims of our Center are achieved. These improvements will benefit and support the broader research community with particular impact on the broader urology community and women’s health. Our continued work will further advance exising foundational evidence for LUTS prevention and bladder health to improve human health.