The Female Urinary Microbiome and Urinary Incontinence

 描述(由申请人提供)：我们将确定新发现的女性尿路微生物群的关键特征是否与两种常见的尿失禁形式(压力性尿失禁[SUI]和紧迫性尿失禁[UUI])密切相关。为了进行这项研究，Loyola研究人员将招募大约1200名女性(从两个具有良好特征的尿失禁队列和400名大小便失禁对照中各招募400名)。他们将确定某些细菌种类或整个微生物群是否与尿失禁症状有关。这些临床亚组之间的显著差异将提示尿失禁与女性尿路微生物群(FUM)之间的关系。将研究一种具有抗菌性能的FUM成员。我们的团队拥有不同的专业知识，包括专门从事尿失禁护理的临床医生，以及专门从事微生物学和生物信息学的科学家。

 DESCRIPTION (provided by applicant): We will determine whether key characteristics of the newly discovered female urinary microbiome, the bacterial community living in the bladder of many adult women, associate strongly with two common forms of urinary incontinence (stress urinary incontinence [SUI] and urgency urinary incontinence [UUI]). To perform this study, Loyola investigators will recruit approximately 1200 women (400 each from two, well- characterized urinary incontinence cohorts and 400 continent controls). They will determine whether certain bacterial species, or entire microbiomes, are related to urinary incontinence symptoms. A significant difference between these clinical subgroups would suggest a relationship between urinary incontinence and the female urinary microbiome (FUM). One FUM member with antibacterial properties will be studied. Our team has diverse expertise including clinicians specializing in urinary incontinence care, and scientists specializing in microbiology and bioinformatics.