TRAINING GRANT IN NEURODEVELOPMENTAL DISABILITIES

描述（由申请人提供）：据估计，发育障碍影响了美国10%的家庭。迫切需要愿意并能够运用现代研究方法来阐明这些疾病的发病机制和病理生理的研究人员，以便发现新的和更有效的治疗干预措施。我们在费城儿童医院（CHOP）和宾夕法尼亚大学（U of P）的跨学科机构神经发育障碍博士后培训计划的目标是培养医学博士和博士博士后，专注于导致智力迟钝和发育障碍的遗传和获得性疾病的研究。19位导师将参加该项目的首次竞争性更新；13个主要设在CHOP， 6个主要设在university of P.所有这些都大量参与生物医学研究生教育，并通过相互研究项目和赠款密切联系在一起。除了有指导的研究训练外，我们的课程还强调医学博士和博士的临床实习要求，通过明尼苏达大学研究生课程的正式课程，以及生物伦理学，生物统计学和科学写作和演示技能的培训。在我们项目的前4年，我们接受了8名学员，其中2名是医学博士，5名是博士，1名是医学博士/博士。到目前为止，完成我们课程的5人中，2人获得了初级教师职位，2人在返回学术生涯之前进入临床培训项目（1人在神经病学，1人在神经外科），1人接受了生物技术公司的职位。另外两名学员将在明年完成我们的项目；每个人都被邀请并接受了医学院助理教授的职位（一个在神经病学和儿科，普林斯顿大学，另一个在精神病学，加州大学洛杉矶分校）。我校前5年每年获批4名博士后，今后5年申请同等资助。

DESCRIPTION (provided by applicant): It has been estimated that developmental disabilities affect 10% of all families in the USA. Researchers are urgently needed who are willing and able to apply modern research methods to elucidating the pathogenesis and pathophysiology of these disorders, so that new and more effective therapeutic interventions can be identified. The aim of our interdisciplinary Institutional Post-doctoral Training Program in Neurodevelopmental Disabilities, based at The Children's Hospital of Philadelphia (CHOP) and The University of Pennsylvania (U of P), is to train MD and PhD post-doctoral fellows in research focused on genetic and acquired disorders that cause mental retardation and developmental disability. Nineteen Mentors will participate in this first competitive renewal of this program; 13 are based primarily at CHOP, and 6 primarily at the U of P. All are heavily involved in biomedical graduate education and are closely interlinked by mutual research projects and grants. In addition to mentored research training, our curriculum emphasizes a clinical practicum requirement for both MDs and PhDs, formal course work through the U of P Graduate Studies Program, and training in bioethics, biostatistics, and skills in scientific writing and presentation. During the first 4 years of our program, we accepted 8 Trainees, of whom 2 were MDs, 5 PhDs, and 1 and MD/PhD. Of the 5 who have thus far completed our program, 2 have obtained junior faculty positions, 2 have entered clinical training programs (1 in neurology, 1 in neurosurgery) prior to returning to an academic career, and 1 accepted a position in a biotechnology firm. Two additional Trainees will complete our program during the coming year; each has been offered and accepted a medical school assistant professorship (1 in Neurology and Pediatrics, U of P, the other in Psychiatry, UCLA). We were approved for 4 post-doctoral fellows/year during our first 5 years, and request the same level of funding for the next 5 years.