MR Physics Simulation Package for Pulse, Sequence, and Hardware Design

用于脉冲、序列和硬件设计的 MR 物理仿真包

• 批准号: 7251621
• 负责人: Christopher M Collins
• 金额: $ 26.35万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7251621
• 关键词: Algorithms; Anatomy; Biological Models; Biomedical Research; Caring; Code; Communities; Complex; Computer software; Computers; Data; Detection; Development; Diagnostic; Drug or chemical Tissue Distribution; Electromagnetic Fields; Engineering; Equation; Evaluation; Frequencies; Goals; Head; Human; Human Resources; Human body; Image; Instruction; Invasive; Journals; Laws; Libraries; Link; Living Costs; Magnetic Resonance Imaging; Medical; Medicine; Methods; Mind; Modification; Morphologic artifacts; Noise; Operative Surgical Procedures; Output; Peer Review; Physics; Physiologic pulse; Physiological; Process; Property; Publishing; Pulse taking; Rate; Reading; Regulation; Relaxation; Research; Research Personnel; Safety; Sampling; Signal Transduction; Simulate; Solutions; Speed; Staging; System; Techniques; Testing; Text; Time; Tissues; Today; Training and Education; Validation; Variant; Writing; absorption; cost; design; desire; graphical user interface; human tissue; image processing; image reconstruction; improved; magnetic field; novel; open source; programs; prototype; reconstruction; research and development; research study; simulation; software development; technology/technique; theories; tool

DESCRIPTION (provided by applicant): Project Summary: We propose to develop software to accurately simulate the MRI process, from spin excitation through image reconstruction, with rigorous implementation of the physical laws of MRI and accurate 3D representations of human anatomies, field distributions, and tissue spin magnetization and relaxation properties. The output will be realistic images, accurately representing signal, contrast, and noise distributions, static and RF field-related artifacts (among many other things) for the chosen sample, sequence, and fields. This will facilitate an intermediate, low-cost stage of evaluation, revision, and optimization before implementation of novel hardware, pulses, or sequences on an MRI system. For use with the software, we will provide a library of realistic static, gradient, and RF magnetic field distributions at several field strengths from 1.0 to 9.4 tesla, human anatomies, basic pulse sequences, and reconstruction methods. The user will also be able to input specially-designed subject anatomies, different tissue spin magnetization/relaxation properties, novel field distributions at any field strength, exotic pulse sequences, and/or new reconstruction methods. The software will also calculate the head-average and maximum local Specific energy Absorption Rates (SAR) for the desired pulse sequence for comparison to safety regulations. All will be freely available and open-source so researchers can make modifications for their specific needs. Relevance: Advances in MRI have made it an invaluable tool in medicine and research in recent years, saving both lives and cost of care with accurate non-invasive diagnostic, anatomic, and physiologic information. Continual effort is devoted to improving MRI by using higher static field strengths, and thus higher RF field frequencies, but distortions of the applied fields by the human body present significant obstacles to the advancement of MRI. With the tools we will provide it will be possible to perform critical research, development, and safety evaluation of pulses, sequences, and hardware at any field strength using computers to reduce the need for magnet time and the cost of implementing untested prototypes on actual MRI systems. It will also make an excellent tool for MR education and training. This should greatly reduce the cost and increase the speed and accessibility of advancement of MRI and allow for valuable MRI system time to be dedicated more to important medical and scientific studies and less to evaluation of technical developments.

描述（由申请人提供）： 项目摘要：我们建议开发软件来准确模拟 MRI 过程，从自旋激励到图像重建，严格执行 MRI 物理定律，并准确地 3D 表示人体解剖结构、场分布以及组织自旋磁化和弛豫特性。输出将是真实的图像，准确地表示所选样本、序列和场的信号、对比度和噪声分布、静态和射频场相关伪影（以及许多其他内容）。这将有助于在 MRI 系统上实施新型硬件、脉冲或序列之前进行中间、低成本的评估、修订和优化阶段。为了与该软件一起使用，我们将提供一个包含 1.0 至 9.4 特斯拉多种场强的真实静态、梯度和射频磁场分布库、人体解剖学、基本脉冲序列和重建方法。用户还能够输入专门设计的受试者解剖结构、不同的组织自旋磁化/弛豫特性、任何场强下的新颖场分布、奇异脉冲序列和/或新的重建方法。该软件还将计算所需脉冲序列的头部平均和最大局部比能吸收率 (SAR)，以便与安全法规进行比较。所有这些都将免费提供并开源，以便研究人员可以根据自己的特定需求进行修改。相关性：近年来，MRI 的进步使其成为医学和研究领域的宝贵工具，通过准确的非侵入性诊断、解剖和生理信息挽救生命并降低护理成本。人们不断致力于通过使用更高的静态场强度和更高的射频场频率来改进 MRI，但人体施加的场的扭曲对 MRI 的进步构成了重大障碍。借助我们将提供的工具，可以使用计算机在任何场强下对脉冲、序列和硬件进行关键研究、开发和安全评估，以减少对磁体时间的需求以及在实际 MRI 系统上实施未经测试的原型的成本。它还将成为 MR 教育和培训的绝佳工具。这将大大降低成本并提高 MRI 进步的速度和可及性，并允许将宝贵的 MRI 系统时间更多地用于重要的医学和科学研究，而不是用于技术发展的评估。