PHENOTYPING CORE

表型核心

• 批准号: 7380801
• 负责人: KENNETH WARD
• 金额: $ 66.92万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380801
• 关键词: PHENOTYPING; CORE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Clinical Phenotype/Patient Sample Core will streamline access to clinical data and patient samples for the PRCEHD investigators and other clinical investigators at JABSOM. The clinical phenotyping component of the Core consists of a new perinatal/neonatal database, a new placental bank, and the option for a standardized neonatal examination and improved neonatal follow-up capability. The patient sample component of this Core will provide ascertainment and recruitment of potential research subjects, ongoing collection of relevant specimens, and efficient protocols to provide specimens to investigators and to store materials in a sample repository. Finally, the core laboratory will offer basic and advanced pathology techniques to current and future projects. The specific aims of this core are: 1) to build a new research database focused on perinatal and neonatal conditions, 2) to bank placental data and samples for all high-risk pregnancies for which standard pathological examinations were not requested by the attending physician or midwife, 3) to provide consistent and detailed physical examinations and anthropomorphic measurements on selected neonates, 4) to collect, access, archive, and distribute to the CCRE investigators high-quality tissue and blood specimens and relevant clinical data from obstetric and neonatal patients.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。临床表型/患者样本核心将简化PRCEHD研究者和JABSOM其他临床研究者对临床数据和患者样本的访问。核心的临床表型组成部分包括一个新的围产期/新生儿数据库，一个新的胎盘库，以及标准化新生儿检查和改善新生儿随访能力的选项。该核心的患者样本部分将提供潜在研究对象的确定和招募、相关样本的持续收集以及向研究人员提供样本并将材料存储在样本库中的有效协议。最后，核心实验室将为当前和未来的项目提供基础和先进的病理学技术。该核心的具体目标是：1）建立一个新的研究数据库，重点是围产期和新生儿状况，2）为主治医生或助产士没有要求进行标准病理检查的所有高危妊娠储存胎盘数据和样本，3）对选定的新生儿提供一致和详细的体格检查和拟人测量，4）收集、访问、存档，并向CCRE调查人员分发高质量的组织和血液标本以及产科和新生儿患者的相关临床数据。