3D Facial Imaging in FASD (U01)

FASD 中的 3D 面部成像 (U01)

• 批准号: 7342564
• 负责人: TATIANA M. FOROUD
• 金额: $ 35.94万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7342564
• 关键词: Address; Adolescent; Affect; Africa; Age; Alcohol consumption; Alcohol-Related Neurodevelopmental Disorder; Alcohols; Algorithms; Animal Model; Animals; Basic Science; Behavioral; Binding Sites; Biology; Brain; Brain imaging; Cells; Characteristics; Child; Choline; Classification; Clinical; Clinical Research; Collaborations; Computers; Data; Data Analyses; Development; Diagnosis; Diagnostic; Dietary Intervention; Drug Design; Dysmorphology; Early Diagnosis; Early Intervention; Elements; Emotional; Ensure; Ethanol; Ethnic group; Face; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Frequencies; Future; Genetic Polymorphism; Goals; Human; Image; Image Analysis; Impairment; Individual; Infant; Infant Development; Informal Social Control; Informatics; Intervention; Knowledge; Language; Language Development; Lasers; Learning; Life; Longevity; Los Angeles; Machine Learning; Magnetic Resonance Imaging; Measures; Medical; Methods; Mission; Modeling; Moscow; Mothers; Mus; Names; Neonatal; Neural Cell Adhesion Molecule L1; Neurobiology; New Mexico; Outcome; Pattern; Pattern Recognition; Performance; Phase; Phenotype; Pilot Projects; Play; Population; Positioning Attribute; Pregnancy; Principal Investigator; Procedures; Range; Rattus; Recording of previous events; Request for Applications; Research; Research Personnel; Research Project Grants; Resolution; Role; Sampling; Schools; Scientist; Sensitivity and Specificity; Series; Sheep; Signal Pathway; Signal Transduction; Site; Specificity; Staging; Structure; Sum; Supplementation; Techniques; Technology; Testing; Therapeutic; Three-Dimensional Image; Three-Dimensional Imaging; Time; Toddler; Translating; Ukraine; Ultrasonography; Variant; Woman; Work; alcohol exposure; alcohol sensitivity; analog; base; brain behavior; brain morphology; clinical Diagnosis; clinically relevant; cognitive control; craniofacial; critical developmental period; data integration; disorder control; drinking; follow-up; improved; in utero; infancy; literacy; member; mouse model; multidisciplinary; neurobehavioral; northern plains; novel; prenatal; prenatal exposure; programs; prospective; reconstruction; social; success; three dimensional structure

DESCRIPTION (provided by applicant): During the past three years, members of the Facial Imaging Core have worked with the Consortium to apply novel methods to more effectively diagnose FAS using 3D images from an ethnically diverse sample. These data and their subsequent analyses were used to identify features which consistently and reliably distinguished individuals with a clinical diagnosis of FAS from controls. Based on the initial success of the 'Facial Imaging Core', we now propose an expanded series of aims to be part of a clinical project named '3D Facial Imaging in FASD'. Subsequent work proposed in this study will build on the lessons learned in this first phase of research and utilize improved technology and sampling procedures to extend the diagnostic utility of these novel techniques to a wider range of individuals with prenatal alcohol exposure or FASD. In collaboration with several clinical projects, we will collect a longitudinal, multi-ethnic sample of individuals prenatally exposed to alcohol. This sample will allow us to reliably separate the effects of ethnic variation and developmental age from those due to alcohol exposure. We will also continue to work with the basic science projects to ensure that results in the different species (human, mouse, sheep) are used to inform analyses in each project. The overarching goals of this project are to: Goal 1: improve understanding of the dysmorphic features in FAS and FASD; Goal 2: enhance the capability for definitive diagnosis of FAS and the broader spectrum of FASD at different stages of the lifespan; and Goal 3: establish whether there is a relationship between FAS and FASD dysmorphic features and the specific underlying impairments in brain function.

描述（由申请人提供）：在过去的三年中，面部成像核心的成员与该联盟合作，应用新的方法，使用来自不同种族样本的3D图像更有效地诊断FAS。这些数据及其随后的分析用于确定一致且可靠地将FAS临床诊断个体与对照个体区分开的特征。基于“面部成像核心”的初步成功，我们现在提出了一系列扩展的目标，成为名为“FASD中的3D面部成像”的临床项目的一部分。本研究中提出的后续工作将建立在第一阶段研究中吸取的经验教训的基础上，并利用改进的技术和采样程序，将这些新技术的诊断实用性扩展到更广泛的产前酒精暴露或FASD个体。与几个临床项目合作，我们将收集产前暴露于酒精的个体的纵向，多种族样本。这个样本将使我们能够可靠地将种族差异和发育年龄的影响与酒精暴露的影响分开。我们还将继续与基础科学项目合作，以确保不同物种（人类，小鼠，绵羊）的结果用于每个项目的分析。该项目的总体目标是：目标1：提高对FAS和FASD畸形特征的理解;目标2：提高在生命的不同阶段对FAS和更广泛的FASD进行明确诊断的能力;目标3：确定FAS和FASD畸形特征与脑功能的特定潜在损伤之间是否存在关系。