Urinary Bacterial Communities in Urge Incontinence Women

描述（由申请人提供）：急迫性尿失禁（UUI）是伴随急迫性或紧接在急迫性之前的非自愿尿漏。虽然UUI似乎涉及控制排尿的神经通路，但其病因尚不完全清楚。我们的突破性发现清楚地表明，尽管尿液培养阴性，但女性膀胱并非无菌，我们提出了下尿路细菌定植影响UUI症状的新假设，并概述了验证这一假设的实验。如果我们的发现支持我们的假设，我们将为UUI病因学提供新的见解。如果细菌群落结构与UUI相关，那么治疗可以靶向修饰这种细菌群落。这样的研究将有直接的临床影响，将非常适合美国国立卫生研究院资助的临床试验网络。

DESCRIPTION (provided by applicant): Urgency urinary incontinence (UUI) is involuntary leakage accompanied by or immediately preceded by urgency. While UUI appears to involve the neural pathways that control micturition, the etiology is incompletely understood. On the basis of our groundbreaking findings that clearly show that female human bladders are not sterile despite negative urine culture status, we propose the novel hypothesis that bacterial colonization of the lower urinary tract influences UUI symptoms and outline experiments to test this hypothesis. If our findings support our hypothesis, we will have provided novel insights into UUI etiology. If bacterial community structure correlates with UUI, then treatments could be targeted to modify this bacterial community. Such studies would have immediate clinical impacts and would be well suited for NIH- sponsored clinical trials networks.