BioCurrents Research Center

生物电流研究中心

• 批准号: 6995221
• 负责人: PETER JS SMITH
• 金额: $ 122.52万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6995221
• 关键词: BioCurrents; Research; Center

DESCRIPTION (Adapted from the Applicant's abstract): The overall objective of the BRC initiative is to provide technologies suitable to resolve the functional complexity of the living cell with emphasis on diffusive boundary layers surrounding cells and tissues and correlating the data to the activity of the cell in sub-cellular domains. That initiative requires a continuous development of electrochemical micro-sensors and their applications for detection of important biological molecules through collaborative research projects. This proposal is a continuation of previous research efforts in scope of sensor speed, selectivity and "poisoning" by compounds used in experimental conditions. Major improvement of the sensor performance is claimed in sensor construction. The applicants plan to pursue the sensor construction with a commercial initiative -BioCurrents Research Inc. (BRI) - assuming successful funding of Phase II STTR award or to continue independently. Furthermore, it is planned to continue the development of the BioKelvin probe now renamed to the Bioelectric Field Imager (BFI) device with a goal of clinical application to skin disease within a collaborative work with General Medicine. There are 4 specific aims within the 4A: 1; (1) to continue investigation of ISE in "self-referencing mode" (Seris), (2) to continue development of amperometric -redox based electrodes in self-referencing mode (Sera) (a) by continuing further development of existing electrodes and (b) by initiating development of application of new sensors design -sol-gels and Os gels, (3) to continue development and innovation in hardware and software support, and (4) to improve production of the Whalen design amperometric O2 sensor.

描述（改编自申请人的摘要）：BRC计划的总体目标是提供适合解决活细胞功能复杂性的技术，重点关注细胞和组织周围的扩散边界层，并将数据与亚细胞域中的细胞活动相关联。该倡议需要通过合作研究项目不断开发电化学微传感器及其在检测重要生物分子方面的应用。该提案是先前在传感器速度、选择性和实验条件下使用的化合物“中毒”范围内的研究工作的延续。传感器性能的重大改进在于传感器结构。 申请人计划通过商业计划 - BioCurrents Research Inc. (BRI) 来进行传感器建设 - 假设第二阶段 STTR 资助成功或继续独立进行。此外，计划继续开发 BioKelvin 探针，现已更名为生物电场成像仪 (BFI) 设备，目标是与 General Medicine 合作，将其临床应用于皮肤病。 There are 4 specific aims within the 4A: 1; (1) 继续在“自参考模式”(Seris) 下研究 ISE，(2) 在自参考模式 (Sera) 下继续开发基于电流氧化还原的电极 (a) 继续进一步开发现有电极，(b) 开始开发新传感器设计 - 溶胶-凝胶和 Os 凝胶的应用，(3) 继续在硬件和软件支持方面进行开发和创新，以及 (4) 改进生产 Whalen design amperometric O2 sensor.