ES CELL TRANSPLANTATION AND PARKINSON?S DISEASE

ES 细胞移植与帕金森病

• 批准号: 7349405
• 负责人: Ei Terasawa-Grilley
• 金额: $ 2.72万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349405
• 关键词: ES; CELL; TRANSPLANTATION; PARKINSON; DISEASE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To test the hypothesis that neural precursor cells differentiated from embryonic stem cells and transplanted into the brain alleviates Parkinsonian symptoms in nonhuman primates. Hemi-parkinsonian symptoms were induced by MPTP injection. Neural precursor cells differentiated from human or rhesus embryonic stem cells were transplanted into the striatum and substantia nigra. Sham control animals received the same surgery, but no neural precursor cells. Results suggested that transplantation of neural precursor cells survived for up to 5 months, transformed into dopamine neurons, and alleviated Parkinsonian symptoms. These preliminary observations show potential use of embryonic stem cells for human clinical treatments. Work presented as an abstract of the 35th Annual Meeting of the Society for Neuroscience. This research used Animal Services and Research Services.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。为了验证神经前体细胞从胚胎干细胞分化并移植到大脑中可以减轻非人类灵长类动物帕金森症状的假设。注射MPTP诱导半帕金森症状。将人或恒河猴胚胎干细胞分化的神经前体细胞移植到纹状体和黑质中。假对照动物接受了同样的手术，但没有神经前体细胞。结果表明，移植神经前体细胞存活长达5个月，转化为多巴胺神经元，减轻帕金森症状。这些初步观察结果显示胚胎干细胞在人类临床治疗中的潜在应用。研究成果作为神经科学学会第35届年会上的摘要发表。这项研究使用了动物服务和研究服务。