THE NATURAL HISTORY OF PEANUT AND NUT PROTEIN ALLERGY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。花生和树坚果是儿童和成人中最容易引起过敏的食物，对这些食物的过敏反应可能很严重，有时甚至致命。花生和坚果过敏，不像对牛奶、鸡蛋、大豆和小麦过敏，很少会消失；然而，最近的一项研究发现，长大后不再对花生过敏的儿童比例明显高于之前的估计。虽然纵向研究表明，在生命早期发现的牛奶、鸡蛋和大豆过敏通常会消退，但只有一份关于花生过敏的公开报告表明，这种过敏可以“长大”。本研究的目的是验证我们的假设，即10-20%的早发性花生或树坚果过敏儿童在以后的生活中会变得耐受，并证实我们之前的观察结果，即CAP-RAST FEI （Pharmacia & Upjohn Diagnostics）抗原特异性IgE抗体的定量是临床反应性的良好预测指标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Peanuts and tree nuts are the most allergenic foods in children and adults, and allergic reactions to these foods can be severe and sometimes fatal. Peanut and nut allergy, unlike allergy to milk, egg, soy and wheat, are rarely outgrown; however, a recent study found a significantly higher percentage of children outgrew their peanut allergy than previously appreciated. While longitudinal studies have shown that milk, egg and soy allergies detected early in life often resolve, only one published report on peanut allergy suggests that this allergy can be "outgrown". The purpose of this study is to test our hypothesis that 10-20% of children with early onset peanut or tree nut allergy become tolerant later in life, and confirm our previous observations that quantitation of antigen-specific IgE antibodies by CAP-RAST FEI (Pharmacia & Upjohn Diagnostics) is a good predictor of clinical reactivity.