Clinical Trials Laboratory

临床试验实验室核心(CTLC)的目标是促进高质量的转化性研究 在H.Lee Moffitt癌症中心和研究所工作。CTLC旨在提供一种综合的 基础科学和临床研究计划的资源。这个CTLC有能力测量 新型化疗药物的药代动力学药物浓度及其测量和靶向分子 终端。CTLC还提供了许多液体的收集和简单样品处理的手段 用于药代动力学测量的样本。CTLC由三个独立但相关的 实验室。层析和质谱学推动临床药理实验室(CPL) 进行药代动力学分析。翻译研究实验室(TRL)提供的分析方法包括 细胞凋亡检测，Western Blot分析，凝胶移动位移分析(EMSA)和 核糖核酸酶保护试验(RPA)用于分子终点分析。临床研究单位 实验室(CRU实验室)使研究人员能够在 位于临床研究单位内，这里是莫菲特进行I期和II期临床试验的首选单位 涉及研究抽样。将这些实验室合并到一个核心设施中有助于 在莫菲特，研究人员更好地进行研究，实现他们的预防和治疗目标。这个 CTLC的目标是提供有效和适当的生物样本收集，执行敏感和 具体分析，并提供对生成的数据进行建模的能力。

The objective of the Clinical Trials Laboratory Core (CTLC) is to facilitate high quality translational research at the H. Lee Moffitt Cancer Center and Research Institute. The CTLC is designed to provide a combined resource for the Basic Science and Clinical Investigations programs. This CTLC has the ability to measure pharmacokinetic drug levels of novel chemotherapeutic agents and to measure and target molecular endpoints. The CTLC also provides a means of collection and simple sample processing of many liquid samples utilized for pharmacokinetic measurement. The CTLC is composed of three separate, but related laboratories. Chromatography and Mass Spectrometry drive the Clinical Pharmacology Lab (CPL) where pharmacokinetic analysis takes place. The Translational Research Lab (TRL) provides assays such as Apoptosis measurements, Western Blot analysis, Electrophoretic Mobile Shift Assays (EMSA) and Ribonuclease Protection Assay (RPA) for molecular endpoint analysis. The Clinical Research Unit Laboratory (CRU Lab) allows investigators the ability to have their samples obtained and processed in a location within the Clinical Research Unit, the unit of choice here at Moffitt for phase I and II clinical trials involving research sampling. The combination of these laboratories within one core facility helps investigators better perform their research and attain their goals of prevention and cure here at Moffitt. The CTLC goals are to provide efficient and proper collection of biological samples, perform sensitive and specific assays and provide the ability to model the data generated.