EFFECT OF APAP ON PLASMA GLUTATHIONE AND CYSTEINE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this research are to evaluate toxicological perturbations of metabolism due to complex chemical mixtures and diet-chemical interactions using high resolution 1H-NMR spectroscopy. These experiments are designed to provide data on the extent of normal variation in metabolic profiles within healthy individuals and, in combination with key glutathione redox measurements, will show whether changes due to chemical exposure and diet can be discriminated.