Moffitt Cancer Center Support Grant

莫菲特癌症中心支持补助金

• 批准号: 7934869
• 负责人: William Steven Dalton
• 金额: $ 112.39万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7934869
• 关键词: Moffitt; Cancer; Center; Support; Grant

DESCRIPTION (provided by applicant): Twenty years after opening, the H. Lee Moffitt Cancer Center & Research Institute is submitting its second competitive renewal application for its Cancer Center Support Grant for grant years 10 through 14. The Center's mission remains solely focused on "contributing to the prevention and cure of cancer." The Moffitt Cancer Center, a freestanding, not-for-profit corporation located on the University of South Florida campus in Tampa, Florida, includes a research institute coupled with a 162-bed inpatient facility, an active outpatient clinic with more than 200,000 patient visits per year, a high-risk screening and prevention center, a dedicated Clinical Research Unit for early phase studies, an affiliate network of Florida hospitals and oncology practices and a wide array of outreach and educational activities. The Cancer Center has five scientific programs, all with a translational focus; 14 shared resources (five newly proposed), and a research infrastructure that supports innovative, translational research and enhances interactions among basic scientists, population-based scientists and clinical investigators. Research programs include Molecular Oncology & Drug Discovery, Immunology, Experimental Therapeutics, Risk Assessment, Detection & Intervention, and Health Outcomes & Behavior. Shared resources include Flow Cytometry, Molecular Biology, Microarray, Proteomics, High Throughput Screening & Chemistry, Mouse Models, Analytic Microscopy, Tissue, Cell Therapies, Survey Methods, Informatics, Biostatistics, Clinical Research Support Services and the Clinical Trials Laboratory Core. The Protocol Review & Monitoring System includes two Scientific Review Committees and a separate Protocol Monitoring Committee. Protocol specific support for a large-volume early phase clinical trial portfolio is also requested. During the period since designation as an NCI Comprehensive Cancer Center and the current CCSG submission (2001-2006), the Center has more than doubled its peer reviewed funding and increased NCI funding from $10.6 million to $29 million total dollars; increased accrual to phase I investigator-authored clinical trials from 130 to 534 annually and enrollment on all trials to more than 6,000; opened the Stabile Research Building to nearly double available research space; and created a network of 16 affiliate hospitals and 380 physicians throughout Florida. The Center's 135 members collaborate extensively with 25% of total publications being inter-programmatic.

描述（由申请人提供）：开业二十年后，H. Lee Moffitt 癌症中心及研究所正在提交其第二次竞争性更新申请，申请其癌症中心支持补助金，资助期为 10 至 14 年。该中心的使命仍然只专注于“为癌症的预防和治疗做出贡献”。莫菲特癌症中心是一家独立的非营利性公司，位于佛罗里达州坦帕市的南佛罗里达大学校园，包括一个研究所、一个拥有 162 个床位的住院设施、一个每年接待超过 200,000 名患者的活跃门诊诊所、一个高风险筛查和预防中心、一个用于早期研究的专用临床研究单位、佛罗里达州医院的附属网络和 肿瘤学实践以及广泛的外展和教育活动。 癌症中心有五个科学项目，全部以转化为重点； 14 个共享资源（5 个新提议）以及支持创新、转化研究并加强基础科学家、人口科学家和临床研究人员之间互动的研究基础设施。研究项目包括分子肿瘤学和药物发现、免疫学、实验治疗、风险评估、检测和干预以及健康结果和行为。共享资源包括流式细胞术、分子生物学、微阵列、蛋白质组学、高通量筛选和化学、小鼠模型、分析显微镜、组织、细胞疗法、调查方法、信息学、生物统计学、临床研究支持服务和临床试验实验室核心。方案审查和监测系统包括两个科学审查委员会和一个单独的方案监测委员会。还要求对大量早期临床试验组合提供特定于方案的支持。 自被指定为 NCI 综合癌症中心以及当前向 CCSG 提交文件以来（2001-2006 年），该中心的同行评审资金增加了一倍多，NCI 资金总额从 1,060 万美元增加到 2,900 万美元；将每年由研究者撰写的 I 期临床试验数量从 130 项增加到 534 项，所有试验的入组人数增加到 6,000 多人；开放稳定研究大楼，使可用研究空间几乎增加一倍；并在佛罗里达州创建了一个由 16 家附属医院和 380 名医生组成的网络。该中心的 135 名成员广泛合作，出版物总数的 25% 是跨项目的。