Environmental Factors in Cardiovascular Disease

描述(由申请人提供) 这个拟议的职业生涯中期调查员奖的目标是扩大华盛顿大学专注于环境健康科学的多学科研究的培训。通过与几个正在进行的培训项目的合作，候选人Joel D.Kaufman，医学博士，公共卫生硕士，将扩大当前的研究工作，并开发一个与几个相关学科的学员一起的指导计划。该计划将结合实验、流行病学和转化方法，研究环境因素在心血管疾病中的作用。 这项拟议的研究是考夫曼博士正在进行的研究计划中两个主题相关项目的延续。这两篇论文都阐述了颗粒物空气污染通过全身氧化应激和炎症发挥作用，进而导致内皮功能障碍的论点。第一个项目研究柴油机尾气颗粒物在受控吸入暴露中对内皮功能的影响，解决机制假说，以了解全身氧化应激的作用。第二个项目基于空气污染对心血管疾病影响的流行病学研究，并在一个以多种族人群为基础的队列中检查急性和慢性污染暴露对血管内皮细胞激活、氧化应激和全身炎症的血浆标志物的联合和独立影响。 导师计划建立在考夫曼博士在多学科研究方面的成功基础上，旨在为来自不同学科的学员提供以患者为导向的环境健康科学研究方面的研究指导。他们将包括职业和环境医学、肺部医学、过敏和心脏病学的研究员；医学生；以及流行病学、毒理学、职业和环境卫生和环境工程的研究生。该计划将包括研究基础设施(研究援助、数据分析和生物统计学)和监督研究指导。华盛顿大学为环境健康科学方面的协作培训和以患者为中心的研究提供了一个出色的环境。

DESCRIPTION (provided by applicant) The goal of this proposed midcareer investigator award is to expand training in multi-disciplinary research focused on the environmental health sciences at the University of Washington. Through collaborations with several ongoing training programs, the candidate, Joel D. Kaufman, MD, MPH, will expand current research efforts and develop a mentoring program with trainees from several relevant disciplines. This program will integrate experimental, epidemiologic, and translational approaches to the role of environmental factors in cardiovascular disease. The proposed research is a continuation of two thematically related projects from Dr. Kaufman's ongoing research program. Both address the thesis that particulate matter air pollution exerts its effect through systemic oxidative stress and inflammation, which in turn results in endothelial dysfunction. The first project studies the effect of diesel exhaust particulate on endothelial function in controlled inhalational exposures, addressing mechanistic hypotheses to understand the role of systemic oxidative stress. The second project is based in an epidemiological study of air pollution effects on cardiovascular disease, and examines the joint and independent effects of acute and chronic pollution exposures on plasma markers of endothelial activation, oxidative stress, and systemic inflammation in a multi-ethnic population-based cohort. The mentorship program builds on Dr. Kaufman's success in multi-disciplinary research, and aims to provide research mentorship in patient-oriented environmental health sciences research to trainees from a wide variety of disciplines. These will include fellows in occupational and environmental medicine, pulmonary medicine, allergy, and cardiology; medical students; and graduate students in epidemiology, toxicology, occupational and environmental hygiene, and environmental engineering. The program will include a research infrastructure (research assistance, data analysis, and biostatistics) and supervised research mentorship. The University of Washington provides an outstanding setting for collaborative training and patient-oriented research in environmental health sciences.