The UCSD Digestive Diseases Research Development Center

总体描述(由申请者提供)：加州大学圣地亚哥分校消化疾病研究发展中心(UCSD DDRDC)的目标是提供框架，促进研究生产力，培育新的研究方向，并鼓励参与成员之间形成合作。该中心的主题侧重于从炎症到修复再到转化的一系列病理生理过程，如肝脏和肠道等消化器官内的疾病进展所强调的那样。该中心支持来自加州大学圣地亚哥分校医学院6个系的21名资深研究人员和8名初级研究人员，他们分享了对推动炎症修复到消化器官转化连续体的调控机制的理解和发现，并将提供可能转化为控制或防止转化进展的疗法的见解。UCSD DDRDC支持三个高度相关、面向服务的生物医学核心，这将提高成员的研究潜力和生产率。动物模型核心在动物研究(包括肠道炎症、感染和异种移植模型)、繁育群体支持(包括基因工程小鼠的获取、建立和初步繁殖)以及动物研究方面的建议和培训方面提供协助。成像核心在方法和设计、图像数据采集以及利用精密显微镜获得的图像分析方面提供帮助。成像核心还提供细胞内离子成像和浓度测定的辅助、采集和分析，这些在炎症状态下可以显著改变。分子病理生物学核心通过激光捕获显微镜帮助获取和分析细胞，并利用基于荧光的基因表达系统和高密度微阵列提供指导和分析。UCSD DDRDC的三个核心将为成员提供高质量和最先进的实验，增加成员之间的协作活动，并加速初级研究人员的研究发展。UCSD DDRDC协同了UCSD消化器官研究人员的强大研究基础，并提供了一个丰富的资源和智力环境，以鼓励新的研究想法和互动，以解决炎症修复到转化连续体。

DESCRIPTION, OVERALL (provided by applicant): The University of California San Diego Digestive Disease Research Development Center (UCSD DDRDC) goal is to provide the framework to facilitate research productivity, foster new research directions, and encourage collaborations to form among participating members. The Center's theme focuses on the continuum of pathophysiological processes that progress from inflammation to repair to transformation, as highlighted in the disease progression within digestive organs such as the liver and intestine. The Center supports 21 established investigators and 8 junior investigators from 6 departments within the UCSD School of Medicine who share in the understanding and discovery of regulatory mechanisms that drive the inflammation to repair to transformation continuum in digestive organs, and will provide insights that may translate into therapies to control or prevent progression towards transformation. The UCSD DDRDC supports three highly inter-related, service-oriented biomedical Cores that will increase members research potential and productivity. An Animal Model Core provides assistance in the conduct and analysis of animal studies (including models of intestinal inflammation, infection, and xenotransplantation), breeding colony support (including acquisition, establishment, and intial breeding of genetically-engineered mice), and advice and training in animal research. The Imaging Core provides assistance in the approach and design, image data acquisition, and analysis of images obtained utilizing sophisticated microscopy. The Imaging Core also provides assistance, acquisition, and analysis of intracellular ion imaging and concentration determination that can be markedly altered in inflammatory states. The Molecular Pathobiology Core provides assistance in the acquisition and analysis of cells via laser capture microscopy, and provides assistance in the conduct and analysis utilizing fluorescent-based gene expression systems as well as utilizing high-density microarrays. The three cores of the UCSD DDRDC will provide high quality and state of the art experiments for members, increase collaborative activity among the members, and accelerate growth in research development of junior investigators. The UCSD DDRDC synergizes the strong research base of digestive organ investigators at UCSD, and provides a resource-rich and intellectual environment to embolden novel research ideas and interactions that address the inflammation to repair to transformation continuum.