ES CELL TRANSPLANTATION AND PARKINSON?S DISEASE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。为了验证从胚胎干细胞分化的神经前体细胞移植到非人灵长类动物脑中可减轻帕金森病症状的假设。 注射MPTP诱发偏侧帕金森症状。将从人或恒河猴胚胎干细胞分化的神经前体细胞移植到纹状体和黑质。假手术对照组动物接受相同的手术，但没有神经前体细胞。结果表明，移植的神经前体细胞存活长达5个月，转化为多巴胺神经元，并减轻帕金森病症状。这些初步的观察结果显示了胚胎干细胞在人类临床治疗中的潜在用途。这项工作作为神经科学学会第35届年会的摘要提出。本研究使用动物服务和研究服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To test the hypothesis that neural precursor cells differentiated from embryonic stem cells and transplanted into the brain alleviates Parkinsonian symptoms in nonhuman primates. Hemi-parkinsonian symptoms were induced by MPTP injection. Neural precursor cells differentiated from human or rhesus embryonic stem cells were transplanted into the striatum and substantia nigra. Sham control animals received the same surgery, but no neural precursor cells. Results suggested that transplantation of neural precursor cells survived for up to 5 months, transformed into dopamine neurons, and alleviated Parkinsonian symptoms. These preliminary observations show potential use of embryonic stem cells for human clinical treatments. Work presented as an abstract of the 35th Annual Meeting of the Society for Neuroscience. This research used Animal Services and Research Services.