Environmental Factors in Cardiovascular Disease

心血管疾病的环境因素

• 批准号: 7474590
• 负责人: Joel Daniel Kaufman
• 金额: $ 15.46万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7474590
• 关键词: Acetylcysteine; Acute; Address; Air Pollutants; Air Pollution; Antioxidants; Atherosclerosis; Award; Binding; Biometry; Breathing; Cardiology; Cardiovascular Diseases; Cardiovascular system; Cell Adhesion Molecules; Cell surface; Chronic; Collaborations; Data Analyses; Databases; Diesel Exhaust; Discipline; Dose; Endothelial Cells; Environmental Engineering technology; Environmental Health; Environmental Medicine; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Exposure to; F2-Isoprostanes; Fibrinolysis; Functional disorder; Goals; Health; Homeostasis; Hour; Human; Hygiene; Hypersensitivity; Impaired health; Individual; Inflammation; Intercellular Adhesion Molecules; Intercellular adhesion molecule 1; Joints; Left; Lipid Peroxidation; Long-Term Effects; Lung diseases; Mediating; Medical Students; Mentors; Mentorship; Modeling; Morbidity - disease rate; Occupational; Oxidants; Oxidative Stress; Particulate; Particulate Matter; Plasma; Play; Pollution; Population; Pulmonology; Research; Research Infrastructure; Research Personnel; Role; Selectins; Source; Stress; Students; Supplementation; Toxicology; Training; Training Programs; Universities; Washington; ascorbate; base; brachial artery; cohort; health science research; insight; mortality; novel; particle; patient oriented; patient oriented research; programs; response; success; trafficking; translational approach

DESCRIPTION (provided by applicant) The goal of this proposed midcareer investigator award is to expand training in multi-disciplinary research focused on the environmental health sciences at the University of Washington. Through collaborations with several ongoing training programs, the candidate, Joel D. Kaufman, MD, MPH, will expand current research efforts and develop a mentoring program with trainees from several relevant disciplines. This program will integrate experimental, epidemiologic, and translational approaches to the role of environmental factors in cardiovascular disease. The proposed research is a continuation of two thematically related projects from Dr. Kaufman's ongoing research program. Both address the thesis that particulate matter air pollution exerts its effect through systemic oxidative stress and inflammation, which in turn results in endothelial dysfunction. The first project studies the effect of diesel exhaust particulate on endothelial function in controlled inhalational exposures, addressing mechanistic hypotheses to understand the role of systemic oxidative stress. The second project is based in an epidemiological study of air pollution effects on cardiovascular disease, and examines the joint and independent effects of acute and chronic pollution exposures on plasma markers of endothelial activation, oxidative stress, and systemic inflammation in a multi-ethnic population-based cohort. The mentorship program builds on Dr. Kaufman's success in multi-disciplinary research, and aims to provide research mentorship in patient-oriented environmental health sciences research to trainees from a wide variety of disciplines. These will include fellows in occupational and environmental medicine, pulmonary medicine, allergy, and cardiology; medical students; and graduate students in epidemiology, toxicology, occupational and environmental hygiene, and environmental engineering. The program will include a research infrastructure (research assistance, data analysis, and biostatistics) and supervised research mentorship. The University of Washington provides an outstanding setting for collaborative training and patient-oriented research in environmental health sciences.

描述（由申请人提供） 这个提议的职业中期研究者奖的目标是扩大华盛顿大学环境健康科学多学科研究的培训。通过与几个正在进行的培训项目的合作，候选人，乔尔D。考夫曼，医学博士，公共卫生硕士，将扩大目前的研究工作，并制定一个指导计划与学员从几个相关学科。该计划将整合实验，流行病学和转化方法来研究环境因素在心血管疾病中的作用。 拟议的研究是考夫曼博士正在进行的研究计划中两个主题相关项目的延续。 两者都解决了颗粒物空气污染通过全身氧化应激和炎症发挥作用的论点，这反过来又导致内皮功能障碍。第一个项目研究了柴油机尾气颗粒物在受控吸入暴露中对内皮功能的影响，解决了机制假说，以了解全身氧化应激的作用。第二个项目基于空气污染对心血管疾病影响的流行病学研究，并在多种族人群队列中研究急性和慢性污染暴露对内皮活化，氧化应激和全身炎症等血浆标志物的联合和独立影响。 导师计划建立在考夫曼博士在多学科研究方面的成功基础上，旨在为来自各种学科的学员提供以患者为导向的环境健康科学研究方面的研究导师。这些将包括职业和环境医学、肺医学、过敏和心脏病学的研究员;医科学生;以及流行病学、毒理学、职业和环境卫生以及环境工程的研究生。 该计划将包括研究基础设施（研究援助，数据分析和生物统计学）和监督研究导师。华盛顿大学为环境健康科学的合作培训和以患者为导向的研究提供了出色的环境。