PHENOTYPING CORE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。临床表型/患者样本核心将为太平洋早期人类发展研究中心（PRCEHD）的研究人员和JABSOM的其他临床研究人员简化临床数据和患者样本的访问。Core的临床表型组成部分包括一个新的围产期/新生儿数据库，一个新的胎盘库，以及标准化新生儿检查的选择和改进的新生儿随访能力。该核心的患者样本部分将提供确定和招募潜在研究对象、持续收集相关标本、向调查人员提供标本和随附临床数据（必要时）的有效方案，以及在样本库中存储材料。最后，核心实验室将为当前和未来的项目提供基础和先进的病理技术。这一核心的具体目标是：1)建立一个新的围产期和新生儿疾病研究数据库；2)为所有未被主治医生或助产士要求进行标准病理检查的高危妊娠提供胎盘数据和样本；3)为选定的新生儿提供一致和详细的体格检查和拟人测量；4)收集、获取、存档；并向CCRE调查员分发来自产科和新生儿患者的高质量组织和血液标本以及相关临床数据。对儿童权利委员会人员和设施支持的请求仅限于实施具体目标4)（如上所列）。核心项目不直接涉及人类实验对象。该核心的目标是招募所有在卡皮奥拉尼妇女儿童医疗中心（KMCWC）分娩的妇女。临床研究中心（CRC）参与的研究包括收集母体血液样本或颊拭子（类似于棉签）、脐带血样本和胎盘；并将这些组织运送到JABSOM临床表型/患者样本核心实验室。所有组织样本和个人信息将安全保存在JABSOM临床表型/患者样本核心实验室，以供研究使用。所有潜在的研究对象将是Kapi¿olani妇女和儿童医疗中心的孕妇或最近分娩的住院患者。受试者年龄在18-50岁之间，能够读、说、理解英语。我们不会把被监禁的女性纳入这项研究。在收集个人健康信息和生物医学组织之前，所有受试者都将被登记并同意。所有受试者在精神上都能够理解同意过程和研究程序。本研究中没有种族排除。种族背景记录将成为患者数据库的一部分，以便对这一因素进行分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Clinical Phenotype/Patient Sample Core will streamline access to clinical data and patient samples for the Pacific Research Center for Early Human Development (PRCEHD) investigators and other clinical investigators at JABSOM. The clinical phenotyping component of the Core consists of a new perinatal/neonatal database, a new placental bank, and the option for a standardized neonatal examination and improved neonatal follow-up capability. The patient sample component of this Core will provide ascertainment and recruitment of potential research subjects, ongoing collection of relevant specimens, efficient protocols to provide specimens and accompanying clinical data (as necessary) to investigators, and storage of materials in a sample repository. Finally, the core laboratory will offer basic and advanced pathology techniques to current and future projects. The specific aims of this Core are: 1) to build a new research database focused on perinatal and neonatal conditions, 2) to bank placental data and samples for all high-risk pregnancies for which standard pathological examinations were not requested by the attending physician or midwife, 3) to provide consistent and detailed physical examinations and anthropomorphic measurements on selected neonates, 4) to collect, access, archive, and distribute to the CCRE investigators high-quality tissue and blood specimens and relevant clinical data from obstetric and neonatal patients. This request for CRC personnel and facilities support is limited to the implementation of specific aim 4) (as listed above). The Core does not directly involve human subjects in experiments. The objective of this Core is to recruit all women delivering at Kapi¿olani Medical Center for Women and Children (KMCWC). The Clinical Research Center¿s (CRC¿s) involvement in the study includes the collection of maternal blood samples or cheek swabs (similar to a Q-tip), cord blood samples, and placentas; and the transporting of these tissues to the JABSOM Clinical Phenotype/ Patient Sample Core Lab. All tissue samples and personal information will be securely maintained at the JABSOM Clinical Phenotype/Patient Sample Core laboratory for research use. All potential subjects will be pregnant, or recently delivered, inpatients at Kapi¿olani Medical Center for Women and Children. The subjects will be 18-50 years of age, and will be able to read, speak and understand English. We will not include incarcerated women in this study. All subjects will be enrolled and consented prior to the collection of their personal health information and biomedical tissues. All subjects will be mentally competent to understand the consent process and the study procedures. There are no ethnic exclusions in this study. A record of ethnic background will be part of the patient database so that this factor can be analyzed.