PHENOTYPING CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 临床表型/患者样本核心将简化JABSOM的PRCEHD研究人员和其他临床研究人员对临床数据和患者样本的访问。CORE的临床表型部分包括一个新的围产期/新生儿数据库，一个新的胎盘库，以及标准化新生儿检查和改进的新生儿跟踪能力选项。这一核心的患者样本部分将提供潜在研究对象的确定和招募、相关样本的持续收集，以及向调查人员提供样本和将材料存储在样本储存库中的有效方案。最后，核心实验室将为当前和未来的项目提供基本和先进的病理学技术。该中心的具体目标是：1)建立一个以围产期和新生儿状况为重点的新的研究数据库；2)储存所有未经主治医生或助产士要求进行标准病理检查的高危妊娠的胎盘数据和样本；3)为选定的新生儿提供一致和详细的体检和人体测量；4)收集、获取、存档，并向CCRE调查员分发产科和新生儿患者的高质量组织和血液样本及相关临床数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Clinical Phenotype/Patient Sample Core will streamline access to clinical data and patient samples for the PRCEHD investigators and other clinical investigators at JABSOM. The clinical phenotyping component of the Core consists of a new perinatal/neonatal database, a new placental bank, and the option for a standardized neonatal examination and improved neonatal follow-up capability. The patient sample component of this Core will provide ascertainment and recruitment of potential research subjects, ongoing collection of relevant specimens, and efficient protocols to provide specimens to investigators and to store materials in a sample repository. Finally, the core laboratory will offer basic and advanced pathology techniques to current and future projects. The specific aims of this core are: 1) to build a new research database focused on perinatal and neonatal conditions, 2) to bank placental data and samples for all high-risk pregnancies for which standard pathological examinations were not requested by the attending physician or midwife, 3) to provide consistent and detailed physical examinations and anthropomorphic measurements on selected neonates, 4) to collect, access, archive, and distribute to the CCRE investigators high-quality tissue and blood specimens and relevant clinical data from obstetric and neonatal patients.