Serum fatty acids and ischemic stroke in women

描述（由申请人提供）：虽然冠心病（CHD）和缺血性卒中有一些共同的主要风险因素，但关于膳食脂肪和血管疾病风险的有限流行病学数据表明，脂肪酸与缺血性卒中的相关性不同于CHD。脂肪类型与冠心病之间的相关性似乎不适用于缺血性卒中。对这种矛盾现象的一个解释性假设是，不同类型脑动脉的动脉硬化具有不同的因果模式。特别是动脉粥样硬化可能仅涉及大动脉梗死，其他危险因素如血压可能在卒中发生中发挥更重要的作用。然而，缺乏脂肪酸与缺血性卒中及其亚型（包括腔隙性（小动脉）、动脉粥样硬化（大动脉）和心源性栓塞性梗死）相关性的数据。本研究的总体目标是检测绝经后妇女血清脂肪酸与缺血性卒中及其亚型风险之间的关系。一项前瞻性巢式病例对照研究的971例缺血性卒中病例和971匹配对照的妇女健康倡议（WHI）的观察性研究，建议实现的目标。拟议项目计划进行两项主要工作：1）使用先前采集和储存的血液标本评估血清脂肪酸组成; 2）进行统计分析，以实现特定目标和假设。这项研究将填补脂肪酸与缺血性卒中亚型相关知识的差距。该项目的研究结果将有助于识别缺血性卒中高风险人群，并澄清脂肪酸与缺血性卒中风险与CHD风险之间可能存在的差异。本研究旨在探讨绝经后妇女中血清脂肪酸与缺血性卒中及其亚型风险之间的关系。这是一个及时和经济的方法调查中风的风险在绝经后妇女。本研究的数据将为缺血性卒中的病因学提供新的信息，并为饮食原因的新探索提供数据。公共卫生相关性：本研究旨在探讨绝经后妇女中血清脂肪酸与缺血性卒中及其亚型风险之间的关系。这是一个及时和经济的方法调查中风的风险在绝经后妇女。本研究的数据将为缺血性卒中的病因学提供新的信息，并为饮食原因的新探索提供数据。

DESCRIPTION (provided by applicant): While coronary heart disease (CHD) and ischemic stroke share some major risk factors, limited epidemiological data on dietary fats and vascular disease risk indicate that fatty acids have different associations with ischemic stroke than with CHD. The established associations between types of fat and CHD do not appear to apply to ischemic stroke. One explanatory hypothesis for the paradoxical observations is that arteriosclerosis in different types of cerebral arteries has different causal patterns. Particularly, atherosclerosis may only be involved in large artery infarction, and other risk factors such as blood pressure may play more important role in stroke development However, data on the associations of fatty acids and ischemic stroke and its subtypes including lacunar (small artery), atherosclerotic (large artery) and cardioembolic infarction are lacking. The general goal of this study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women. A prospective nested case-control study of 971 ischemic stroke cases and 971 matched controls in the Women's Health Initiative (WHI) Observational Study is proposed to achieve the objectives. Two major endeavors are planned for the proposed project: 1) assess serum fatty acids composition with previously collected and stored blood specimens; and 2) perform the statistical analyses, which undertake the specific aims and hypothesis. The proposed study will fill the gap in knowledge regarding associations of fatty acids and subtypes of ischemic stroke. Findings from this project will potentially help identify people at high risk of ischemic stroke as well as clarify possible differences between fatty acids and risk of ischemic stroke versus risk of CHD. The proposed study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women who are at increased risk of stroke. It is a timely and economical approach for investigating stroke risk in postmenopausal women. The data generated from this study should provide new information on the etiology of ischemic stroke and data for new explorations of dietary causes. PUBLIC HEALTH RELEVANCE: The proposed study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women who are at increased risk of stroke. It is a timely and economical approach for investigating stroke risk in postmenopausal women. The data generated from this study should provide new information on the etiology of ischemic stroke and data for new explorations of dietary causes.