EFFECT OF EDUCATION AND DRUG PRESENTATION ON EFFICACY OF MONTELUKAST IN ASTHMA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项由研究者发起的多中心方案，旨在研究全国600名患者的安慰剂效应。轻度哮喘患者随机接受Singulair或安慰剂治疗，并进一步随机接受强化“非药物”干预或不干预治疗。第五组接受常规护理。非药物干预措施包括使用蓝色大胶囊（相对于白色小胶囊）、多媒体教育计划和护士协调员的护理人员处方。随访6周。主要终点是肺活量计测量的峰值流量。该研究不要求安慰剂组因为入组而减少基线治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an investigator-initiated multicenter protocol to study the placebo effect in 600 patients nationwide. Patients with mild asthma are randomized to Singulair or placebo and further randomized to enhanced "non-drug" interventions or no intervention in a 2 x 2 format. A fifth group receives usual care. Non-drug interventions include the use of big blue capsules (versus small white ones), multimedia educational programs, and caregiver prescriptions for nurse coordinators. Patients are followed for 6 weeks. The primary endpoint is peak flow as measured by spirometry. The study does not require the placebo group to have any reduction in their baseline treatment because of enrollment.