The UCSD Digestive Diseases Research Development Center

总体描述（由申请人提供）：加州大学圣地亚哥消化疾病研究发展中心（UCSD DDRDC）的目标是提供框架，以促进研究生产力，促进新的研究方向，并鼓励参与成员之间的合作。该中心的主题侧重于从炎症到修复再到转化的病理生理过程的连续性，如肝脏和肠道等消化器官内的疾病进展所强调的那样。该中心支持来自UCSD医学院6个部门的21名既定研究人员和8名初级研究人员，他们分享了对推动炎症修复消化器官转化连续体的调控机制的理解和发现，并将提供可能转化为控制或预防转化进展的疗法的见解。UCSD DDRDC支持三个高度相互关联，以服务为导向的生物医学核心，这将提高成员的研究潜力和生产力。动物模型核心提供动物研究（包括肠道炎症，感染和异种移植模型），繁殖群体支持（包括收购，建立和基因工程小鼠的初始繁殖）的进行和分析的帮助，以及动物研究的建议和培训。该成像核心提供的方法和设计，图像数据采集和利用先进的显微镜获得的图像分析的援助。Imaging Core还提供细胞内离子成像和浓度测定的辅助、采集和分析，这些离子成像和浓度测定在炎症状态下可能会发生显著变化。分子病理学核心通过激光捕获显微镜提供细胞采集和分析方面的帮助，并利用基于荧光的基因表达系统以及利用高密度微阵列提供行为和分析方面的帮助。UCSD DDRDC的三个核心将为成员提供高质量和最先进的实验，增加成员之间的合作活动，并加速初级研究人员的研究发展。UCSD DDRDC协同UCSD消化器官研究人员的强大研究基础，并提供了一个资源丰富的智力环境，以鼓励新的研究思路和相互作用，解决炎症修复转化连续体。

DESCRIPTION, OVERALL (provided by applicant): The University of California San Diego Digestive Disease Research Development Center (UCSD DDRDC) goal is to provide the framework to facilitate research productivity, foster new research directions, and encourage collaborations to form among participating members. The Center's theme focuses on the continuum of pathophysiological processes that progress from inflammation to repair to transformation, as highlighted in the disease progression within digestive organs such as the liver and intestine. The Center supports 21 established investigators and 8 junior investigators from 6 departments within the UCSD School of Medicine who share in the understanding and discovery of regulatory mechanisms that drive the inflammation to repair to transformation continuum in digestive organs, and will provide insights that may translate into therapies to control or prevent progression towards transformation. The UCSD DDRDC supports three highly inter-related, service-oriented biomedical Cores that will increase members research potential and productivity. An Animal Model Core provides assistance in the conduct and analysis of animal studies (including models of intestinal inflammation, infection, and xenotransplantation), breeding colony support (including acquisition, establishment, and intial breeding of genetically-engineered mice), and advice and training in animal research. The Imaging Core provides assistance in the approach and design, image data acquisition, and analysis of images obtained utilizing sophisticated microscopy. The Imaging Core also provides assistance, acquisition, and analysis of intracellular ion imaging and concentration determination that can be markedly altered in inflammatory states. The Molecular Pathobiology Core provides assistance in the acquisition and analysis of cells via laser capture microscopy, and provides assistance in the conduct and analysis utilizing fluorescent-based gene expression systems as well as utilizing high-density microarrays. The three cores of the UCSD DDRDC will provide high quality and state of the art experiments for members, increase collaborative activity among the members, and accelerate growth in research development of junior investigators. The UCSD DDRDC synergizes the strong research base of digestive organ investigators at UCSD, and provides a resource-rich and intellectual environment to embolden novel research ideas and interactions that address the inflammation to repair to transformation continuum.