EFFECT OF APAP ON PLASMA GLUTATHIONE AND CYSTEINE

APAP 对血浆谷胱甘肽和半胱氨酸的影响

• 批准号: 7376405
• 负责人: Dean Paul Jones
• 金额: $ 5.08万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376405
• 关键词: EFFECT; APAP; PLASMA; GLUTATHIONE; CYSTEINE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this research are to evaluate toxicological perturbations of metabolism due to complex chemical mixtures and diet-chemical interactions using high resolution 1H-NMR spectroscopy. These experiments are designed to provide data on the extent of normal variation in metabolic profiles within healthy individuals and, in combination with key glutathione redox measurements, will show whether changes due to chemical exposure and diet can be discriminated.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是使用高分辨率1H-NMR光谱法评价由于复杂化学混合物和饮食-化学相互作用引起的代谢毒理学扰动。这些实验旨在提供健康个体代谢谱正常变化程度的数据，并结合关键的谷胱甘肽氧化还原测量，将显示是否可以区分化学暴露和饮食引起的变化。