The Female Urinary Microbiome and Urinary Incontinence

女性泌尿微生物组和尿失禁

• 批准号: 9899229
• 负责人: LINDA BRUBAKER
• 金额: $ 59.36万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9899229
• 关键词: 16S ribosomal RNA sequencing; Adult; Adverse event; Affect; Anti-Bacterial Agents; Antibiotic Therapy; Antibiotics; Bacteria; Behavior Therapy; Bioinformatics; Bladder; Caring; Catheters; Characteristics; Clinical; Data; Data Analyses; Development; Etiology; Evaluation; Female; Funding; Individual; Infection; Institutes; Intervention; Lactobacillus; Medical; Microbiology; Morbidity - disease rate; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Operative Surgical Procedures; Patient Recruitments; Patients; Pelvic Floor Disorders; Pharmacological Treatment; Play; Preparation; Prevention; Price; Property; Protocols documentation; Quality of life; Request for Proposals; Research; Research Personnel; Resources; Rest; Risk; Role; Sampling; Scientific Inquiry; Scientist; Signal Transduction; Sterility; Stress Urinary Incontinence; Subgroup; Symptoms; Techniques; Testing; Time; United States National Institutes of Health; Urethral sphincter; Urge Incontinence; Urinary Incontinence; Urinary Microbiome; Urinary tract; Urinary tract infection; Urine; Uropathogen; Uropathogenic E. coli; Woman; bacterial community; bacteriome; cohort; community living; experience; improved; incontinence symptom; insight; lower urinary tract symptoms; microbiome; microbiome alteration; microbiome components; microbiome composition; microbiota; micturition urgency; neuromuscular function; novel; pathogen; prevent; public health relevance; recruit; response; urinary

 DESCRIPTION (provided by applicant): We will determine whether key characteristics of the newly discovered female urinary microbiome, the bacterial community living in the bladder of many adult women, associate strongly with two common forms of urinary incontinence (stress urinary incontinence [SUI] and urgency urinary incontinence [UUI]). To perform this study, Loyola investigators will recruit approximately 1200 women (400 each from two, well- characterized urinary incontinence cohorts and 400 continent controls). They will determine whether certain bacterial species, or entire microbiomes, are related to urinary incontinence symptoms. A significant difference between these clinical subgroups would suggest a relationship between urinary incontinence and the female urinary microbiome (FUM). One FUM member with antibacterial properties will be studied. Our team has diverse expertise including clinicians specializing in urinary incontinence care, and scientists specializing in microbiology and bioinformatics.



项目成果

Urinary microbiota of women with recurrent urinary tract infection: collection and culture methods.

• DOI: 10.1007/s00192-021-04780-4
• 发表时间: 2022-03
• 期刊: International urogynecology journal
• 影响因子: 1.8
• 作者: Hochstedler BR;Burnett L;Price TK;Jung C;Wolfe AJ;Brubaker L
• 通讯作者: Brubaker L

Impact of intravesical Bacillus Calmette-Guérin and chemotherapy on the bladder microbiome in patients with non-muscle invasive bladder cancer.

• DOI: 10.3389/fcimb.2023.1125809
• 发表时间: 2023
• 期刊: Frontiers in cellular and infection microbiology
• 影响因子: 5.7

Recurrent urinary tract infection: Association of clinical profiles with urobiome composition in women.

• DOI: 10.1002/nau.24707
• 发表时间: 2021-08
• 期刊: Neurourology and urodynamics
• 影响因子: 2
• 作者: Burnett LA;Hochstedler BR;Weldon K;Wolfe AJ;Brubaker L
• 通讯作者: Brubaker L

Whole-Genome Sequencing of Staphylococcus aureus and Staphylococcus haemolyticus Clinical Isolates from Egypt.

• DOI: 10.1128/spectrum.02413-21
• 发表时间: 2022-08-31
• 期刊: Microbiology spectrum
• 影响因子: 3.7

First trimester "clean catch" urine and vaginal swab sample distinct microbiological niches.

• DOI: 10.1128/spectrum.02638-23
• 发表时间: 2024-01-11
• 期刊: Microbiology spectrum
• 影响因子: 3.7