The Female Urinary Microbiome and Urinary Incontinence
女性泌尿微生物组和尿失禁
基本信息
- 批准号:9246520
- 负责人:
- 金额:$ 64.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-04-01 至 2021-03-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAdverse eventAffectAnti-Bacterial AgentsAntibiotic TherapyAntibioticsBacteriaBehavior TherapyBioinformaticsBladderCaringCathetersCharacteristicsClinicalCommunitiesDataData AnalysesDevelopmentEtiologyEvaluationFemaleFundingIndividualInfectionInstitutesInterventionLactobacillusMedicalMicrobiologyMorbidity - disease rateNational Institute of Child Health and Human DevelopmentNational Institute of Diabetes and Digestive and Kidney DiseasesOperative Surgical ProceduresParticipantPatientsPelvic Floor DisordersPharmacological TreatmentPlayPreparationPreventionPricePropertyProtocols documentationQuality of lifeRecruitment ActivityRequest for ProposalsResearchResearch PersonnelResourcesRestRiskRoleSamplingScientific InquiryScientistSignal TransductionSterilityStress Urinary IncontinenceSubgroupSymptomsTechniquesTestingTimeUnited States National Institutes of HealthUrethral sphincterUrge IncontinenceUrinary IncontinenceUrinary tractUrinary tract infectionUrineUropathogenUropathogenic E. coliWomancohortcommunity livingexperienceimprovedincontinence symptominsightkillingslower urinary tract symptomsmembermicrobiomemicrobiotamicturition urgencyneuromuscular functionnovelpathogenpreventpublic health relevancerRNA Genesresponseurinary
项目摘要
DESCRIPTION (provided by applicant): We will determine whether key characteristics of the newly discovered female urinary microbiome, the bacterial community living in the bladder of many adult women, associate strongly with two common forms of urinary incontinence (stress urinary incontinence [SUI] and urgency urinary incontinence [UUI]). To perform this study, Loyola investigators will recruit approximately 1200 women (400 each from two, well- characterized urinary incontinence cohorts and 400 continent controls). They will determine whether certain bacterial species, or entire microbiomes, are related to urinary incontinence symptoms. A significant difference between these clinical subgroups would suggest a relationship between urinary incontinence and the female urinary microbiome (FUM). One FUM member with antibacterial properties will be studied. Our team has diverse expertise including clinicians specializing in urinary incontinence care, and scientists specializing in microbiology and bioinformatics.
描述(由申请人提供):我们将确定新发现的女性尿液微生物组的关键特征,即生活在许多成年女性膀胱中的细菌群落,是否与两种常见形式的尿失禁(压力性尿失禁[SUI]和紧迫性尿失禁[UUI])密切相关。为了进行这项研究,洛约拉研究人员将招募大约1200名妇女(400名来自两个,特征良好的尿失禁队列和400名大陆对照)。他们将确定某些细菌物种或整个微生物组是否与尿失禁症状有关。这些临床亚组之间的显著差异表明尿失禁与女性尿液微生物组(FUM)之间的关系。将研究具有抗菌性能的FUM成员。我们的团队拥有各种专业知识,包括专门从事尿失禁护理的临床医生,以及专门从事微生物学和生物信息学的科学家。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LINDA BRUBAKER其他文献
LINDA BRUBAKER的其他文献
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{{ truncateString('LINDA BRUBAKER', 18)}}的其他基金
The Female Urinary Microbiome and Urinary Incontinence
女性泌尿微生物组和尿失禁
- 批准号:
9899229 - 财政年份:2016
- 资助金额:
$ 64.36万 - 项目类别:
The Female Urinary Microbiome and Urinary Incontinence
女性泌尿微生物组和尿失禁
- 批准号:
9028341 - 财政年份:2016
- 资助金额:
$ 64.36万 - 项目类别:
The Female Urinary Microbiome and Urinary Incontinence
女性泌尿微生物组和尿失禁
- 批准号:
9074683 - 财政年份:2015
- 资助金额:
$ 64.36万 - 项目类别:
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