American Heart Association Tobacco Center for Regulatory Science (A-TRAC) 2.0

美国心脏协会烟草监管科学中心 (A-TRAC) 2.0

• 批准号: 10017285
• 负责人: Aruni Bhatnagar
• 金额: $ 369.21万
• 依托单位: AMERICAN HEART ASSOCIATION
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10017285
• 关键词: American Heart Association; Animal Model; Area; Belief; Biological Markers; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Communication; Communities; Coordination and Collaboration; Country; Data; Development; Devices; Emerging Tobacco Products; Environment; Evaluation; Family; Fostering; Funding; General Population; Goals; Grant; Health; Human; Institution; Interdisciplinary Study; Knowledge; Leadership; Marketing; Measurement; Methods; Mission; Perception; Quality Control; Regulation; Relative Risks; Research; Research Activity; Research Personnel; Research Support; Research Training; Resources; Role; Science; Scientist; Smoking Prevention; Stroke; Testing; Tobacco; Tobacco use; Toxic effect; United States; United States Food and Drug Administration; United States National Institutes of Health; Vulnerable Populations; Work; authority; base; cardiovascular disorder risk; cardiovascular health; cardiovascular injury; cardiovascular risk factor; career; career development; cigarette smoking; cohort; combustible cigarette; disorder risk; experience; improved; in vitro Assay; innovation; next generation; programs; reduce tobacco use; repository; response; synergism; tobacco advertising; tobacco products; tobacco regulatory science

PROJECT SUMMARY The overall goal of the American Heart Association (AHA) Tobacco Regulation Center (ATRAC) is to provide scientific data relevant to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). The integrative theme of the Center is to evaluate and communicate the cardiovascular effects of tobacco products, within the scientific domains of Health Effects, Toxicity and Communications. Research within the Center will contribute to the scientific base of tobacco regulatory science by evaluating the cardiovascular effects of tobacco products and their constituents. The Center will support a multi-disciplinary research program to assess the toxicity of tobacco products and their constituents in in vitro assays and animal models (Project 1); evaluate short- and long-term cardiovascular health effects of tobacco products (Project 2) and assess the cardiovascular disease risk associated with the use of non-cigarette tobacco products in multiple large NIH-supported cardiovascular cohorts (Project 3). To communicate the knowledge generated within the Center and other Tobacco Centers of Regulatory Science (TCORS), the Center will develop and test approaches for effective communication of the cardiovascular consequences of tobacco product use (Project 4). To facilitate uniformity, and quality control, all measurements will be conducted in a centralized Bioanalytical and Biomarker Core. The research activities within the Center will be coordinated by an Administrative Core, while the Career Enhancement Core will oversee the career development of new and early stage investigators. The Administrative Core will maintain close communication with federal partners and will oversee the development, funding and progress of Rapid Response Projects. Research supported by the Center will develop new understanding of the cardiovascular effects of current, new and emerging tobacco products; aid in the development of messages for communicating the cardiovascular risk associated with the use of tobacco products; and build and deploy capacity and expertise to respond to new developments. Collectively, Center research will broaden the scientific base of tobacco regulatory science to inform FDA's regulation of tobacco manufacturing, distribution and marketing.

项目摘要 美国心脏协会（AHA）烟草监管中心（ATRAC）的总体目标是提供 与食品药品监督管理局（FDA）烟草中心有关的科学数据 产品（CTP）。该中心的综合主题是评估和传达心血管效应 在健康影响，毒性和传播的科学领域内的烟草产品。研究 中心内将通过评估烟草监管科学的科学基础 烟草产品及其成分的心血管效应。该中心将支持多学科 研究计划，以评估烟草产品及其成分在体外测定和动物中的毒性 模型（项目1）;评估烟草产品的短期和长期心血管健康影响（项目2） 并评估与多种烟草产品使用非烟烟草相关的心血管疾病风险 大型NIH支持的心血管同伴（项目3）。传达在 中心和其他监管科学中心（TCOR）中心将开发和测试方法 为了有效地沟通烟草产品使用的心血管后果（项目4）。促进 均匀性和质量控制，所有测量将在集中的生物分析和生物标志物中进行 核。中心内的研究活动将由行政核心协调，而职业 增强核心将监督新的和早期研究人员的职业发展。这 行政核心将保持与联邦合作伙伴的密切沟通，并将监督开发项目， 快速响应项目的资金和进度。中心支持的研究将开发新的 了解当前，新和新兴的烟草产品的心血管影响；援助 开发与使用烟草相关的心血管风险的消息 产品;以及建立和部署能力和专业知识，以应对新的发展。集体，中心 研究将扩大烟草监管科学的科学基础，以告知FDA对烟草的监管 制造，分销和营销。