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Gene Polymorphisms, Inflammation and Outcome from Trauma

Gene Polymorphisms, Inflammation and Outcome from Trauma
基因多态性、炎症和创伤后果
批准号：
6729933
负责人：
GRANT E O'KEEFE
金额：
$31.08万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
项目状态：
已结题
起止时间：
2003-04-01 至 2008-03-31
来源：
https://reporter.nih.gov/project-details/6729933
关键词：
bacterial cytopathogenic effectbacterial diseaseclinical chemistryclinical researchcolonic diverticulosisenzyme linked immunosorbent assayflow cytometrygene expressiongenetic susceptibilitygenotypehuman genetic material taghuman mortalityhuman subjectinflammationinterleukin 6leukocyte activation /transformationlipopolysaccharidesmedical complicationnucleic acid sequenceoutcomes researchpolymerase chain reactionseptic shocksepticemiasingle nucleotide polymorphismtissue resource /registrytrauma

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DESCRIPTION (provided by applicant): Our overall aim is to identify and characterize genetic differences that are important to the human response to infection and inflammation. First, we will use in vivo and in vitro models of inflammation to determine the functional impact of single nucleotide polymorphisms (SNPs) in inflammation-related genes. Second, we propose to identify SNPs that will help characterize an individual patient's risk for severe infection and death after injury. This information will allow clinicians and researchers to more rationally investigate and use specific therapies aimed at reducing the devastating consequences of severe injury and infection.
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