PLUS Loyola Clinical Center

 描述(由申请人提供)：PLUS Loyola临床中心(PLUS-LCC)是一个组织良好、经验丰富的协作团队，旨在为PLUS网络的目标做出强有力的贡献。凭借深度和广度的研究专业知识，PLUS-LCC计划进行四项综合良好的研究，以映射到LUTS影响的相互依赖的生态水平，并便于检查研究内和跨研究对风险和保护因素的考虑。PLUS-LCC将通过使用重叠的研究参与者子样本和混合方法学方法来优化这些有价值的研究队列。在建议的PLUS-LCC研究中，我们将通过参与全芝加哥范围的参与性、混合方法的基于社区的骨盆健康评估来探索社区、文化背景，通过进行第一次芝加哥LUTS和社区健康调查，第一次对社区成员骨盆健康感知、行为和知识群体的大规模定性研究，并进行景观评估，以表征芝加哥妇女参与的医疗保健系统。PLUS-LCC还将通过研究尿液微生物组的变异性和个人行为的比较，检查个人层面的影响和行为，评估下腰痛和背部疼痛的肌肉骨骼千分点，以确定其与LUTS的关联；并调查关系层面的影响，以确定LUTS讨论模式，垂直于世代，水平于同龄人。作为PLUS的强大贡献者，洛约拉临床中心在研究概念、设计、实施、分析和传播方面提供专业知识。我们的协作方法将有助于发挥其他PLUS调查人员的最佳能力，就像他们对我们一样。PLUS网络有机会在长期未被研究的LUTS预防作用方面取得进展。

 DESCRIPTION (provided by applicant): The PLUS Loyola Clinical Center (PLUS-LCC) is a well-organized, experienced, collaborative team that has been designed to robustly contribute to the goals of the PLUS network. With depth and breadth of research expertise, PLUS-LCC plans four, well- integrated studies that map onto an interdependent ecological level of LUTS influence and facilitate examination of within-study and cross-study consideration of risk and protective factors. The PLUS-LCC will optimize these valuable research cohorts through the use of an overlapping subsample of study participants and mixed-methodological approaches. In the proposed PLUS-LCC studies, we will explore the community, cultural context by engaging in a Chicago-wide participatory, mixed methodological community-based Pelvic Health Assessment by conducting the first Chicago LUTS and community health survey, first large scale qualitative study on community members pelvic health perceptions, behaviors and knowledge groups, and conduct landscape assessment to characterize Chicago's health care system where women interface. PLUS-LCC will also examine individual-level influences and behavior through the study of urinary microbiome variability and comparison of individual behaviors, assess musculoskeletal milleu in lower-and back pain to determine its association with LUTS; and investigate relationship-level influence to locate LUTS discussion patterns, vertically among generations and horizontally among peers. As a strong contributor for PLUS, the Loyola Clinical Center contributes expertise in study concept, design, conduct, analysis and dissemination. Our collaborative approach will help bring out the best in other PLUS investigators, as they will for us. The PLUS network has the opportunity to make advances in the long understudied role of LUTS prevention.