Portable optogenetics/two-photon imaging instrument for in vivo brain studies
Portable optogenetics/two-photon imaging instrument for in vivo brain studies
批准号:
9254840
负责人:
Youbo Zhao
金额:
$22.99万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-04-04 至 2018-04-03
关键词:
AchievementAnimal TestingAnimalsBehaviorBrainCalciumComplexCrystallizationDevelopmentDevicesDimensionsEngineeringEvaluationFiberFluorescenceGelGenerationsGenetically Modified AnimalsGoalsGovernmentHandHeadHumanIllinoisImageImaging DeviceImaging technologyLaboratoriesLasersLateralLightLightingMechanicsMicroscopeNeuronsNeurosciencesOpticsPatternPerformancePersonsPhasePhysiologic pulsePlayProteinsResearchResearch PersonnelResolutionSepharoseSourceSystemTechnologyTestingUniversitiesbasecostdensitydesignexperienceflexibilityfluorescence imagingin vivoinnovative technologiesinstrumentneural circuitnext generationnovel strategiesoptical imagingoptogeneticsparticlephotonicsphysical scienceportabilityprogramsprototyperelating to nervous systemsuccesstooltwo-photon
中文摘要
项目总结/文摘
英文摘要
Project Summary/Abstract
Physical Sciences Inc. (PSI) and University of Illinois at Urbana Champaign (UIUC) propose to develop
and commercialize an affordable optogenetics/two-photon (2P) imaging instrument that will enable
simultaneous manipulation and recording of neuronal activity in genetically modified animals. The goal of
this project is to bring this highly desirable tool into the hands of neuroscientists and expand their capability
for investigating and deciphering neural circuits underpinning complex brain function and behavior.
Currently, the access of neuroscientists to this technology is profoundly limited, because of both high cost,
which is often beyond the affordability of neuroscience researchers, and difficulty of use on live animals
(bench-top mounted microscope platforms are cumbersome for in vivo brain studies involving living
animals).
To reach this goal, PSI will use innovative technologies, including dispersion-compensated laser delivery
through a fiber cord, coherent supercontinuum (SC) generation in a photonic crystal fiber that enables the
use of multiple excitation wavelengths selected for optimal excitation of calcium-sensitive fluorescent
proteins, and beam control with spatial light modulators, etc. The achievement of this goal will be supported
by the expertise and a proven track record of developing the next generation biomedical devices of the
investigators from PSI, as well as the engineering and neuroscience expertise of the leading research
groups at University of Illinois at Urbana-Champaign.
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会议论文
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海外基金