PHENOTYPING CORE

表型核心

• 批准号: 7609613
• 负责人: KENNETH WARD
• 金额: $ 13.48万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609613
• 关键词: Age-Years; Archives; Blood specimen; Cheek structure; Child; Clinical Data; Clinical Investigator; Clinical Research; Collection; Computer Retrieval of Information on Scientific Projects Database; Condition; Consent; Data; Databases; Discipline of obstetrics; Enrollment; Exclusion; Funding; Future; Grant; Health; High-Risk Pregnancy; Human Development; Human Resources; Inpatients; Institution; Laboratories; Laboratory Research; Measurement; Medical center; Midwife; Neonatal; Pathology; Patient currently pregnant; Patients; Perinatal; Phenotype; Physical Examination; Physicians; Placenta; Procedures; Process; Protocols documentation; Reading; Recruitment Activity; Research; Research Personnel; Research Subjects; Resources; Sampling; Source; Specimen; Standards of Weights and Measures; Swab; Techniques; Tissue Sample; Tissues; United States National Institutes of Health; Woman; clinical phenotype; follow-up; human subject; improved; neonate; repository; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Clinical Phenotype/Patient Sample Core will streamline access to clinical data and patient samples for the Pacific Research Center for Early Human Development (PRCEHD) investigators and other clinical investigators at JABSOM. The clinical phenotyping component of the Core consists of a new perinatal/neonatal database, a new placental bank, and the option for a standardized neonatal examination and improved neonatal follow-up capability. The patient sample component of this Core will provide ascertainment and recruitment of potential research subjects, ongoing collection of relevant specimens, efficient protocols to provide specimens and accompanying clinical data (as necessary) to investigators, and storage of materials in a sample repository. Finally, the core laboratory will offer basic and advanced pathology techniques to current and future projects. The specific aims of this Core are: 1) to build a new research database focused on perinatal and neonatal conditions, 2) to bank placental data and samples for all high-risk pregnancies for which standard pathological examinations were not requested by the attending physician or midwife, 3) to provide consistent and detailed physical examinations and anthropomorphic measurements on selected neonates, 4) to collect, access, archive, and distribute to the CCRE investigators high-quality tissue and blood specimens and relevant clinical data from obstetric and neonatal patients. This request for CRC personnel and facilities support is limited to the implementation of specific aim 4) (as listed above). The Core does not directly involve human subjects in experiments. The objective of this Core is to recruit all women delivering at Kapiolani Medical Center for Women and Children (KMCWC). The Clinical Research Centers (CRCs) involvement in the study includes the collection of maternal blood samples or cheek swabs (similar to a Q-tip), cord blood samples, and placentas; and the transporting of these tissues to the JABSOM Clinical Phenotype/ Patient Sample Core Lab. All tissue samples and personal information will be securely maintained at the JABSOM Clinical Phenotype/Patient Sample Core laboratory for research use. All potential subjects will be pregnant, or recently delivered, inpatients at Kapiolani Medical Center for Women and Children. The subjects will be 18-50 years of age, and will be able to read, speak and understand English. We will not include incarcerated women in this study. All subjects will be enrolled and consented prior to the collection of their personal health information and biomedical tissues. All subjects will be mentally competent to understand the consent process and the study procedures. There are no ethnic exclusions in this study. A record of ethnic background will be part of the patient database so that this factor can be analyzed.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 临床表型/患者样本核心将简化太平洋人类早期发育研究中心（PRCEHD）研究者和JABSOM其他临床研究者对临床数据和患者样本的访问。 核心的临床表型组成部分包括一个新的围产期/新生儿数据库，一个新的胎盘库，以及标准化新生儿检查和改善新生儿随访能力的选项。 本核心的患者样本部分将提供潜在研究受试者的确定和招募、相关样本的持续收集、向研究者提供样本和随附临床数据（必要时）的有效方案，以及样本库中材料的储存。 最后，核心实验室将为当前和未来的项目提供基础和先进的病理学技术。 该核心的具体目标是：1）建立一个新的研究数据库，重点是围产期和新生儿状况，2）为主治医生或助产士没有要求进行标准病理检查的所有高危妊娠储存胎盘数据和样本，3）对选定的新生儿提供一致和详细的体格检查和拟人测量，4）收集、访问、存档，并向CCRE调查人员分发高质量的组织和血液标本以及产科和新生儿患者的相关临床数据。 对CRC人员和设施支持的这一请求仅限于实现具体目标4）（如上所列）。 内核并不直接让人类参与实验。 该核心的目标是招募所有在卡皮分娩的妇女奥拉尼妇女和儿童医疗中心（KMCWC）。 临床研究中心s（CRC参与研究的人员包括采集母体血液样本或颊拭子（类似于棉签）、脐带血样本和胎盘;并将这些组织运送至JABSOM临床表型/患者样本核心实验室。 所有组织样本和个人信息将安全保存在JABSOM临床表型/患者样本核心实验室，以供研究使用。 所有潜在受试者均为妊娠或近期分娩的Kapi住院患者奥拉尼妇幼医疗中心。受试者年龄在18-50岁之间，能够读、说和理解英语。我们不会将被监禁的女性纳入这项研究。所有受试者将在收集其个人健康信息和生物医学组织之前入组并签署知情同意书。 所有受试者均具有理解知情同意过程和研究程序的心智能力。 本研究中没有种族排除。 种族背景记录将作为患者数据库的一部分，以便分析该因素。