权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Amino Acids, Protein, and BMI in Adults Across Cultures

不同文化背景成年人的氨基酸、蛋白质和体重指数

基本信息

批准号：
7456459
负责人：
Ka Kahe
金额：
$ 18.08万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7456459
关键词：
Adult Age Alanine Amino Acids Animals Arginine Asparagine Aspartic Acid Attention Blood Pressure Body Weight Body mass index Carnosine Chicago China Country Cystine Data Data Sources Databases Diet Dietary Proteins Drug Formulations Excretory function Future Glutamic Acid Glutamine Glycine Goals Health Histidine Hour Individual Intake International Investigation Isoleucine Japan Knowledge Lead Leucine Life Style Literature Longitudinal Studies Lysine Measurement Methionine Mono-S NIH Program Announcements Nutrient Obesity Phenylalanine Population Study Proline Prospective Studies Proteins Public Health Recording of previous events Research Sampling Serine Sodium Glutamate Specimen Study Section Taurine Testing Threonine Time Tryptophan Tyrosine Urine Use of New Techniques Valine Vegetable Proteins Vegetables Weight maintenance regimen Woman clinically significant cost energy balance follow-up improved interest men metabolomics nutrition obesity prevention response urinary

项目摘要

DESCRIPTION (provided by applicant): While interest in protein intake as an approach to lower/maintain body weight has had recent popular and research attention, little is known about associations, cross-sectional or longitudinal, between intakes of specific amino acids (AA) or protein and body mass index (BMI). The overall goal of this project is to assess, in a cost-effective manner using existing databases, relations in individuals of specific AAs and dietary protein with BMI. We propose to study individual AAs (dietary and urinary, respectively) in relation to BMI using data from the International Study of Macro- and Micro-nutrients and Blood Pressure (INTERMAP), a cross-sectional, cooperative, high-quality 17-sample population study of 4,680 men and women ages 40-59 in four countries (China, Japan, U.K., U.S.). We also propose to study the longitudinal associations of dietary protein (total, vegetable and animal) intake with BMI using data from the Chicago Western Electric (WE) Company Study, a longitudinal investigation involving 2,107 men ages 40-55. Data on BMI and 18 dietary AAs from four 24-hour recalls, including alanine, arginine, aspartic acid, cystine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine, and a related compound - mono-sodium glutamate (MSG, from China only), and 18 urinary AAs from one timed 24-hour urine specimen, are available in INTERMAP. Data on protein intake including total, vegetable and animal protein from extensive high-quality two diet history assessments, and sequential BMI measurements for 9 years are available in the WE Study. In addition, other major lifestyle factors and diet/nutrient variables are available in both studies. The proposed study seeks to significantly enhance knowledge on individual AAs, protein and BMI that can contribute to improved nutrition for weight control. The findings from this project can be important for further study of the effects of protein composition on body weight, including research using new techniques (e.g. metabolomics). Overall, this proposed study is a cost-effective approach to dealing with important unanswered questions of public health significance related to obesity. The overall goal of the proposed study is to examine, in a cost-effective manner using existing databases, the association between individuals of specific amino acids and dietary protein with body weight. This project has the potential to improve the current limited knowledge on proteins, amino acids and obesity. It is of great public health and clinical significance as obesity is a major health concern. The findings from this project may lead to new research on obesity prevention.

描述(由申请人提供)：虽然蛋白质摄入量作为一种降低/保持体重的方法最近引起了流行和研究的关注，但对特定氨基酸(AA)或蛋白质摄入量与体重指数(BMI)之间的横向或纵向联系知之甚少。该项目的总体目标是利用现有的数据库，以具有成本效益的方式评估特定AAs和饮食蛋白质与BMI之间的关系。我们建议使用国际宏观和微量营养素与血压研究(INTERMAP)的数据来研究个体AA(分别是饮食和尿液)与BMI的关系。INTERMAP是一项横断面、合作、高质量的17样本人群研究，涉及四个国家(日本、日本、英国和美国)的4,680名年龄在40-59岁的男性和女性。我们还建议使用芝加哥西部电气(WE)公司研究的数据来研究饮食蛋白质(总、蔬菜和动物)摄入量与BMI的纵向关系，这是一项涉及2107名年龄在40-55岁的男性的纵向调查。INTERMAP提供了体重指数和来自四个24小时召回的18种膳食氨基酸的数据，包括丙氨酸、精氨酸、天冬氨酸、胱氨酸、谷氨酸、甘氨酸、组氨酸、异亮氨酸、亮氨酸、赖氨酸、蛋氨酸、苯丙氨酸、脯氨酸、丝氨酸、苏氨酸、色氨酸、酪氨酸和缬氨酸，以及相关化合物谷氨酸单钠(味精，仅来自中国)，以及来自一次定时24小时尿样的18种氨基酸。关于蛋白质摄入量的数据，包括总蛋白、植物蛋白和动物蛋白，来自广泛的高质量两次饮食历史评估，以及连续9年的BMI测量，可在WE研究中获得。此外，其他主要的生活方式因素和饮食/营养变量也在这两项研究中可用。这项拟议的研究旨在显著提高对个体AAs、蛋白质和BMI的了解，这些知识有助于改善营养以控制体重。该项目的发现对于进一步研究蛋白质成分对体重的影响，包括使用新技术(如代谢组学)进行研究具有重要意义。总体而言，这项拟议的研究是一种具有成本效益的方法，可以处理与肥胖有关的重要的公共卫生问题，这些问题尚未得到回答。拟议研究的总体目标是利用现有数据库以成本效益的方式检查特定氨基酸和饮食蛋白质的个体与体重之间的联系。该项目有可能改善目前关于蛋白质、氨基酸和肥胖的有限知识。由于肥胖是一个主要的健康问题，因此它具有重要的公共卫生和临床意义。该项目的发现可能会导致对肥胖预防的新研究。