New catalytic modes for carbon-carbon bond forming reactions

碳-碳键形成反应的新催化模式

• 批准号: EP/P009514/1
• 负责人: Timothy Donohoe
• 金额: $ 44.44万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP009514%2F1
• 关键词: New; catalytic; modes; carbon; bond

Chemistry is a dynamic subject that is at the centre of many different scientific advances. Organic chemistry is concerned with the reactivity of carbon in all its different forms and can be viewed as the chemistry taking place within living things. Chemists are constantly looking for new ways of designing and building molecules (synthetic chemistry is essentially molecular architecture) and this proposal describes a short and powerful new way of making valuable molecules using a new catalytic system that works, uniquely, in combination with an unusual solvent. The molecules at the heart of the proposal are cyclic four-membered carbon containing compounds which are rare in organic chemistry and are underdeveloped and underexplored. We will bring together the different disciplines of organic chemistry, electrochemistry and computational chemistry to develop this area and to provide new applications, insight and synergies.The novel chemistry proposed here will provide a new, efficient and powerful way of making cyclic compounds using catalysis to control all aspects of the structures of the products formed: this will be of great benefit to both academia and industry who will be able to make interesting molecules (some that were otherwise inaccessible) in new ways. Given all of the above, it is imperative that we have novel, efficient and powerful methods for making new compounds so that we can study and use them. In addition, the development and application of new catalytic systems and solvent combinations is also important because catalysis makes chemical reactions run faster, and become cleaner with less waste: this is clearly a good thing for industry and also for the environment. The real advantage of this proposal is the combination of three different disciplines to study and understand a worthwhile chemical problem.

化学是一门充满活力的学科，是许多不同科学进步的中心。有机化学关注的是碳在所有不同形式中的反应性，可以被视为生物体内发生的化学。化学家们一直在寻找设计和构建分子的新方法（合成化学本质上是分子结构），这项提议描述了一种简短而强大的新方法，可以使用一种新的催化系统来制造有价值的分子，这种催化系统与一种不寻常的溶剂结合使用。该提案的核心分子是环状四元含碳化合物，这在有机化学中很少见，并且不发达和探索不足。我们将汇集有机化学、电化学和计算化学的不同学科来发展这一领域，并提供新的应用、见解和协同作用。这里提出的新化学将提供一种新的、有效的和强大的方法，利用催化作用来控制所形成的产物结构的各个方面：这对学术界和工业界都有很大的好处，他们将能够以新的方式制造有趣的分子（有些分子是无法用其他方法获得的）。鉴于上述所有情况，我们必须有新的，有效的和强大的方法来制造新的化合物，以便我们可以研究和使用它们。此外，新的催化体系和溶剂组合的开发和应用也很重要，因为催化剂使化学反应更快，更清洁，废物更少：这显然对工业和环境都是一件好事。这个建议的真实的优点是结合三个不同的学科来研究和理解一个有价值的化学问题。