Core C: Analytical Core

核心 C:分析核心

基本信息

  • 批准号:
    7158291
  • 负责人:
  • 金额:
    $ 9.47万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-07-01 至 2011-06-30
  • 项目状态:
    已结题

项目摘要

The overall objective of the Analytical Chemistry Core is to provide analytical support for the human monitoring, animal model, and cell biology projects in the program project. We will apply techniques to the research projects as appropriate, and will advance the technology upon which the analytical methodology is based. This core will conduct new analyses on serum samples from the CHARGE study, collected during the previous funding period, new samples from the CHARGEBACK and MARBLES study (see Projects 1 and 2). We will evaluate new methods to apply to the prospective study of future siblings and to test specific hypotheses. A major goal will be to generate data sets of xenobiotic exposure and metabolomic biomarkers to regress against transcriptome and proteome data by determining both xenobiotic exposure and levels of endogenous metabolites on selected . We will evaluate metabolite profiles in animal models emphasizing immune dysfunction. In human samples, we will pay particular attention to metabolites indicative of inflammatory status and plasma leptin levels recently found as a biomarker to distinguish between early onset and clinical regression autism. We also will monitor the metabolite profiles in T cells, B cells and natural killer (NK) cells of normal and autistic children with and without exposure to xenobiotics. Of equal importance we will provide a walk up instrument and consultation service in analytical chemistry for the entire core the Specific Aims are: 1. Establish the metabolic pathways responsible for variations in lipid composition between autistic children and their siblings and between normal and immunologically challenged animal models of autism. 2. Use global metabolomic procedures to search for biomarkers of autism. 3. Provide analytical data on pesticide and other xenobiotic levels in cell and in vivo model systems and in serum samples from the CHARGE, CHARGE-BACK, MARBLES, and other successor studies. 4. Develop new analytical methods for xenobiotics of interest to scientists in the program project.
分析化学核心的总体目标是提供分析支持

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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BRUCE D HAMMOCK其他文献

BRUCE D HAMMOCK的其他文献

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{{ truncateString('BRUCE D HAMMOCK', 18)}}的其他基金

Soluble epoxide hydrolase and epoxide fatty acid involvement in corneal injury after ammonia exposure: Mechanisms of injury and potential therapeutics using sEH inhibitors and biostable EpFA mimics.
可溶性环氧化物水解酶和环氧化物脂肪酸参与氨暴露后角膜损伤:损伤机制和使用 sEH 抑制剂和生物稳定 EpFA 模拟物的潜在治疗方法。
  • 批准号:
    10708436
  • 财政年份:
    2023
  • 资助金额:
    $ 9.47万
  • 项目类别:
Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases
生物活性脂质作为环境暴露对慢性疾病有害影响的效应物和指标
  • 批准号:
    10400036
  • 财政年份:
    2019
  • 资助金额:
    $ 9.47万
  • 项目类别:
Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases
生物活性脂质作为环境暴露对慢性疾病有害影响的效应物和指标
  • 批准号:
    10615675
  • 财政年份:
    2019
  • 资助金额:
    $ 9.47万
  • 项目类别:
Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases
生物活性脂质作为环境暴露对慢性疾病有害影响的效应物和指标
  • 批准号:
    10153794
  • 财政年份:
    2019
  • 资助金额:
    $ 9.47万
  • 项目类别:
Clinical Paths for Soluble Epoxide Hydrolase Inhibitors at Experimental Biology 2018
2018 年实验生物学中可溶性环氧化物水解酶抑制剂的临床路径
  • 批准号:
    9544621
  • 财政年份:
    2018
  • 资助金额:
    $ 9.47万
  • 项目类别:
Role of Epoxygenated Fatty Acids in Modulating Pain
环氧化脂肪酸在调节疼痛中的作用
  • 批准号:
    8446055
  • 财政年份:
    2013
  • 资助金额:
    $ 9.47万
  • 项目类别:
Role of Epoxygenated Fatty Acids in Modulating Pain
环氧化脂肪酸在调节疼痛中的作用
  • 批准号:
    8619587
  • 财政年份:
    2013
  • 资助金额:
    $ 9.47万
  • 项目类别:
Analytical Chemistry
分析化学
  • 批准号:
    10204120
  • 财政年份:
    2012
  • 资助金额:
    $ 9.47万
  • 项目类别:
METHODS MONITOR TOXIC SUBSTAN AND/OR INDICATORS OF PRESENCE IN HUMANS&OTHER SPE
监测人类体内有毒物质和/或存在指标的方法
  • 批准号:
    8362756
  • 财政年份:
    2011
  • 资助金额:
    $ 9.47万
  • 项目类别:
EFFECT OF PHTHALATES ON PRIMATE PREGNANCY
邻苯二甲酸盐对灵长类动物怀孕的影响
  • 批准号:
    8357275
  • 财政年份:
    2011
  • 资助金额:
    $ 9.47万
  • 项目类别:

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动物组织形态发生的分子机制
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