CDC MENTORED PUBLIC HEALTH RESEARCH SCIENTIST DEVELOPMENT AWARD

青少年作为证人或受害者遭受暴力的情况越来越普遍， 对青年产生的一系列负面后果，包括参与艾滋病毒/艾滋病风险的可能性增加 行为，如避孕套使用率低，与多个伴侣发生性关系，以及参与性行为 在酒精或其他物质影响下的行为。公共卫生的重要性 不应低估迄今为止关于暴力暴露和艾滋病毒/艾滋病危险行为的研究;然而， 这项研究的几个方法论的局限性，最明显的是依赖于回顾性，交叉， 分段或短期纵向设计，以及只关注一种类型的暴力 暴露或一种HIV/AIDS危险行为，显著限制了这项工作对HIV/AIDS的政策影响 预防工作。利用定量方法的进步，结合方法的严谨性， 虐待儿童和虐待儿童纵向研究（LONGSCAN），一组合作的虐待儿童和虐待儿童的研究， 在美国5个地点的1,354名儿童之后，拟议的K01项目 旨在研究受虐待青少年暴力暴露的不同发展轨迹， 特定轨迹在多大程度上更好地预测参与艾滋病毒/艾滋病风险行为的程度， 青少年，以及在缓和这些轨迹的背景变量的作用。反过来， 拟议的分析，以及有暴力风险的青年家庭的反馈， 为他们服务的从业人员将为制定一个手册化的艾滋病毒/艾滋病预防计划提供信息 针对长期和累积遭受暴力的高风险青年家庭。预防 该计划和相关手册将作为后续赠款申请的基础， 目的是在随机临床试验中初步测试预防方案的有效性。符合健康 疾病控制和预防中心概述的保护目标，研究计划，培训 K01提供的活动和指导将增加准备参加以下活动的青少年人数： 成为健康、安全、独立和有生产力的社会成员，解决以下两个主要公共问题： 与青少年儿童的相关性，美国青少年暴力暴露率的上升以及相关的 从事与艾滋病毒/艾滋病传播有关的行为的风险。

Adolescent exposure to violence, either as a witness or victim, is increasingly common and associated with a wide range of negative outcomes for youth, including increased likelihood of engaging in HIV/AIDS risk behaviors, such as low rates of condom use, having sex with multiple partners, and engaging in sexual behaviors while under the influence of alcohol or other substances. The public health importance of research to date on violence exposure and HIV/AIDS risk behaviors should not be minimized; however, several methodologicallimitations of this research, most notably the reliance on retrospective, cross- sectional, or short-term longitudinal designs, as well as the narrow focus on only one type of violence exposure or one HIV/AIDS risk behavior, significantly limit the policy implications of this work for HIV/AIDS prevention efforts. Utilizing advances in quantitative methods, in combination with the methodological rigor of the Longitudinal Studies of Child Abuse and Neglect (LONGSCAN), a set of collaborating child abuse and neglect projects following 1,354 children in 5 locations acrossthe United States, the proposed K01 project aims to examine different developmental trajectories of violence exposure among maltreated youth, the extent to which specific trajectories better predict levels of involvement in HIV/AIDS risk behaviors in adolescence, and the role of contextual variables in moderating these trajectories. In turn, findings from the proposed analyses,as well as feedback from families of youth at-risk for violence exposure and the practitioners who serve them, will inform the development of a manualized HIV/AIDS prevention program targeting families of youth at high-risk for cumulative and chronic exposure to violence. The prevention program and associated manual will serve as the foundation for a subsequent grant application which will aim to pilot test the efficacy of the prevention program in a randomized clinical trial. Consistent with Health Protection Goals outlined by the Centers for Disease Control and Prevention, the research plan, training activities, and mentorship afforded by this K01 will increase the number of adolescents who are prepared to be healthy, safe, independent and productive members of society by addressing two major public issues of relevance for adolescent children, the rising rates of youth violence exposure in the U.S. and the associated risk for engaging in behaviors linked with the transmission of HIV/AIDS.