American Heart Association Tobacco Regulation and Addiction Center (A-TRAC)

美国心脏协会烟草管制和成瘾中心 (A-TRAC)

• 批准号: 8737954
• 负责人: Aruni Bhatnagar
• 金额: $ 397.25万
• 依托单位: AMERICAN HEART ASSOCIATION
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8737954
• 关键词: Address; American Heart Association; Attitude; Behavior; Biological Markers; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Communication; Core Facility; Development; Disease; Disease Outcome; Education; Ethnic Origin; Evaluation; Exposure to; Fostering; Housing; Institution; Interdisciplinary Study; Logistics; Measurement; Measures; Perception; Public Health; Regulation; Relative (related person); Research; Research Personnel; Research Priority; Research Project Grants; Research Support; Science; Tobacco; Tobacco use; Toxic effect; Training; Vulnerable Populations; addiction; authority; cardiovascular injury; career; cohort; disability; indexing; programs; response; tobacco advertising; tobacco exposure; virtual

DESCRIPTION (provided by applicant): This project is to build and develop a Tobacco Regulation and Addiction Center at the American Heart Association (AHA). This virtual Center will be a network of consortia between AHA and several leading academic institutions. It will house programs of multidisciplinary research that will inform the manufacture, distribution and marketing of tobacco products related to the regulatory authority of the FDA. Center investigators will study the cardiovascular toxicity of tobacco products and the relationship between tobacco product use and subclinical progression of cardiovascular disease to identify sensitive and robust biomarkers of cardiovascular injury related to tobacco product exposure. These studies will help to identify the relative sensitivity of specific domains of cardiovascular injury that are sensitive to tobacco exposure and facilitate the identification of harmful and potentially harmful constituents of current, new and emerging tobacco products that cause cardiovascular injury and how the impact of these constituents on cardiovascular disease outcomes could be measured. In cohorts of varying ethnicities, behavior, perceptions, and attitudes regarding tobacco products will be studied to identify which communications channels are used by vulnerable populations to obtain information about tobacco products, and which strategies are likely to be effective in discouraging initiation and continuation of tobacco use. The Center will also provide comprehensive education, state-of-the-art training in tobacco regulatory science and foster the development of independent research careers of junior investigators. Research in the Center will be supported by facilities/cores that will provide assessments and characterization of exposure to tobacco products and unified measurements of biomarkers and validated indices of cardiovascular injury. The administrative core of the Center will provide scientific, administrative and logistic oversight to all aspects of the Center and coordinate integrative team science focused on addressing the research priorities of the FDA. The Center will be well-poised to undertake strong and coordinated research projects in response to new developments and conduct collaborative research with other Centers in the Tobacco Centers of Regulatory Science. RELEVANCE: Research supported by the AHA-Tobacco Regulation and Addiction Center (A-TRAC) will aid the development and evaluation of tobacco product regulation by the FDA and thereby contribute to the protection of public health and reduction of tobacco-related disease, disability and death.

项目描述（申请人提供）：该项目是在美国心脏协会（AHA）建立和发展一个烟草管制和成瘾中心。这个虚拟中心将是AHA和几个领先的学术机构之间的联盟网络。它将容纳多学科研究计划，为与FDA监管机构有关的烟草产品的制造，分销和营销提供信息。中心研究人员将研究烟草制品的心血管毒性以及烟草制品使用与心血管疾病亚临床进展之间的关系，以确定与烟草制品暴露相关的心血管损伤的敏感和可靠的生物标志物。这些研究将有助于确定对烟草暴露敏感的心血管损伤的特定领域的相对敏感性，并有助于确定导致心血管损伤的现有、新的和新兴烟草产品的有害和潜在有害成分，以及如何衡量这些成分对心血管疾病结局的影响。在不同种族的队列中，将研究对烟草制品的行为、看法和态度，以确定弱势群体使用哪些沟通渠道来获得有关烟草制品的信息，以及哪些策略可能有效地阻止开始和继续使用烟草。该中心还将提供烟草监管科学方面的综合教育和最先进的培训，并促进初级调查人员独立研究职业的发展。该中心的研究将得到设施/核心的支持，这些设施/核心将提供烟草产品暴露的评估和表征，以及生物标志物和心血管损伤的经验证指数的统一测量。中心的行政核心将为中心的各个方面提供科学、行政和后勤监督，并协调综合团队科学，重点解决FDA的研究优先事项。该中心将做好充分准备，开展强有力的协调研究项目，以应对新的发展，并与烟草监管科学中心的其他中心开展合作研究。 相关性：由AHA烟草监管和成瘾中心（A-TRAC）支持的研究将有助于FDA制定和评估烟草产品监管，从而有助于保护公众健康，减少烟草相关疾病，残疾和死亡。