Conferences on Emerging Statistical Issues in Biomedical Research

描述(申请人提供)：随着生物技术特别是基因组学的快速发展和生物医学研究的日益复杂，定量方法在设计和分析癌症、心血管疾病和其他慢性疾病的基础科学研究、观察性研究和临床试验中变得越来越重要。现代生物医学研究已经变得更加跨学科，提出了大量新出现的统计和计算问题，迫切需要开发创新的量化方法，特别是在观察性研究、高维度基因组和蛋白质组研究、疾病检测和预防、环境流行病学、营养和体力活动流行病学、长期随机和观察性研究的设计和分析以及因果推理的作用方面。我们建议每年召开一次生物医学研究中新出现的统计问题会议，每个会议都集中在最近生物医学研究感兴趣的一个新兴量化研究领域，并且每个会议的特定重点随着时间的推移而演变。会议的目的是为癌症、心血管疾病和其他慢性病领域的生物统计学家、量化研究人员和科学家提供一个及时的跨学科平台，以批评现有的量化方法，深入讨论新出现的统计问题，确定优先事项并传播结果。 会议将由两个世界领先的生物统计部门主办。题为“生物医学研究中新出现的统计问题：观察性研究”的第一次会议将与联合统计会议一起于2006年在西雅图华盛顿大学校园举行，以宣传该系列会议。它将由华盛顿大学生物统计学系和弗雷德·哈钦森癌症研究中心共同发起。第二至第五次会议将于2007年至2010年在波士顿哈佛大学公共卫生学院举行，每次会议都侧重于一个新兴的量化研究领域，例如，第二次会议“生物医学研究中新出现的统计问题：生物信息学和基因组流行病学”。它将由HSPH的生物统计部门和Dana-Farber癌症研究所的生物统计和计算生物学部门共同主办。将认真努力让妇女和少数群体参与会议活动。

DESCRIPTION (provided by applicant): With the rapid advance of biotechnology especially in genomics and growing complexity of biomedical research, quantitative methods have become increasingly important in design and analysis of basic sciences studies, observational studies and clinical trials in cancer, cardiovascular and other chronic diseases. Modern biomedical research, which has become more interdisciplinary in nature, presents a significant number of emerging statistical and computational issues and places an urgent call for the developments of innovative quantitative methods, especially in observational studies, high-dimensional genomic and proteomic studies, disease detection and prevention, environmental epidemiology, nutritional and physical activity epidemiology, and designs and analysis of long-term randomized and observational studies and the role of causal inference. We propose an annual Conference on Emerging Statistical Issues in Biomedical Research, where each conference focuses on an emerging quantitative research area of most recent biomedical research interest and the particular focus of each conference evolves over time. The purpose of the Conference is to provide a timely interdisciplinary platform for biostatisticians, quantitative researchers and scientists in cancer, cardiovascular and other chronic diseases to critique existing quantitative methods, discuss in-depth emerging statistical issues, identify priorities and disseminate results. The Conference will be hosted by two world-leading biostatistics departments. The first conference entitled, "Emerging Statistical Issues in Biomedical Research: Observational Studies," will be launched in 2006 at the University of Washington campus in Seattle, in conjunction with the Joint Statistical Meeting, in order to publicize the Conference Series. It would be co-sponsored by the Departments of Biostatistics of the University of Washington and the Fred Hutchinson Cancer Research Center. The second to the fifth conferences will be held at the Harvard School of Public Health in Boston between 2007 and 2010, with each focusing on an emerging quantitative research area, e.g., the second conference on "Emerging Statistical Issues in Biomedical Research: Bioinformatics and Genomic Epidemiology." It would be cosponsored by the Department of Biostatistics of the HSPH and the Department of Biostatics and Computational Biology of the Dana-Farber Cancer Institute. Serious efforts would be made to engage women and minorities in Conference activities.