Gene Polymorphisms, Inflammation and Outcome from Trauma

基因多态性、炎症和创伤后果

• 批准号: 6560851
• 负责人: GRANT E O'KEEFE
• 金额: $ 31.08万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6560851
• 关键词: bacterial cytopathogenic effect; bacterial disease; clinical chemistry; clinical research; colonic diverticulosis; enzyme linked immunosorbent assay; flow cytometry; gene expression; genetic susceptibility; genotype; human genetic material tag; human mortality; human subject; inflammation; interleukin 6; leukocyte activation /transformation; lipopolysaccharides; medical complication; nucleic acid sequence; outcomes research; polymerase chain reaction; septic shock; septicemia; single nucleotide polymorphism; tissue resource /registry; trauma

DESCRIPTION (provided by applicant): Our overall aim is to identify and characterize genetic differences that are important to the human response to infection and inflammation. First, we will use in vivo and in vitro models of inflammation to determine the functional impact of single nucleotide polymorphisms (SNPs) in inflammation-related genes. Second, we propose to identify SNPs that will help characterize an individual patient's risk for severe infection and death after injury. This information will allow clinicians and researchers to more rationally investigate and use specific therapies aimed at reducing the devastating consequences of severe injury and infection.

描述（由申请人提供）：我们的总体目标是鉴定和表征对人类对感染和炎症反应重要的遗传差异。首先，我们将使用体内和体外炎症模型来确定炎症相关基因中单核苷酸多态性（SNP）的功能影响。其次，我们建议确定SNPs，这将有助于表征个体患者的严重感染和受伤后死亡的风险。这些信息将使临床医生和研究人员能够更合理地调查和使用旨在减少严重损伤和感染的破坏性后果的特定疗法。