Dietary Soy/Isoflavones and Urinary Estrogen Metabolites

膳食大豆/异黄酮和尿液雌激素代谢物

• 批准号: 6631443
• 负责人: MARILYN TSENG
• 金额: $ 8.5万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6631443
• 关键词: DNA damage; biomarker; breast neoplasms; cancer prevention; cancer risk; clinical research; dietary constituent; estrogen analog; estrogens; female; flavones; human subject; nutrient intake activity; nutrition related tag; ovary neoplasms; phytoestrogens; questionnaires; soybeans; steroid hormone metabolism; urinalysis

DESCRIPTION (provided by applicant): Research on potential cancer-protective effects of soy and isoflavones has led to an increase in the availability and consumption of soy products in the US. Yet conflicting scientific evidence raises the concern that high levels of intake might actually increase breast cancer risk. Whether current levels of soy and soy isoflavone intake are sufficiently high to affect breast cancer risk is unknown largely because of a lack of convenient, current, and validated methods of assessing intake. The objectives of the proposed study are to (1) evaluate the validity of overnight urine samples as a method of assessing soy isoflavone intake, and (2) examine associations between soy/isoflavone intake and urinary estrogen metabolites. Participants will be drawn from a program at Fox Chase Cancer Center for women at high breast or ovarian cancer risk. The study will include 50 women with either very high or low soy intake based on questionnaire data. Participants will complete a soyfood questionnaire and provide four 24-hour urine specimens over a one month period, with overnight samples collected in separate containers. Urines will be analyzed for isoflavones, primarily daidzein and genistein, and for estrogen metabolites including 2-, 4-, and 16alpha-hydroxy estrogens. Isoflavone levels in overnight urine samples will be evaluated for validity by examining their correlations with isoflavone levels in 24-hour urine specimens. We will use multiple linear regression to examine associations of soy/isoflavone intake with urinary estrogen metabolites. The proposed research will provide useful information towards assessment of soy/isoflavone intake in a non-Asian sample. It is also an opportunity to add to limited knowledge on soy/isoflavone intake and its association with urinary estrogen metabolites as markers of breast cancer risk. Findings from this research will contribute information towards a soy supplementation trial to evaluate modification of soy/isoflavone intake as a means of reducing risk of breast cancer, a disease for which few preventive measures are available.

描述(由申请人提供)： 大豆和异黄酮潜在的防癌作用研究已取得进展 增加了美国大豆产品的供应和消费。 然而，相互矛盾的科学证据引发了人们的担忧，即高水平的 摄入量实际上可能会增加患乳腺癌的风险。目前的水平是否 大豆和大豆异黄酮的摄入量足够高，足以影响乳腺癌 风险未知在很大程度上是因为缺乏方便、最新和 经过验证的评估摄入量的方法。拟议研究的目标 是为了(1)评估过夜尿样作为一种方法的有效性 评估大豆异黄酮类的摄入量，以及(2)检查 大豆/异黄酮类摄入量和尿雌激素代谢物。参与者将是 摘自福克斯·蔡斯癌症中心为乳房或乳房过高的女性提供的一个项目 卵巢癌风险。这项研究将包括50名患有非常高或极高症状的女性。 根据调查问卷数据，大豆摄入量较低。参与者将完成一份 豆类食品问卷调查，并提供4个24小时尿样 一个月的时间内，过夜样本收集在单独的容器中。小便 将分析异黄酮类，主要是大豆苷元和染料木素，以及 雌激素代谢物包括2-、4-和16α-羟基雌激素。异黄酮类 过夜尿液样本的水平将通过检查来评估有效性 它们与24小时尿样中异黄酮量的相关性。我们会 使用多元线性回归检验大豆/异黄酮类成分的相关性 摄入尿液中的雌激素代谢物。这项拟议的研究将为评估非亚洲人大豆/异黄酮的摄入量提供有用的信息。 样本。这也是一个机会，可以增加关于以下方面的有限知识 大豆/异黄酮类摄入及其与尿雌激素代谢产物的关系 乳腺癌风险的标志物。这项研究的发现将有助于 关于大豆补充剂试验的信息，以评估对 大豆/异黄酮类作为降低乳腺癌风险的一种方法 几乎没有可用的预防措施。