Episodic memory encoding: fMRI investigations

描述（由申请人提供）：获取和检索独特事件记忆的能力被称为“情景记忆”。情景记忆障碍在许多神经系统疾病中都很突出。情景记忆功能障碍也见于主要精神疾病，包括精神分裂症和抑郁症。情景记忆障碍的特征，阐明其在不同疾病病因中的作用，以及制定补救措施，需要了解支持情景记忆的认知操作及其神经基础。拟议的研究将通过调查情景记忆编码——当经历一个事件时所参与的过程，从而导致对该事件的持久记忆——来促进这一理解。功能性磁共振成像将用于研究与事件相关的神经活动，这些活动可以预测事件是否会在以后被记住。这种神经活动的差异被称为“后续记忆效应”，是成功编码的候选神经相关因素。实验将进行调查：i)编码的语义和非语义介导的项目-上下文关联；Ii)单个与多个上下文属性的编码；Iii)研究-测试相容性效应；Iv)对编码的一般干扰与特定领域干扰；5)刺激前后记忆效应的关系。

DESCRIPTION (provided by applicant): The capacity to acquire and retrieve memories of unique events is termed 'episodic memory'. Impairments of episodic memory are prominent in numerous neurological conditions. Episodic memory dysfunction is also found in major psychiatric disorders, including schizophrenia and depression. The characterization of episodic memory impairments, elucidation of their roles in the etiology of different disorders, and the development of remedial measures, require an understanding of the cognitive operations that support episodic memory and their neural underpinnings. The proposed research will contribute to this understanding by investigating episodic memory encoding-the processes engaged when an event is experienced that result in a durable memory for the event. Functional magnetic resonance imaging will be employed to investigate event-related neural activity that is predictive of whether or not the event will be later remembered. Such differences in neural activity are termed 'subsequent memory effects', and are candidate neural correlates of successful encoding. Experiments will be conducted to investigate: i) encoding of semantically vs. non-semantically mediated item-context associations; ii) encoding of single versus multiple contextual attributes; iii) study-test compatibility effects; iv) general vs. domain-specific interference with encoding; v) the relationship between pre- and post-stimulus subsequent memory effects.