EFFECT OF CHROMIUM ON PROGRESSION OF INSULIN RESISTANCE

铬对胰岛素抵抗进展的影响

• 批准号: 7562197
• 负责人: PETER J HAVEL
• 金额: $ 8.2万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562197
• 关键词: Attenuated; Bioavailable; Biological Availability; Body fat; Chromium; Chromium Picolinate; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Daily; Development; Diet; Dyslipidemias; Ensure; Funding; Grant; High Density Lipoproteins; Human; Hypertriglyceridemia; Inflammatory; Institution; Insulin; Insulin Resistance; Intake; Link; Lipids; Long-Term Effects; Macaca mulatta; Metabolic; Metabolic Diseases; Metabolic syndrome; Modeling; Muscle; Numbers; Obesity; Plasma; Research; Research Personnel; Resources; Source; Supplementation; Syndrome; Tissues; Triglycerides; United States National Institutes of Health; Weight; cardiovascular risk factor; design; feeding; improved; insulin sensitivity; nicotinate; nonhuman primate; oxidation; prevent; respiratory; sugar; sweetened beverage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the effect of long term supplementation with Chromium in the progression of Metabolic Syndrome in obese rhesus monkeys fed sugar sweetened beverages. Chromium supplementation has been demonstrated to improve insulin sensitivity in some, but not all, studies conducted in insulin-resistant subjects. Chromium has also been suggested to have effects to improve plasma lipid profiles. This study examines the long-term (1 year) effects of chromium supplementation to prevent or attenuate the progression of insulin resistance and dylipidemia in a nonhuman primate model of the Metabolic (insulin resistance) Syndrome. The development of insulin resistance in obese rhesus monkeys shares similar features with the progression of metabolic disease in humans. We have previously demonstrated that providing obese rhesus monkeys with a sugar-sweetened beverage daily in combination with ad libitum access to their normal diet for 1 year results in modest weight and body fat gain accompanied by a rapid progression of insulin resistance and dyslipidemia (elevated triglyceride and reduced HDL levels). The use of this model in which rigorous control and compliance with diet and chromium intake can be ensured will allow us to determine the effects of long-term chromium supplementation in the progression of the metabolic syndrome. In addition, we will assess the effects of chromium on a number of lipid and inflammatory parameters associated with insulin resistance and cardiovascular risk. We will also determine the effects of chromium on two parameters closely linked to muscle insulin action; muscle triglyceride content and whole body substrate oxidation (respiratory quotient). Although chromium picolinate is the most widely used form of chromium supplement, some studies suggest that the nicotinate form of chromium is more bioavailable and therefore more effective. Therefore, we will compare the bioavailability (tissue chromium status) and the efficacy of chromium picolinate and chromium nicotinate in the amelioration of diet-induced insulin resistance and dyslipidemia. The results of these studies will provide valuable information for the design and implementation of new clinical studies examining the effects of chromium supplements in the management of metabolic syndrome in humans.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：确定长期补充铬对喂养含糖饮料的肥胖恒河猴代谢综合征进展的影响。在一些（但不是全部）针对胰岛素抵抗受试者进行的研究中，补充铬已被证明可以提高胰岛素敏感性。铬也被认为具有改善血浆脂质谱的作用。本研究在代谢（胰岛素抵抗）综合征的非人灵长类动物模型中检验了补充铬对预防或减轻胰岛素抵抗和血脂异常进展的长期（1 年）影响。肥胖恒河猴胰岛素抵抗的发展与人类代谢疾病的进展具有相似的特征。我们之前已经证明，每天为肥胖恒河猴提供含糖饮料，同时随意摄入正常饮食一年，会导致体重和体脂适度增加，并伴有胰岛素抵抗和血脂异常（甘油三酯升高和高密度脂蛋白水平降低）的快速进展。使用该模型可以确保严格控制和遵守饮食和铬的摄入量，这将使我们能够确定长期补充铬对代谢综合征进展的影响。此外，我们将评估铬对与胰岛素抵抗和心血管风险相关的许多脂质和炎症参数的影响。我们还将确定铬对与肌肉胰岛素作用密切相关的两个参数的影响；肌肉甘油三酯含量和全身底物氧化（呼吸商）。尽管吡啶甲酸铬是最广泛使用的铬补充剂形式，但一些研究表明烟酸盐形式的铬具有更高的生物利用度，因此更有效。因此，我们将比较吡啶甲酸铬和烟酸铬的生物利用度（组织铬状态）和改善饮食引起的胰岛素抵抗和血脂异常的功效。这些研究的结果将为新的临床研究的设计和实施提供有价值的信息，以检查铬补充剂在人类代谢综合征管理中的作用。