Health Outcomes in Blood Donors and Recipients

献血者和受血者的健康结果

• 批准号: 8270509
• 负责人: EDWARD L MURPHY
• 金额: $ 17.86万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-05 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8270509
• 关键词: Adult; Age; Alveolar; Area; Arthritis; Autoimmune Diseases; Autoimmune Process; Biological; Blood; Blood Transfusion; Blood donor; Bronchitis; Cardiovascular system; Clinical; Collaborations; Complete Blood Count; Consultations; Death Rate; Developing Countries; Diagnosis; Doctor of Philosophy; Enrollment; Epidemiologist; Faculty; Funding; Generations; Genetic; Grant; Health; Human T-lymphotropic virus 1; Human T-lymphotropic virus 2; Immune; Incidence; Infection; Infective cystitis; Institutes; International; Investigation; Irrigation; Joints; Laboratories; Lead; Lung; Lymphocyte; Malignant - descriptor; Malignant Neoplasms; Measures; Medicine; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Monitor; Outcome; Outcome Study; Pathogenesis; Peripheral Blood Mononuclear Cell; Persons; Physicians; Pneumonia; Population; Postdoctoral Fellow; Prevalence; Public Health Schools; Questionnaires; Recurrence; Research; Research Activity; Research Personnel; Research Support; Research Training; Rheumatology; SECTM1 gene; Safety; Scientist; Screening procedure; Specimen; Spinal Cord Diseases; T-Cell Leukemia; Time; Toxic effect; Training; Training Activity; Transfusion; Transfusion-Transmitted Virus; United States National Institutes of Health; Venous blood sampling; Visit; Wages; World Health Organization; base; career; cohort; cytokine; genetic epidemiology; global health; graduate student; improved; international center; mortality; novel; patient oriented research; programs; repository; sex; virus genetics

Dr. Murphy is a well-established, well-funded and productive researcher who has productively utilized the K24 mechanism during the first funding period to leverage his participation in patient oriented research (POR) and to devote substantial additional time to training and mentoring. He has been successful in traditional mentoring of graduate students, fellows and junior faculty towards their own career in POR. More novel, but still fully within the scope of the K24 award's intent, he has instituted a dynamic new program in POR training for transfusion medicine MD's and PhD's in developing countries that will lead to a new generation of researchers devoted to improving the safety and availability of blood transfusion on a worldwide basis. Finally, there are still competing demands for time and funded salary between research and training activities and remaining commitments to administrative duties. Although medium-long term mentorship has been successful, the international program is still young and the applicant would like more time for several promising trainees from the short course to transition to medium to long term mentorship. An additional five years of funding is requested to enable the formation of a Center of Excellence in POR training in international transfusion safety: ¿ Continue and expand his program of high quality POR, with a research concentration on the health outcomes of transfusion transmitted viruses and genetic epidemiology. ¿ Continue and increase medium- and long-term mentorship under the umbrella of the UCSF CTSI, UC Berkeley School of Public Health and the new roadmap K12 Masters and Ph.D. programs at UCSF. ¿ Expand and obtain independent funding for international training activities, in collaboration with the UCSF Institute for Global Health, and NIH Fogarty International Center training grants ¿ Further strengthen his own research team, promoting the independence of junior faculty and a joint (UCSF and BSRI) recruitment of a genetic epidemiologist to aid the laboratory's expansion into this new area of research.

Murphy博士是一位地位稳固、资金充足且富有成效的研究人员，他在第一个资助期内有效地利用了K24机制，以充分利用他对患者导向研究（POR）的参与，并将大量额外的时间用于培训和指导。他一直成功地在传统的指导研究生，研究员和初级教师对自己的职业生涯在POR。更新颖，但仍然完全在K24奖的意图范围内，他为发展中国家的输血医学博士和博士制定了一个充满活力的POR培训新计划，这将导致新一代的研究人员致力于提高全球输血的安全性和可用性。最后，研究和培训活动与剩余的行政职责之间仍然存在对时间和资金工资的竞争需求。虽然中长期导师制已经取得了成功，但国际项目仍然很年轻，申请人希望有更多的时间让几个有前途的学员从短期课程过渡到中长期导师制。要求额外提供五年的资金，以建立国际输血安全POR培训卓越中心： 继续并扩大他的高质量POR计划，重点研究输血传播病毒和遗传流行病学的健康结果。 继续并增加中期和长期指导下的UCSF CTSI，公共卫生的加州大学伯克利分校学校和新的路线图K12硕士和博士的保护伞。UCSF的项目。 与UCSF全球健康研究所和NIH Fogarty国际中心培训赠款合作，扩大并获得国际培训活动的独立资金 进一步加强他自己的研究团队，促进初级教师的独立性和联合（UCSF和BSRI）招募遗传流行病学家，以帮助实验室扩展到这一新的研究领域。