American Heart Association Tobacco Regulation and Addiction Center (A-TRAC)

美国心脏协会烟草管制和成瘾中心 (A-TRAC)

• 批准号: 9328116
• 负责人: Aruni Bhatnagar
• 金额: $ 379.91万
• 依托单位: AMERICAN HEART ASSOCIATION
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9328116
• 关键词: Address; American Heart Association; Attitude; Behavior; Biological Markers; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Communication; Core Facility; Development; Disease; Disease Outcome; Education; Ethnic Origin; Evaluation; Exposure to; Fostering; Institution; Interdisciplinary Study; Logistics; Measurement; Measures; Perception; Public Health; Regulation; Research; Research Personnel; Research Priority; Research Project Grants; Research Support; Science; Tobacco; Tobacco use; Toxic effect; Training; Vulnerable Populations; addiction; authority; cardiovascular injury; career; cohort; disability; indexing; programs; response; tobacco advertising; tobacco exposure; tobacco regulatory science; virtual

DESCRIPTION (provided by applicant): This project is to build and develop a Tobacco Regulation and Addiction Center at the American Heart Association (AHA). This virtual Center will be a network of consortia between AHA and several leading academic institutions. It will house programs of multidisciplinary research that will inform the manufacture, distribution and marketing of tobacco products related to the regulatory authority of the FDA. Center investigators will study the cardiovascular toxicity of tobacco products and the relationship between tobacco product use and subclinical progression of cardiovascular disease to identify sensitive and robust biomarkers of cardiovascular injury related to tobacco product exposure. These studies will help to identify the relative sensitivity of specific domains of cardiovascular injury that are sensitive to tobacco exposure and facilitate the identification of harmful and potentially harmful constituents of current, new and emerging tobacco products that cause cardiovascular injury and how the impact of these constituents on cardiovascular disease outcomes could be measured. In cohorts of varying ethnicities, behavior, perceptions, and attitudes regarding tobacco products will be studied to identify which communications channels are used by vulnerable populations to obtain information about tobacco products, and which strategies are likely to be effective in discouraging initiation and continuation of tobacco use. The Center will also provide comprehensive education, state-of-the-art training in tobacco regulatory science and foster the development of independent research careers of junior investigators. Research in the Center will be supported by facilities/cores that will provide assessments and characterization of exposure to tobacco products and unified measurements of biomarkers and validated indices of cardiovascular injury. The administrative core of the Center will provide scientific, administrative and logistic oversight to all aspects of the Center and coordinate integrative team science focused on addressing the research priorities of the FDA. The Center will be well-poised to undertake strong and coordinated research projects in response to new developments and conduct collaborative research with other Centers in the Tobacco Centers of Regulatory Science. RELEVANCE: Research supported by the AHA-Tobacco Regulation and Addiction Center (A-TRAC) will aid the development and evaluation of tobacco product regulation by the FDA and thereby contribute to the protection of public health and reduction of tobacco-related disease, disability and death.

描述（由申请人提供）：该项目是在美国心脏协会（AHA）建立和开发烟草法规和成瘾中心。这个虚拟中心将是AHA和几个领先的学术机构之间的财团网络。它将容纳多学科研究计划，这些计划将为与FDA监管机构有关的烟草产品的制造，分销和营销提供信息。中心研究人员将研究烟草产物的心血管毒性以及烟草产品使用与心血管疾病的亚临床进展之间的关系，以鉴定与烟草产品暴露有关的心血管损伤的敏感和健壮的生物标志物。这些研究将有助于确定对烟草暴露敏感的心血管损伤特定领域的相对敏感性，并促进鉴定有害和潜在有害成分的当前，新和新兴的烟草产物，这些烟草产生心血管损伤以及这些对这些成分对心血管疾病的影响的影响可以测量。将研究有关烟草产品的各种种族，行为，看法和态度，以确定弱势群体使用哪些通信渠道来获取有关烟草产品的信息，哪些策略可能有效地阻止造型和延续烟草的使用。该中心还将在烟草监管科学方面提供全面的教育，最先进的培训，并促进初级研究人员独立研究职业的发展。该中心的研究将得到设施/核心的支持，这些设施/核心将提供评估和表征烟草产品的暴露以及生物标志物的统一测量以及经过验证的心血管损伤指标。该中心的行政核心将为中心的各个方面提供科学，行政和后勤的监督，并协调集成团队科学，致力于解决FDA的研究优先事项。该中心将经过充分的努力，以对新的发展进行强大的协调研究项目，并与监管科学中心的其他中心进行合作研究。 相关性：由AHA-Tobacco监管和成瘾中心（A-TRAC）支持的研究将有助于开发和评估FDA对烟草产品调节的开发，从而有助于保护公共卫生并减少与烟草相关的疾病，残疾和死亡。

项目成果

Generally Recognized as Safe: Uncertainty Surrounding E-Cigarette Flavoring Safety.

普遍认为安全：电子烟香料安全性的不确定性。

• DOI: 10.3390/ijerph14101274
• 发表时间: 2017
• 期刊: International journal of environmental research and public health
• 作者: Sears,ClaraG;Hart,JoyL;Walker,KandiL;Robertson,RoseMarie
• 通讯作者: Robertson,RoseMarie

National assessment of recommendations from healthcare providers for smoking cessation among adults with cancer.

• DOI: 10.1016/j.canep.2021.102088
• 发表时间: 2022-06
• 期刊: CANCER EPIDEMIOLOGY
• 影响因子: 2.6
• 作者: Matulewicz, Richard S.;Feuer, Zachary;Birken, Sarah A.;V. Makarov, Danil;Sherman, Scott E.;Bjurlin, Marc A.;El Shahawy, Omar
• 通讯作者: El Shahawy, Omar

E-cigarette initiation and associated changes in smoking cessation and reduction: the Population Assessment of Tobacco and Health Study, 2013-2015.

• DOI: 10.1136/tobaccocontrol-2017-054108
• 发表时间: 2019-01
• 期刊: Tobacco control
• 影响因子: 5.2
• 作者: Berry KM;Reynolds LM;Collins JM;Siegel MB;Fetterman JL;Hamburg NM;Bhatnagar A;Benjamin EJ;Stokes A
• 通讯作者: Stokes A

Cardiovascular Perspective of the Promises and Perils of E-Cigarettes.

• DOI: 10.1161/circresaha.116.308723
• 发表时间: 2016-06-10
• 期刊: Circulation research
• 影响因子: 20.1
• 作者: Bhatnagar A

Sex differences in associations between receiving and sharing tobacco-related information and tobacco product use among Appalachian Youth.

阿巴拉契亚青少年接收和分享烟草相关信息与烟草产品使用之间关联的性别差异。

• DOI: 10.18332/popmed/125911
• 发表时间: 2020
• 期刊: Population medicine
• 作者: Mattingly,DelvonT;Pfeiffer,JackA;Walker,KandiL;Hart,JoyL
• 通讯作者: Hart,JoyL