Gene Polymorphisms, Inflammation and Outcome from Trauma

基因多态性、炎症和创伤后果

• 批准号: 7214856
• 负责人: GRANT E O'KEEFE
• 金额: $ 29.47万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7214856
• 关键词: Abbreviated Injury Scale; Acute; Acute Appendicitis; Affect; Agonist; Alleles; Appendicitis; Boxing; Case Fatality Rates; Cell Separation; Cessation of life; Clinical; Clinical Trials; Constitution; DNA Library; Databases; Descriptor; Disease; Failure; Fluorescent Antibody Technique; Focal Infection; Gangrene; Gelshift Analysis; Genes; Genetic; Genetic Polymorphism; Genotype; Grant; Haplotypes; Hemorrhagic Shock; Hour; Human; IV Fluid; In Vitro; Individual; Infection; Inflammation; Inflammatory Response; Inherited; Injury; Injury Severity Score; Investigation; Knowledge; Leukocytes; Link; Measures; Microscopic; Modeling; Necrosis; Numbers; Organ; Organ failure; Outcome; Patients; Perforation; Perfusion; Research Personnel; Risk; Role; Score; Sepsis; Sepsis Syndrome; Septic Shock; Series; Severities; Single Nucleotide Polymorphism; Single base substitution; Trauma; United States; genetic risk factor; in vitro Model; in vivo; response

DESCRIPTION (provided by applicant): Our overall aim is to identify and characterize genetic differences that are important to the human response to infection and inflammation. First, we will use in vivo and in vitro models of inflammation to determine the functional impact of single nucleotide polymorphisms (SNPs) in inflammation-related genes. Second, we propose to identify SNPs that will help characterize an individual patient's risk for severe infection and death after injury. This information will allow clinicians and researchers to more rationally investigate and use specific therapies aimed at reducing the devastating consequences of severe injury and infection.

描述(由申请人提供)：我们的总体目标是识别和表征对人类对感染和炎症的反应重要的基因差异。首先，我们将使用体内和体外炎症模型来确定炎症相关基因的单核苷酸多态(SNPs)对功能的影响。其次，我们建议确定SNPs，这些SNPs将有助于表征单个患者在受伤后严重感染和死亡的风险。这些信息将使临床医生和研究人员能够更理性地研究和使用旨在减少严重伤害和感染的破坏性后果的特定疗法。

项目成果

Traumatic injury, early gene expression, and gram-negative bacteremia.

• DOI: 10.1097/ccm.0000000000000218
• 发表时间: 2014-06
• 期刊: Critical care medicine
• 影响因子: 8.8
• 作者: Thompson CM;Park CH;Maier RV;O'Keefe GE
• 通讯作者: O'Keefe GE

HLA-A Locus is Associated With Sepsis and Septic Shock After Traumatic Injury.

• DOI: 10.1097/sla.0000000000003932
• 发表时间: 2022-01-01
• 期刊: Annals of surgery
• 影响因子: 9

A Potential Mechanism for Immune Suppression by Beta-Adrenergic Receptor Stimulation following Traumatic Injury.

• DOI: 10.1159/000486972
• 发表时间: 2018
• 期刊: Journal of innate immunity
• 影响因子: 5.3
• 作者: Shubin NJ;Pham TN;Staudenmayer KL;Parent BA;Qiu Q;O'Keefe GE
• 通讯作者: O'Keefe GE

Safety of minimizing preoperative starvation in critically ill and intubated trauma patients.

• DOI: 10.1097/ta.0000000000001011
• 发表时间: 2016-06
• 期刊: The journal of trauma and acute care surgery
• 作者: Parent BA;Mandell SP;Maier RV;Minei J;Sperry J;Moore EE;O'Keefe GE
• 通讯作者: O'Keefe GE

Toll-like receptor 1 polymorphisms and associated outcomes in sepsis after traumatic injury: a candidate gene association study.

• DOI: 10.1097/sla.0b013e31828538e8
• 发表时间: 2014-01
• 期刊: Annals of surgery
• 影响因子: 9
• 作者: Thompson CM;Holden TD;Rona G;Laxmanan B;Black RA;OʼKeefe GE;Wurfel MM
• 通讯作者: Wurfel MM