HIGH RISK BREAST CANCER CLINIC

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。高危乳腺癌诊所（HRBCC）本身不是一项研究，而是一项研究资源，旨在招募来自乳腺癌和卵巢癌频率增加的家庭的个体。这些人的数据和生物标本随后可用于研究。HRBCC是由美国国家癌症研究所资助的六个国际网站之一，其中包括乳腺癌研究合作家庭登记处（CFRBCS）。在当地，受试者由整个地区的医生确定和转介，或从以前的高危家庭研究中转介。参加HRBCC的个人提供有关家族史，医疗和人口统计信息以及癌症状态和治疗的数据。获得血液样品，从中获得血浆、DNA和淋巴母细胞系。受试者接受遗传教育和咨询，并在适当时进行遗传检测。已入组866例受试者。携带乳腺癌易感基因突变的其他个体将在未来4年内入组。HRBCC为希望研究乳腺癌各个方面的当地和国际研究人员提供生物标本和数据。当地研究者通过亨斯迈癌症研究所申请获得HRBCC资源。机构外的调查人员通过向CFRBCS咨询委员会提出申请，可以获得HRBCC和其他五个地点的样本和数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The High Risk Breast Cancer Clinic (HRBCC) is not itself a research study but is a research resource designed to recruit individuals from families with an increased frequency of breast and ovarian cancer. Data and biospecimens from these individuals are then made available for research studies. The HRBCC is one of six international sites funded by the National Cancer Institute which comprise the Cooperative Family Registry for Breast Cancer Studies (CFRBCS). Locally, subjects are identified and referred by physicians throughout the region or are referred from previous studies of at-risk families. Individuals enrolling in the HRBCC provide data about family history, medical and demographic information, and cancer status and treatment. Blood samples are obtained, from which plasma, DNA, and lymphoblast cell lines are obtained. Subjects receive genetic education and counseling, and genetic testing when appropriate. Eight hundred and sixty-six subjects have been enrolled. Additional individuals who carry mutations in breast cancer predisposition genes will be enrolled over the next 4 years. The HRBCC provides biospecimens and data to both local and international researchers wishing to study various aspects of breast cancer. Local investigators apply through the Huntsman Cancer Institute for access to HRBCC resources. Investigators from outside the institution gain access to samples and data from the HRBCC and the other five sites by applying to the Advisory Committee of the CFRBCS.