Urinary Bacterial Communities in Urge Incontinence Women

描述（由申请人提供）：尿急性尿失禁（UUI）是伴随尿急或尿急之前的非自愿性尿失禁。虽然UUI似乎涉及控制排尿的神经通路，但病因尚不完全清楚。我们的突破性发现清楚地表明，女性人类膀胱不是无菌的，尽管阴性尿培养状态的基础上，我们提出了新的假设，下尿路的细菌定植影响UUI症状，并概述实验来验证这一假设。如果我们的研究结果支持我们的假设，我们将提供新的见解UUI病因。如果细菌群落结构与UUI相关，则可以靶向治疗以改变该细菌群落。这样的研究将有直接的临床影响，并将非常适合美国国立卫生研究院赞助的临床试验网络。

DESCRIPTION (provided by applicant): Urgency urinary incontinence (UUI) is involuntary leakage accompanied by or immediately preceded by urgency. While UUI appears to involve the neural pathways that control micturition, the etiology is incompletely understood. On the basis of our groundbreaking findings that clearly show that female human bladders are not sterile despite negative urine culture status, we propose the novel hypothesis that bacterial colonization of the lower urinary tract influences UUI symptoms and outline experiments to test this hypothesis. If our findings support our hypothesis, we will have provided novel insights into UUI etiology. If bacterial community structure correlates with UUI, then treatments could be targeted to modify this bacterial community. Such studies would have immediate clinical impacts and would be well suited for NIH- sponsored clinical trials networks.