Trace Elements and Cardiovascular Disease (CVD) Risks Factors Among Young Adults

微量元素与年轻人心血管疾病 (CVD) 风险因素

• 批准号: 7425908
• 负责人: Ka Kahe
• 金额: $ 21.94万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7425908
• 关键词: African American; Age; Atherosclerosis; Blood; Blood Pressure; C-reactive protein; Calcium; Cardiovascular Diseases; Carotid Atherosclerotic Disease; Caucasians; Caucasoid Race; Clinical; Coronary artery; Development; Evolution; Future; Human; Hypertension; Inflammation; Inflammatory; Interleukin-6; Knowledge; Life; Life Style; Longitudinal Studies; Mass Spectrum Analysis; Measures; Medial; Metabolic syndrome; Neutron Activation Analysis; Participant; Pattern; Plasma; Research Personnel; Risk; Risk Factors; Role; Sampling; Structure of nail of toe; Thick; Trace Elements; Woman; aged; cardiovascular disorder risk; cyclophosphamide/doxorubicin/lomustine protocol; environmental intervention; interest; men; young adult

DESCRIPTION (provided by applicant): Growing evidence suggests that some trace elements may be associated with sub-clinical atherosclerosis and other cardiovascular disease (CVD) risk factors including blood markers of inflammation, hypertension, and metabolic syndrome. However, the longitudinal associations of trace elements in early life with the evolution of CVD risk factors are largely unknown. The overall objective of this project is to examine concentrations of several trace elements in toenails in relation to the development of CVD risk factors and sub-clinical atherosclerosis among young adults in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, which is an ongoing multi-center longitudinal study involving African American and Caucasian young men and women. A total of 4362 participants, aged 18-30 at baseline in 1985-86, who provided toenail samples at exam year 2, will be included in the analyses. Trace elements will be quantified by using both neutron activation analysis (NAA) and inductively-coupled-plasma mass spectroscopy (ICP-MS). We will examine the trace elements of interest in relation to longitudinally measured markers of sub-clinical atherosclerosis (carotid intimal-medial thickness, [CIMT], coronary artery calcium, [CAC]), inflammatory markers (high sensitivity C-reactive protein, [hs-CRP], interleukin 6, [IL-6]), blood pressure and metabolic syndrome. The findings from this study can advance our knowledge of the roles in humans of trace elements in the development of CVD risk. The information from this project can also help researchers, in future studies identify whether CVD risk factors can be changed by dietary, supplemental, lifestyle or environmental intervention in terms of modifying trace element patterns starting at a young age.

描述（由申请人提供）：越来越多的证据表明，一些微量元素可能与亚临床动脉粥样硬化和其他心血管疾病 (CVD) 危险因素（包括炎症、高血压和代谢综合征的血液标志物）有关。然而，生命早期微量元素与 CVD 危险因素演变的纵向关联在很大程度上尚不清楚。该项目的总体目标是在年轻人冠状动脉风险发展（CARDIA）研究中检查脚趾甲中几种微量元素的浓度与年轻人心血管疾病危险因素和亚临床动脉粥样硬化的关系，该研究是一项正在进行的多中心纵向研究，涉及非裔美国人和白人年轻男女。总共 4362 名参与者（1985-86 年基线年龄为 18-30 岁）将纳入分析，他们在第二年的考试中提供了脚趾甲样本。微量元素将通过中子活化分析 (NAA) 和电感耦合等离子体质谱 (ICP-MS) 进行定量。我们将检查与亚临床动脉粥样硬化纵向测量标记物（颈动脉内膜中层厚度，[CIMT]、冠状动脉钙，[CAC]）、炎症标记物（高敏 C 反应蛋白，[hs-CRP]、白细胞介素 6，[IL-6]）、血压和代谢综合征相关的感兴趣的微量元素。这项研究的结果可以增进我们对微量元素在人类心血管疾病风险发展中的作用的认识。该项目的信息还可以帮助研究人员在未来的研究中确定心血管疾病危险因素是否可以通过饮食、补充剂、生活方式或环境干预来改变，从年轻时就开始改变微量元素模式。

项目成果

An exome array study of the plasma metabolome.

• DOI: 10.1038/ncomms12360
• 发表时间: 2016-07-25
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Rhee EP;Yang Q;Yu B;Liu X;Cheng S;Deik A;Pierce KA;Bullock K;Ho JE;Levy D;Florez JC;Kathiresan S;Larson MG;Vasan RS;Clish CB;Wang TJ;Boerwinkle E;O'Donnell CJ;Gerszten RE
• 通讯作者: Gerszten RE

Longitudinal association between toenail zinc levels and the incidence of diabetes among American young adults: The CARDIA Trace Element Study.

美国年轻人脚趾甲锌水平与糖尿病发病率之间的纵向关联：CARDIA 微量元素研究。

• DOI: 10.1038/srep23155
• 发表时间: 2016
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Park,JongSuk;Xun,Pengcheng;Li,Jing;Morris,SteveJ;Jacobs,DavidR;Liu,Kiang;He,Ka
• 通讯作者: He,Ka

Dietary magnesium intake and risk of metabolic syndrome: a meta-analysis.

• DOI: 10.1111/dme.12537
• 发表时间: 2014-11
• 期刊: Diabetic medicine : a journal of the British Diabetic Association
• 作者: Dibaba DT;Xun P;Fly AD;Yokota K;He K
• 通讯作者: He K

Low- and moderate- levels of arsenic exposure in young adulthood and incidence of chronic kidney disease: Findings from the CARDIA Trace Element Study.

• DOI: 10.1016/j.jtemb.2020.126657
• 发表时间: 2021-01
• 期刊: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
• 作者: Yang K;Chen C;Brockman J;Shikany JM;He K
• 通讯作者: He K

Magnesium intake and the metabolic syndrome: epidemiologic evidence to date.

• DOI: 10.1111/j.1559-4564.2006.05702.x
• 发表时间: 2006-01-01
• 期刊: Journal of the cardiometabolic syndrome
• 作者: He, Ka;Song, Yiqing;Chen, Youguo
• 通讯作者: Chen, Youguo