LONGITUDINAL STUDY OF OCULAR COMPLICATIONS OF AIDS (SOCA)

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项研究将是一项多中心的前瞻性研究，招募了大约2000名艾滋病患者。至少一只眼睛的最佳矫正视力至少为20/100，并根据1993年疾病预防控制中心艾滋病诊断标准诊断为艾滋病的患者将有资格参加。主要关注的结果是巨细胞病毒性视网膜炎和其他眼部并发症的发生率以及死亡率。次要关注的结果包括艾滋病相关眼病（如视网膜脱离）的后遗症发生率、治疗并发症的发生率以及眼部并发症的长期结果（如视觉功能、生活质量）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study will be a multicenter, prospective study enrolling a cohort of about 2,000 patients with AIDS. Patients with best-corrected visual acuity of at least 20/100 in at least one eye and with a diagnosis of AIDS according to the 1993 CDC diagnostic criteria for AIDS will be eligible for enrollment. The outcome of primary interest are incidence of CMV retinitis and other ocular complications, and mortality. Outcomes of secondary interest include incidence of sequelae of AIDS related eye disease (e.g., retinal detachments), incidence of complications of therapy, and long-term outcomes of ocular complications (e.g., visual function, quality of life).