American Heart Association Tobacco Center for Regulatory Science (A-TRAC) 2.0

美国心脏协会烟草监管科学中心 (A-TRAC) 2.0

• 批准号: 10246435
• 负责人: Aruni Bhatnagar
• 金额: $ 369.21万
• 依托单位: AMERICAN HEART ASSOCIATION
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10246435
• 关键词: American Heart Association; Animal Model; Area; Belief; Biological Markers; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Communication; Communities; Coordination and Collaboration; Country; Data; Development; Devices; Emerging Tobacco Products; Environment; Evaluation; Family; Fostering; Funding; General Population; Goals; Grant; Health; Human; Institution; Interdisciplinary Study; Knowledge; Leadership; Marketing; Measurement; Methods; Mission; Perception; Quality Control; Regulation; Relative Risks; Research; Research Activity; Research Personnel; Research Support; Research Training; Resources; Role; Science; Scientist; Smoking Prevention; Stroke; Testing; Tobacco; Tobacco use; Toxic effect; United States; United States Food and Drug Administration; United States National Institutes of Health; Vulnerable Populations; Work; authority; base; cardiovascular disorder risk; cardiovascular effects; cardiovascular health; cardiovascular injury; cardiovascular risk factor; career; career development; cigarette smoking; cohort; combustible cigarette; disorder risk; experience; improved; in vitro Assay; innovation; next generation; non-cigarette tobacco product; programs; reduce tobacco use; repository; response; synergism; tobacco advertising; tobacco products; tobacco regulation; tobacco regulatory science

PROJECT SUMMARY The overall goal of the American Heart Association (AHA) Tobacco Regulation Center (ATRAC) is to provide scientific data relevant to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). The integrative theme of the Center is to evaluate and communicate the cardiovascular effects of tobacco products, within the scientific domains of Health Effects, Toxicity and Communications. Research within the Center will contribute to the scientific base of tobacco regulatory science by evaluating the cardiovascular effects of tobacco products and their constituents. The Center will support a multi-disciplinary research program to assess the toxicity of tobacco products and their constituents in in vitro assays and animal models (Project 1); evaluate short- and long-term cardiovascular health effects of tobacco products (Project 2) and assess the cardiovascular disease risk associated with the use of non-cigarette tobacco products in multiple large NIH-supported cardiovascular cohorts (Project 3). To communicate the knowledge generated within the Center and other Tobacco Centers of Regulatory Science (TCORS), the Center will develop and test approaches for effective communication of the cardiovascular consequences of tobacco product use (Project 4). To facilitate uniformity, and quality control, all measurements will be conducted in a centralized Bioanalytical and Biomarker Core. The research activities within the Center will be coordinated by an Administrative Core, while the Career Enhancement Core will oversee the career development of new and early stage investigators. The Administrative Core will maintain close communication with federal partners and will oversee the development, funding and progress of Rapid Response Projects. Research supported by the Center will develop new understanding of the cardiovascular effects of current, new and emerging tobacco products; aid in the development of messages for communicating the cardiovascular risk associated with the use of tobacco products; and build and deploy capacity and expertise to respond to new developments. Collectively, Center research will broaden the scientific base of tobacco regulatory science to inform FDA's regulation of tobacco manufacturing, distribution and marketing.

项目摘要 美国心脏协会（AHA）烟草管制中心（ATRAC）的总体目标是提供 与美国食品药品监督管理局（FDA）烟草中心监管机构相关的科学数据 产品（CTP）.中心的综合主题是评估和交流心血管效应 在健康影响、毒性和传播的科学领域内，对烟草制品进行研究。研究 中心内的专家将通过评估 烟草制品及其成分对心血管的影响。该中心将支持多学科 在体外试验和动物试验中评估烟草制品及其成分毒性的研究计划 评估烟草制品对心血管健康的短期和长期影响（项目2） 并评估与使用非卷烟烟草产品相关的心血管疾病风险， NIH支持的大型心血管队列（项目3）。为了传达在内部产生的知识， 中心和其他烟草监管科学中心（TCORS），该中心将开发和测试方法 有效宣传烟草制品使用对心血管的影响（项目4）。以促进 均匀性和质量控制，所有测量将在集中的生物分析和生物标志物 核心中心内的研究活动将由一个行政核心协调，而职业 加强核心将监督新的和早期阶段的调查员的职业发展。的 行政核心将与联邦合作伙伴保持密切沟通，并监督事态发展， 快速反应项目的资金和进展情况。该中心支持的研究将开发新的 了解当前、新的和新兴烟草产品对心血管的影响; 制定与吸烟有关的心血管风险信息 产品;建设和部署能力和专门知识，以应对新的发展。集体，中心 研究将拓宽烟草监管科学的科学基础，为FDA的烟草监管提供信息 制造、分销和营销。