Moffitt Cancer Center Support Grant

莫菲特癌症中心支持补助金

• 批准号: 7934816
• 负责人: William Steven Dalton
• 金额: $ 34.41万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7934816
• 关键词: Moffitt; Cancer; Center; Support; Grant

DESCRIPTION (provided by applicant): Twenty years after opening, the H. Lee Moffitt Cancer Center & Research Institute is submitting its second competitive renewal application for its Cancer Center Support Grant for grant years 10 through 14. The Center's mission remains solely focused on "contributing to the prevention and cure of cancer." The Moffitt Cancer Center, a freestanding, not-for-profit corporation located on the University of South Florida campus in Tampa, Florida, includes a research institute coupled with a 162-bed inpatient facility, an active outpatient clinic with more than 200,000 patient visits per year, a high-risk screening and prevention center, a dedicated Clinical Research Unit for early phase studies, an affiliate network of Florida hospitals and oncology practices and a wide array of outreach and educational activities. The Cancer Center has five scientific programs, all with a translational focus; 14 shared resources (five newly proposed), and a research infrastructure that supports innovative, translational research and enhances interactions among basic scientists, population-based scientists and clinical investigators. Research programs include Molecular Oncology & Drug Discovery, Immunology, Experimental Therapeutics, Risk Assessment, Detection & Intervention, and Health Outcomes & Behavior. Shared resources include Flow Cytometry, Molecular Biology, Microarray, Proteomics, High Throughput Screening & Chemistry, Mouse Models, Analytic Microscopy, Tissue, Cell Therapies, Survey Methods, Informatics, Biostatistics, Clinical Research Support Services and the Clinical Trials Laboratory Core. The Protocol Review & Monitoring System includes two Scientific Review Committees and a separate Protocol Monitoring Committee. Protocol specific support for a large-volume early phase clinical trial portfolio is also requested. During the period since designation as an NCI Comprehensive Cancer Center and the current CCSG submission (2001-2006), the Center has more than doubled its peer reviewed funding and increased NCI funding from $10.6 million to $29 million total dollars; increased accrual to phase I investigator-authored clinical trials from 130 to 534 annually and enrollment on all trials to more than 6,000; opened the Stabile Research Building to nearly double available research space; and created a network of 16 affiliate hospitals and 380 physicians throughout Florida. The Center's 135 members collaborate extensively with 25% of total publications being inter-programmatic.

描述(由申请人提供)：H.Lee Moffitt癌症中心和研究所开业20年后，正在提交其癌症中心支持赠款的第二次竞争性续签申请，从第10年到第14年。该中心的使命仍然只专注于“为癌症的预防和治疗做出贡献”。莫菲特癌症中心是一家独立的非营利性公司，位于佛罗里达州坦帕市的南佛罗里达大学校区，包括一个研究所和一个162个床位的住院设施，一个活跃的门诊诊所，每年有20多万名患者就诊，一个高风险筛查和预防中心，一个专门进行早期研究的临床研究单位，一个佛罗里达州医院和肿瘤学实践的附属网络，以及一系列的外联和教育活动。 癌症中心有五个以翻译为重点的科学项目；14个共享资源(新提出的五个)，以及一个研究基础设施，支持创新的翻译研究，并加强基础科学家、基于群体的科学家和临床研究人员之间的互动。研究项目包括分子肿瘤学和药物发现、免疫学、实验治疗学、风险评估、检测和干预以及健康结果和行为。共享的资源包括流式细胞术、分子生物学、微阵列、蛋白质组学、高通量筛选和化学、小鼠模型、分析显微镜、组织、细胞疗法、调查方法、信息学、生物统计学、临床研究支持服务和临床试验实验室核心。议定书审查和监测系统包括两个科学审查委员会和一个单独的议定书监测委员会。还要求为大容量早期临床试验组合提供特定方案的支持。 在被指定为NCI综合癌症中心和目前CCSG提交的文件(2001-2006)期间，该中心的同行评审资金翻了一番以上，NCI资金总额从1060万美元增加到2900万美元；I期研究员撰写的临床试验的应计利润从每年130项增加到534项，所有试验的登记人数增加到6,000多人；Stabile研究大楼开放，可用的研究空间几乎增加了一倍；并在佛罗里达州建立了一个由16家附属医院和380名医生组成的网络。该中心的135名成员广泛合作，25%的出版物是跨计划的。