28th International Herpesvirus Workshop,

第28届国际疱疹病毒研讨会，

• 批准号: 7255747
• 负责人: JAY A NELSON
• 金额: $ 2.19万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7255747
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Atherosclerosis; B-Lymphocytes; Biological Models; Blindness; Bos taurus; Burkitt Lymphoma; Cattle; Cells; Chickenpox; Clinical Research; Congenital Abnormality; Cytomegalovirus; DNA biosynthesis; Development; Disease; Domestic Fowls; Economics; Educational workshop; Elderly; Encephalitis; Equus caballus; Eye; Family suidae; Fertilization; Funding; Gene Expression Regulation; Gene Transduction Agent; Genetic Engineering; Genital system; Herpes zoster disease; Herpesviridae; Herpesviridae Infections; Herpesvirus 1; Human; Human Herpesvirus 2; Human Herpesvirus 4; Human Herpesvirus 8; Immune; Immune response; Infectious Mononucleosis; International; Kaposi Sarcoma; Lesion; Life; Malignant Neoplasms; Medical; Membrane Proteins; Meningitis; Mental Retardation; Molecular Biology; Morbidity - disease rate; Nasopharynx Carcinoma; Neoplasms; Organ Transplantation; Pathogenesis; Patients; Persons; Population; Postherpetic neuralgia; Request for Proposals; Research; Research Personnel; Rest; Simplexvirus; Skin; Structure; Students; Suid Herpesvirus 1; Training; Transcriptional Regulation; Transplant Recipients; Ulcer; Vaccination; Virus; Wisconsin; base; deafness; design; gene therapy; interdisciplinary approach; mortality; novel vaccines; pathogen; transmission process

DESCRIPTION (provided by applicant): This proposal requests funds to enable young investigators to attend the 28th International Herpesvirus Workshop at the Monona Terrace Convention Center, Madison, Wisconsin, July 26-August 1, 2003. The International Herpesvirus Workshop is the premier scientific meeting for herpesvirus researchers, and the only meeting with an interdisciplinary focus on all the major subfamilies of herpesviruses and all aspects of research from molecular biology to clinical studies. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpesviruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based world-wide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now recognized eight human herpesviruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. More recently, CMV and HSV have been implicated as pathogenic contributors in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt's lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi' sarcoma in AIDS patients and other immunosupressed persons and in other groups. All of the herpesviruses persist for life and therefore pose significant problems in the treatment of immunologically compromised persons. Diseases caused by reactivation of most human herpesviruses are a significant cause of morbidity and mortality in various immune patient populations. Shingles and post-herpetic neuralgia are problems in the elderly. Animal herpesviruses are of significant economic importance to poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpesviruses) and horses (several equine herpesviruses). In addition, these animal herpesviruses serve as important model systems for studying herpesvirus pathogenesis. Finally, recombinant DNA technology permits the design of novel vaccines for controlling the spread of animal herpesvirus infection and the design of herpesvirus vectors for gene therapy. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy.

描述（由申请人提供）：本提案要求提供资金，以使年轻的研究人员能够参加2003年7月26日至8月1日在威斯康星州麦迪逊的莫诺纳露台会议中心举行的第28届国际疱疹病毒研讨会。 国际疱疹病毒研讨会是疱疹病毒研究人员的首要科学会议，也是唯一一次跨学科关注疱疹病毒所有主要亚科以及从分子生物学到临床研究的所有方面的会议。 讲习班的优势在于通过比较不同的疱疹病毒、解决关键问题的不同方法以及该领域主要研究人员的支持和参与而产生的相互交流，最重要的是包括有前途的年轻研究人员和受训学生。 此外，该论坛是真正的国际性论坛，世界各地的与会者基础广泛。 这次会议的医学重要性从现在公认的八种人类疱疹病毒引起的各种疾病中清楚地表明。 这些疾病包括皮肤和眼睛溃疡（HSV-1）、生殖器病变（HSV-2）、脑膜炎和脑炎（HSV-1和HSV-2）、传染性单核细胞增多症（EBV）、水痘和带状疱疹（VZV）。 巨细胞病毒是先天性传播导致的包括智力迟钝、失明和耳聋在内的出生缺陷的主要原因，但也是艾滋病患者和器官移植受者中的重要机会病原体。 最近，CMV和HSV被认为是动脉粥样硬化发展中的致病因素。 癌症也与疱疹病毒感染有关。 EB病毒与伯基特淋巴瘤、其他B细胞肿瘤和鼻咽癌有关。 最近发现的人类疱疹病毒（HHV-8或KSHV）与艾滋病患者和其他免疫抑制者及其他人群的卡波西肉瘤有关。 所有的疱疹病毒持续终生，因此在治疗免疫功能低下的人时会造成严重的问题。 由大多数人疱疹病毒的再活化引起的疾病是各种免疫患者群体中发病率和死亡率的重要原因。 带状疱疹和带状疱疹后神经痛是老年人的问题。 动物疱疹病毒对家禽（马立克氏病等）、猪（伪狂犬病病毒）、牛（几种牛疱疹病毒）和马（几种马疱疹病毒）具有重要的经济意义。 此外，这些动物疱疹病毒还是研究疱疹病毒发病机制的重要模型系统。 最后，重组DNA技术允许设计用于控制动物疱疹病毒感染传播的新型疫苗和用于基因治疗的疱疹病毒载体。 研讨会将采取跨学科的方法来研究以下主题：病毒结构，病毒进入和细胞-细胞传播的机制，膜蛋白，发病机制和潜伏期，DNA复制，疫苗接种和免疫反应，转录控制，基因表达调控，化疗靶点和病毒基因治疗。