CHARACTERIZATION OF ACYLPHOPHATIDYLGLYCEROLS FROM SALMONELLA TYPHIMURIUM BY TAN

通过 Tan 表征鼠伤寒沙门氏菌中的酰基磷脂酰甘油

• 批准号: 7355211
• 负责人: FONG-FU HSU
• 金额: $ 0.85万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7355211
• 关键词: CHARACTERIZATION; ACYLPHOPHATIDYLGLYCEROLS; SALMONELLA; TYPHIMURIUM; TAN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Acylphosphatidylglycerol (Acyl-PG), a polar lipid class containing three fatty acyl groups, was isolated from Salmonella bacteria and characterized by tander quadrupole and quadrupole ion-trap mass spectrometric methods with electrospray ionization. The structural characterization of the acyl-PG with various acyl groups (A-B/C-PG, where A not equal B not equal C) is based on findings that the carboxylate anions (R(x)CO(2)(-)) arrising from sn-2 (R(x)CO(2)(-)) is more abundant than that arising from sn-3'(R(3')CO(2)(-)), which is much more abundatnt than that arising from sn-1 (R(1)CO(2)(-)).

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。酰基磷脂酰甘油（Acylphosphatidylglycerol，Acyl-PG）是从沙门氏菌中分离得到的一种含有3个脂肪酰基的极性脂质，采用Tander四极杆和四极杆电喷雾离子阱质谱法对其进行了表征。含不同酰基的酰基-PG的结构表征（A-B/C-PG，其中A不等于B不等于C）是基于以下发现：由sn-2（R（x）CO（2）（-））产生的羧酸根阴离子（R（x）CO（2）（-））比由sn-3 '（R（3'）CO（2）（-））产生的羧酸根阴离子（R（x）CO（2）（-））更丰富，它比sn-1（R（1）CO（2）（-））产生的要丰富得多。