American Heart Association Tobacco Center for Regulatory Science (A-TRAC) 2.0

项目总结 美国心脏协会(AHA)烟草监管中心(ATRAC)的总体目标是提供 与食品和药物管理局(FDA)烟草中心监管机构相关的科学数据 产品(CTP)。该中心的综合主题是评估和交流心血管效应 在健康影响、毒性和通信等科学领域内的烟草产品。研究 该中心将通过评估烟草监管科学的 烟草产品及其成分对心血管的影响。该中心将支持多学科 在体外试验和动物试验中评估烟草产品及其成分的毒性的研究计划 模型(项目1)；评估烟草产品对心血管健康的短期和长期影响(项目2) 并评估与使用非香烟烟草产品相关的心血管疾病风险 NIH支持的大型心血管队列(项目3)。以传达在 中心和其他烟草管制科学中心(TCORS)，中心将开发和测试方法 有效宣传烟草制品使用造成的心血管后果(项目4)。为了方便 一致性和质量控制，所有测量将在一个集中的生物分析和生物标记中进行 核心。中心内的研究活动将由一个行政核心协调，而职业 Enhance Core将监督新的和早期调查人员的职业发展。这个 Administration Core将与联邦合作伙伴保持密切沟通，并将监督发展， 快速反应项目的资金和进展情况。由该中心支持的研究将开发新的 了解当前、新出现的烟草产品对心血管的影响；帮助 制定信息，传达与使用烟草有关的心血管风险 建立和部署应对新发展的能力和专门知识。整体而言，居中 研究将拓宽烟草监管科学的科学基础，为FDA的烟草监管提供信息 制造、分销和营销。

PROJECT SUMMARY The overall goal of the American Heart Association (AHA) Tobacco Regulation Center (ATRAC) is to provide scientific data relevant to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). The integrative theme of the Center is to evaluate and communicate the cardiovascular effects of tobacco products, within the scientific domains of Health Effects, Toxicity and Communications. Research within the Center will contribute to the scientific base of tobacco regulatory science by evaluating the cardiovascular effects of tobacco products and their constituents. The Center will support a multi-disciplinary research program to assess the toxicity of tobacco products and their constituents in in vitro assays and animal models (Project 1); evaluate short- and long-term cardiovascular health effects of tobacco products (Project 2) and assess the cardiovascular disease risk associated with the use of non-cigarette tobacco products in multiple large NIH-supported cardiovascular cohorts (Project 3). To communicate the knowledge generated within the Center and other Tobacco Centers of Regulatory Science (TCORS), the Center will develop and test approaches for effective communication of the cardiovascular consequences of tobacco product use (Project 4). To facilitate uniformity, and quality control, all measurements will be conducted in a centralized Bioanalytical and Biomarker Core. The research activities within the Center will be coordinated by an Administrative Core, while the Career Enhancement Core will oversee the career development of new and early stage investigators. The Administrative Core will maintain close communication with federal partners and will oversee the development, funding and progress of Rapid Response Projects. Research supported by the Center will develop new understanding of the cardiovascular effects of current, new and emerging tobacco products; aid in the development of messages for communicating the cardiovascular risk associated with the use of tobacco products; and build and deploy capacity and expertise to respond to new developments. Collectively, Center research will broaden the scientific base of tobacco regulatory science to inform FDA's regulation of tobacco manufacturing, distribution and marketing.