女性泌尿微生物组和尿失禁-猫眼课题宝

女性泌尿微生物组和尿失禁

批准号：

9899229

负责人：

LINDA BRUBAKER

金额：

$59.36万

依托单位：

LOYOLA UNIVERSITY CHICAGO

依托单位国家：

美国

项目类别：

财政年份：

2016

资助国家：

美国

项目状态：

已结题

起止时间：

2016-04-01 至 2022-03-31

来源：

https://reporter.nih.gov/project-details/9899229

关键词：

16S ribosomal RNA sequencing Adult Adverse event Affect Anti-Bacterial Agents Antibiotic Therapy Antibiotics Bacteria Behavior Therapy Bioinformatics Bladder Caring Catheters Characteristics Clinical Data Data Analyses Development Etiology Evaluation Female Funding Individual Infection Institutes Intervention Lactobacillus Medical Microbiology Morbidity - disease rate National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases Operative Surgical Procedures Patient Recruitments Patients Pelvic Floor Disorders Pharmacological Treatment Play Preparation Prevention Price Property Protocols documentation Quality of life Request for Proposals Research Research Personnel Resources Rest Risk Role Sampling Scientific Inquiry Scientist Signal Transduction Sterility Stress Urinary Incontinence Subgroup Symptoms Techniques Testing Time United States National Institutes of Health Urethral sphincter Urge Incontinence Urinary Incontinence Urinary Microbiome Urinary tract Urinary tract infection Urine Uropathogen Uropathogenic E. coli Woman bacterial community bacteriome cohort community living experience improved incontinence symptom insight lower urinary tract symptoms microbiome microbiome alteration microbiome components microbiome composition microbiota micturition urgency neuromuscular function novel pathogen prevent public health relevance recruit response urinary

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DESCRIPTION (provided by applicant): We will determine whether key characteristics of the newly discovered female urinary microbiome, the bacterial community living in the bladder of many adult women, associate strongly with two common forms of urinary incontinence (stress urinary incontinence [SUI] and urgency urinary incontinence [UUI]). To perform this study, Loyola investigators will recruit approximately 1200 women (400 each from two, well- characterized urinary incontinence cohorts and 400 continent controls). They will determine whether certain bacterial species, or entire microbiomes, are related to urinary incontinence symptoms. A significant difference between these clinical subgroups would suggest a relationship between urinary incontinence and the female urinary microbiome (FUM). One FUM member with antibacterial properties will be studied. Our team has diverse expertise including clinicians specializing in urinary incontinence care, and scientists specializing in microbiology and bioinformatics.

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