Planning and Evaluation Core

规划与评估核心

• 批准号: 7422078
• 负责人: MARY A O'CONNELL
• 金额: $ 6.31万
• 依托单位: NEW MEXICO STATE UNIVERSITY LAS CRUCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7422078
• 关键词: AIDS/HIV problem; Achievement; Acquired Immunodeficiency Syndrome; Address; Advisory Committees; Affect; African American; Antineoplastic Agents; Antioxidants; Area; Arkansas; Award; Bachelor' s Degree; Baltimore; Basic Science; Behavior Therapy; Behavioral Sciences; Biochemistry; Biology; Biomedical Engineering; Biomedical Research; Biometry; Breast; Breast Cancer Detection; Cancer Center; Cardiovascular Diseases; Cells; Centromere; Cervical; Chemistry; Chemistry, Other; Childhood; Clinical; Clinical Trials; Collaborations; Colorado; Committee Members; Committee Membership; Conflict (Psychology); Country; Critiques; Data; Decision Making; Defect; Development; Doctor of Philosophy; Drosophila genus; Drosophila inturned protein; Drug Delivery Systems; Educational process of instructing; Endothelial Cells; Engineering; Ensure; Environment; Enzymes; Epidemiology; Epigenetic Process; Equilibrium; Evaluation; Event; Faculty; Failure; Florida; Fred Hutchinson Cancer Research Center; Funding; Future; Gene Transfer; Genetic; Genetic screening method; Genome; Genomics; Goals; Grant; Guatemala; HIV; HIV Infections; HIV-1; Health; Health Promotion; Health Sciences; Hematopoietic System; Hematopoietic stem cells; Hispanics; Human; Immune; India; Individual; Inflammatory; Institutes; Institution; Internal Medicine; International; Internships; Intervention; Interview; Joints; Knowledge; Laboratories; Latino; Lead; Leadership; Logistics; Louisiana; Mails; Malignant Neoplasms; Manganese Superoxide Dismutase; Massachusetts; Master' s Degree; Mathematics; Mechanics; Medical center; Medicine; Mentors; Mentorship; Methods; Mexico; Microbiology; Minority; Mismatch Repair; Mobile Genetic Elements; Modeling; Molecular; Molecular Biology; Molecular and Cellular Biology; Motivation; Mus; New Mexico; Numbers; Operative Surgical Procedures; Organism; Oxidants; Oxidation-Reduction; Personal Satisfaction; Persons; Pharmaceutical Preparations; Pilot Projects; Population; Procedures; Process; Proteins; Protocols documentation; Public Health; Public Health Schools; Publications; Published Comment; Recommendation; Recording of previous events; Recruitment Activity; Regulation; Reporting; Repression; Research; Research Personnel; Research Support; Resources; Ribonucleotide Reductase; Role; Running; Schedule; Schools; Science; Scientist; Screening for Prostate Cancer; Screening for cancer; Screening procedure; Site Visit; Social Health Services; South Carolina; Spain; Specific qualifier value; Structure; Students; Study Section; System; Texas; Time; Training; Tropical Medicine; United States National Institutes of Health; Universities; Vaccine Therapy; Vector-transmitted infectious disease; Viral Pathogenesis; Visit; Washington; Work; Writing; Xenograft Model; base; cancer cell; cancer chemoprevention; cancer genetics; career; chemical carcinogenesis; chemical genetics; college; colorectal cancer screening; cost; day; design; experience; gene therapy; health care service utilization; health disparity; high school; human SOD2 protein; innovation; insight; interest; member; mutant; pathogen; professor; programs; psychosocial; reconstitution; response; skills; sound; success; symposium; tat Protein; tumor; vaccine development; virology

PLANNING AND EVALUATION CORE This section describes the Planning and Evaluation Core. The overall goal of the Planning and Evaluation Core is to assess the progress of the collaboration. Toward that end, the Planning and Evaluation Core will review the various components of the partnership to ensure that the goals and objectives of the collaboration are met. The committees established in this Core will meet regularly to review and establish short- and longterm goals, progress of the projects, and will review new pilot projects for the development Core. A. Internal Processes The Internal Advisory Committee (IAC) is comprised of scientists at the FHCRC and NMSU. Each individual was selected based on his/her knowledge and expertise of areas related to this application. The IAC membership is briefly described below. New Mexico State University Members Carl Kendall. Dr. Kendall is the new holder of the Stan Fulton Endowed Chair in Health Disparities and director for the Southwest Center for Health Disparities Research. He also serves as Associate Dean for Research for the College of Health and Social Services at NMSU. Kendall is new to NMSU after a career at the Tulane University School of Public Health and Tropical Medicine in Louisiana, and The Johns Hopkins Bloomberg School of Pubic Health. Dr. Kendall received the distinguished research faculty award from Tulane for 2002, 2003, 2004 and 2005. He has collaborated with colleagues at the Tulane Cancer Center and the Louisiana Cancer Consortium where he mentored junior faculty to develop proposals to enhance breast cancer screening among African-American populations. He has collaborated with colleagues in more than 40 countries to address global problems of maternal and childhood illnesses, vector-borne diseases, and HIV/AIDS. Currently Kendall manages projects in eight countries with full-time staff in four of those countries. Dr. Kendall is fluent in Spanish and has taught university graduate courses in Spain and Guatemala. Vimal Chaitanya, Before becoming the NMSU Vice President for Research Graduate Studies and International Programs in July 2006, Dr. Chaitanya was the director of the Advanced Materials Processing and Analysis Center (AMPAC) at the University of Central Florida (UCF). He was also the director of UCF's Materials Science and Engineering program and its Materials Characterization Facility. Dr. Chaitanya received the University of Central Florida's Research Achievement Award in 2002 and the UCF Leadership Award in 1999. He is a five-time winner of his academic department's Researcher of the Year award. He has a Ph.D. in materials science and engineering from The Johns Hopkins University in Baltimore, a master's degree in bioengineering from Clemson University in South Carolina, and a bachelor's degree in mechanical engineering from M.S. University of Baroda, India. Fred Hutchinson Cancer Research Center Members Harmit S. Malik. Dr. Malik is an Assistant Member at the FHCRC and an Affiliate Assistant Professor of Genome Sciences at the University of Washington. Dr. Malik's lab is interested in evolutionary studies of genetic conflict to gain insights into their mechanisms and consequences. Genomes are a tenuous conglomerate of different genetic entities, each trying to maximize their own evolutionary success, often at great cost to their genomic neighbors. This can create problems for the host organism. To gain insights into these mechanisms, Dr. Malik's lab studies centromeres, mobile genetic elements, and rapidly evolving proteins in Drosophila. Dr. Malik will provide great expertise in biology and the drosophila studies. Julian Simon. Dr. Simon is an Associate Member at the FHCRC and an Affiliate Associate Professor in the Molecular and Cellular Biology Program at the University of Washington. The aim of his lab is to identify new anticancer drugs. This is done through using the genetic context of the cancer cell as the drug target. The second broad strategy is to use chemical genetics to find better anticancer drugs. Other projects in the lab include the study of genetic interactions of mismatch repair mutants with ribonucleotide reductase as a strategy for the identification of drugs for the treatment of tumors with mismatch repair defects. Dr. Simon was involved in the U56 and has excellent understanding of how the collaboration operates. Ad Hoc Members Whenever there is a call for new proposals within the U54 collaboration, a "study section" will be convened to review and critique the proposals. We followed this format during the U56 award and found this to be an effective way to match proposals with expertise in the areas covered by the proposal. Members from both institutions will be identified and recruited by the IAC to review proposals (see below). These reviewers will form a study section to discuss and rank the proposals received and to make recommendations for improvements. External Activities: The Program Steering Committee (PSC) Five members have been selected to serve on the PSC. They will act as advisors to the lead Pis and the NCI Project Officer. They have been selected for their skills in specific areas. Each is described below. Sonia C Flores, Ph.D. Dr. Sonia Flores is an Associate Professor in the Department of Medicine at the University of Colorado Health Sciences Center in Denver, CO. She is also the Director of the UCHSC Graduate Training for Multicultural Students Summer Internship Program. Her research interests include examination of HIV-1 Tat transcriptional protein and its pro-inflammatory effects on endothelial cells, oxidant/antioxidant balance in HIV infection, molecular mechanisms of human Mn-superoxide dismutase repression by HIV-1 Tat protein, and redox modulation of transcriptional factor activity. She has written numerous articles on these topics. Dr. Flores also serves as the advisor to a summer internship program for graduates in biology. Dr. Flores has been on the PSC for the past three years and has made invaluable contributions to some of the basic science projects. J. Victor Garcia-Martinez, Ph.D. Dr. Garcia-Martinez is a professor in the departments of Internal Medicine and Microbiology at the University of Texas, Southwestern Medical Center in Dallas, TX. He is nationally known for his skills in virology and molecular biology. His current work focuses on HIV, AIDS, and viral pathogenesis, with an emphasis on understanding the host pathogen relationship at the molecular level. From that understanding, he develops rational approaches to therapy and vaccine development. Another major interest for Dr. Garcia-Martinez is cell and gene therapy. In his laboratory, highly efficient gene transfer systems have been developed. Focusing on the human hematopoietic stem cell, his lab has developed a xenograft model to reconstitute the human hematopoietic system in immune deficient mice, allowing an excellent way to evaluate some gene therapy approaches. Dr. Garcia-Martinez received his training in Mexico, at the FHCRC, at NIH, and at MIT. He has been on the PSC for the past five years and served as PSC chair for two years, making outstanding contributions. George Hammons, Ph.D. Dr. George Hammons is Professor of Chemistry at Philander Smith College in Little Rock, Arkansas, where he has chaired the Department for the past eighteen years. He was also Director of the Minority Biomedical Research Support Program at Philander Smith for twelve years. In addition to his active engagement in the training of undergraduate students in chemistry and other sciences, he has also developed out-reach activities for junior high and high school students to encourage their participation and development in the sciences. After completing the undergraduate degree in chemistry and mathematics at Philander Smith, he received his doctoral training in biochemistry at Harvard University in Cambridge, Massachusetts. He has had research interest in the area of chemical carcinogenesis; and more recently, his research has focused on the potential role of dietary agents in cancer chemoprevention and on epigenetics in the regulation of xenobioticmetabolizing enzymes. Dr. Hammons has served on the PSC for the past two years and has made excellent contributions to the chemistry projects. Sally Vernon, Ph.D. Dr. Vernon is a Professor of Behavioral Sciences and Epidemiology at the University of Texas Health Science Center at Houston, TX and the Director of Health Promotion & Behavioral Sciences there. She has a long history of working in public health with the Latino population. She specializes in designing behavioral interventions to increase participation in cancer screening, including interventions to increase participation in breast, cervical, and colorectal cancer screening. Her work has resulted in some key publications on barriers to screening. Dr. Vernon also conducts studies of informed decision making for prostate cancer screening. She does research on the psychosocial aspects of cancer genetic testing, seeking out motivations for having or not having genetic testing. Dr. Vernon has been on the PSC for the past four years and has made outstanding contributions, especially to the public health projects. N. David Yanez, Ph.D. Dr. Yanez is an Associate Professor of Biostatistics and the Director of the Graduate Program in Biostatistics at the University of Washington in Seattle, WA. Dr. Yanez's research interests include analysis of overdispersed data, joint modeling of mean and dispersion parameters, and quasi-likelihood models. His research has included examination of the costs of health care utilization, numerous articles on the effects of cardiovascular disease, and the examination of statistical errors in longitudinal data. He also has collaborated on a careful assessment of the effects of clinical trials on clinical practice. Dr. Yanez has participated in a number of clinical trials and is well-known for his expertise in applied biostatistics. In short, Dr. Yanez has a broad understanding of biostatistics as they apply to many different areas of interest. In addition, Dr. Yanez has been the faculty sponsor for L'PROGRESO, an organization of graduate and professional Latino students of the sciences at the University of Washington since 1995. He has been key in providing mentorship for Latino students. Dr. Yanez has been on the PSC since the U56 was funded and has made outstanding contributions.

计划和评估核心 本节描述了计划和评估核心。计划和评估的总体目标 核心是评估协作的进度。为此，计划和评估核心将 查看合作伙伴关系的各个组成部分，以确保协作的目标和目标 被满足。在此核心中成立的委员会将定期开会，以审查和建立短期和长期的委员会 目标，项目的进度，并将审查开发核心的新试点项目。 A.内部过程 内部咨询委员会（IAC）由FHCRC和NMSU的科学家组成。每个人 根据他/她的知识和与此应用程序相关领域的知识和专业知识选择。 IAC 会员资格将在下面简要介绍。 新墨西哥州立大学成员 卡尔·肯德尔。肯德尔博士是斯坦·富尔顿卫生差异主席和董事的新持有人 西南健康差异研究中心。他还担任研究副院长 NMSU卫生与社会服务学院。肯德尔（Kendall）在杜兰（Tulane）的职业生涯后是NMSU的新手 路易斯安那州大学公共卫生与热带医学学院和约翰·霍普金斯彭博 公共健康学院。肯德尔博士获得了2002年杜兰的杰出研究学院奖， 2003年，2004年和2005年。他与杜兰癌中心和路易斯安那州的同事合作 癌症联盟，他指导了初级教师，以开发提案以增强乳腺癌筛查 在非裔美国人中。他已经与40多个国家的同事合作 解决孕产妇和儿童疾病，媒介传播疾病和艾滋病毒/艾滋病的全球问题。现在 肯德尔（Kendall）在其中四个国家 /地区拥有全职员工的八个国家的项目。肯德尔博士很流利 在西班牙语中，并在西班牙和危地马拉任教了大学的研究生课程。 Vimal Chaitanya，在成为NMSU研究研究生研究副总裁和国际 计划于2006年7月，Chaitanya博士是高级材料处理和分析的主任 中央佛罗里达大学（UCF）的中心（AMPAC）。他还是UCF材料的主任 科学与工程计划及其材料表征设施。 Chaitanya博士收到了 中央佛罗里达大学的研究成就奖，2002年，并于1999年获得UCF领导力奖。 他曾五次获得学术部年度研究员奖。他有博士学位在 巴尔的摩约翰·霍普金斯大学的材料科学与工程学，硕士学位 来自南卡罗来纳州克莱姆森大学的生物工程，以及机械工程学士学位 来自M.S.印度巴罗达大学。 弗雷德·哈钦森癌症研究中心成员 Harmit S. Malik。 Malik博士是FHCRC的助理成员，也是一位会员助理教授 华盛顿大学的基因组科学。马利克博士的实验室对 遗传冲突以深入了解其机制和后果。基因组很脆 不同遗传实体的集团，每个遗传实体都试图最大化自己的进化成功，通常 基因组邻居的巨大成本。这可能会给宿主生物带来问题。洞悉 这些机制，Malik博士的实验室研究集中粒，移动遗传元素和迅速发展的蛋白质 在果蝇中。 Malik博士将在生物学和果蝇研究方面提供丰富的专业知识。 朱利安·西蒙（Julian Simon）。 Simon博士是FHCRC的副成员，也是该会员的副教授 华盛顿大学的分子和细胞生物学计划。他的实验室的目的是确定新的 抗癌药。这是通过使用癌细胞的遗传环境作为药物靶标完成的。这 第二个广泛的策略是使用化学遗传学来寻找更好的抗癌药。实验室中的其他项目 包括研究不匹配修复突变体与核糖核苷酸还原酶的遗传相互作用作为一种策略 用于鉴定药物以治疗与不匹配修复缺陷的肿瘤。西蒙博士参与了 在U56中，对协作的运作方式有很好的了解。 临时成员每当有U54协作中提出新建议时，“研究部分” 将召集以审查和批评提案。我们在U56奖上遵循这种格式， 发现这是将建议与该提案所涵盖的领域专业知识相匹配的有效方法。 IAC将确定和招募两个机构的成员来审查提案（见下文）。 这些审阅者将组成一个研究部分，以讨论和对收到的建议进行排名 改进的建议。 外部活动：计划指导委员会（PSC） 选择了五名成员在PSC上任职。他们将担任PIS和NCI的顾问 项目官员。他们在特定领域的技能被选中。每个都在下面描述。 Sonia C Flores博士Sonia Flores博士是医学系的副教授 科罗拉多大学健康科学科学中心，她还是UCHSC的主任 多元文化学生的研究生培训暑期实习计划。她的研究兴趣包括 检查HIV-1 TAT转录蛋白及其对内皮细胞的促炎作用， 艾滋病毒感染中的氧化剂/抗氧化剂平衡，人类MN-塞氧化物歧化酶的分子机制 HIV-1 TAT蛋白的抑制和转录因子活性的氧化还原调节。她写了 有关这些主题的许多文章。弗洛雷斯博士还担任暑期实习计划的顾问 生物学的毕业生。弗洛雷斯博士在过去三年中一直在PSC上担任PSC，并变得无价 对一些基础科学项目的贡献。 J. Victor Garcia-Martinez博士Garcia-Martinez博士是内科部门的教授 德克萨斯大学，德克萨斯州西南医学中心的微生物学。他在全国范围内 以他在病毒学和分子生物学方面的技能而闻名。他目前的工作着重于艾滋病毒，艾滋病和病毒 发病机理，重点是理解分子水平的宿主病原体关系。从 他的理解发展了治疗和疫苗开发的合理方法。另一个专业 Garcia-Martinez博士的兴趣是细胞和基因治疗。在他的实验室，高效的基因转移 系统已经开发。专注于人类造血干细胞，他的实验室已经发展了 异种移植模型重建免疫缺陷小鼠中人类造血系统，从而使 评估某些基因疗法方法的绝佳方法。 Garcia-Martinez博士在墨西哥接受了培训 在FHCRC，NIH和麻省理工学院。在过去的五年中，他一直在PSC担任PSC，并担任PSC主席 两年来，做出了杰出的贡献。 乔治·哈蒙斯（George Hammons）博士乔治·哈蒙斯（George Hammons 阿肯色州的洛克（Rock），在过去的18年中，他担任了该部门的主席。他还是 菲兰德·史密斯（Philander Smith）的少数族裔生物医学研究支持计划已有十二年。除了他的活跃 从事化学和其他科学的本科生的培训，他还发展了 初中和高中生的活动超出活动，以鼓励他们的参与和发展 科学。在菲兰德·史密斯（Philander Smith）完成化学和数学学士学位后，他 在马萨诸塞州剑桥的哈佛大学接受了他的生物化学培训。他有 研究化学癌变领域的兴趣；最近，他的研究重点是 饮食剂在癌症化学预防和表观遗传学中的潜在作用在异种生物量化的调节中 酶。 Hammons博士在过去两年中一直在PSC任职，并表现出色 对化学项目的贡献。 莎莉·弗农（Sally Vernon）博士弗农博士是大学行为科学与流行病学教授 德克萨斯州休斯敦的德克萨斯健康科学中心和健康促进与行为科学主任 那里。她在拉丁美洲人的公共卫生工作中有悠久的历史。她专门研究 设计行为干预措施以增加参与癌症筛查的参与，包括 增加参与乳房，宫颈癌和大肠癌筛查。她的工作导致了一些钥匙 有关筛查障碍的出版物。弗农博士还对明智的决策做出研究 前列腺癌筛查。她对癌症基因检测的社会心理方面进行了研究，寻求 消除进行基因检测或没有基因检测的动机。弗农博士在过去的四个中一直在PSC上 多年，尤其是对公共卫生项目做出了杰出的贡献。 N. David Yanez博士Yanez博士是生物统计学副教授和研究生主任 华盛顿州西雅图的华盛顿大学生物统计学计划。 Yanez博士的研究兴趣包括 分散分散数据，平均值和分散参数的联合建模以及准模型的分析 型号。他的研究包括检查医疗保健利用成本，许多有关 心血管疾病的影响以及纵向数据中统计错误的检查。他也有 仔细评估临床试验对临床实践的影响。 Yanez博士有 参加了许多临床试验，并以其应用生物统计学专业知识而闻名。简而言之 Yanez对生物统计学有广泛的了解，因为它们适用于许多不同感兴趣的领域。此外， Yanez博士一直是L'Progreso的教师赞助者，该组织是研究生和专业的组织 自1995年以来 拉丁裔学生的指导。自U56获得资助以来，Yanez博士一直在PSC上 出色的贡献。