Peromyscus Laboratory Models for Biomedical Research

用于生物医学研究的 Peromyscus 实验室模型

• 批准号: 7217241
• 负责人: Michael Ray Felder
• 金额: $ 19.77万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7217241
• 关键词: American; Area; Attention; Babesiosis; Basic Science; Behavior; Biological Preservation; Biology; Biomedical Research; Bioterrorism; Breeding; Chromosome Mapping; Chromosome Painting; Communicable Diseases; Count; Cryopreservation; Databases; Deer Mouse; Development; Disease; Ehrlichiosis; Embryo Transfer; Emerging Communicable Diseases; Epidemiology; Facility Construction Funding Category; Figs - dietary; Fluorescent in Situ Hybridization; Funding; Genetic; Genomic Imprinting; Genomics; Habitats; Hantavirus; House mice; Human; Hybrids; Internet; Investigation; Laboratories; Laboratory mice; Lyme Disease; Mammals; Modeling; Molecular Cytogenetics; Movement Disorders; Mus; North America; Peromyscus; Phylogenetic Analysis; Physiological; Physiology; Plague; Positioning Attribute; Process; Publications; Range; Rattus; Rattus norvegicus; Research; Research Personnel; Resources; Rest; Rodent; Role; Social Behavior; Source; Study models; Support of Research; Syndrome; Technology; United States; White-Footed Mouse; Xenobiotic Metabolism; base; environmental toxicology; genetic technology; improved; microorganism; mortality; mutant; pathogen; positional cloning; sperm cell

DESCRIPTION (provided by applicant): The Peromyscus Genetic Stock Center is a unique facility. The Stock Center is unmatched for its role as a reliable source of disease free peromyscines, and unmatched for the variety of Peromyscus species and mutants available. The Stock Center is utilized by researchers in a wide range of fields, including human infectious disease. Peromyscines came to the Nation's attention in recent years for their role as the primary reservoir of two emerging infectious disease microorganisms. One of these, hantavirus, causes a disease with near 40% mortality, and is on the list of potential bioterrorism agents. The other one is the etiological agent of Lyme disease, a debilitating disease which counts 15,000 new cases annually. Stock Center resources are used extensively by investigators studying these and other diseases such as Ehrlichiosis, babesiosis and plague. Other research areas benefiting from Stock Center resources include the mechanism and cure of repetitive movement disorders, the genetics of disrupted genomic imprinting, the physiological basis of social behavior, and environmental toxicology. To continue supporting these research endeavors the Stock Center proposes: 1) to continue providing peromyscines for biomedical and related research, 2) to promote the species and its advantages, and 3) to improve the usefulness of Peromyscus as a laboratory model. Funds are requested to enable development of the sperm cryopreservation technology to provide a more economical means of storing some of the rare mutants maintained by the Stock Center. Funds are also requested to support the construction of a Peromyscus genomics database, and to use fluorescence in situ hybridization to globally determine regions of homology between Mus and Peromyscus, thereby expediting development of a linkage map.

描述（由申请人提供）： Peromyscus遗传储备中心是一个独特的设施。该库存中心是无与伦比的作用，作为一个可靠的来源，疾病免费peromyscines，并无与伦比的各种Peromyscus物种和突变体可用。股票中心是利用研究人员在广泛的领域，包括人类传染病。Peromyscines近年来引起了国家的注意，因为它们是两种新兴传染病微生物的主要储存库。其中之一是汉坦病毒，它导致的疾病死亡率接近40%，并被列入潜在的生物恐怖主义制剂名单。另一种是莱姆病的病原体，这是一种使人衰弱的疾病，每年有15，000例新病例。库存中心的资源被研究这些和其他疾病，如埃里希体病，巴贝西虫病和鼠疫的研究人员广泛使用。从股票中心资源受益的其他研究领域包括重复性运动障碍的机制和治疗，破坏基因组印记的遗传学，社会行为的生理基础和环境毒理学。为了继续支持这些研究工作，股票中心建议：1）继续为生物医学和相关研究提供peromyscines，2）促进物种及其优势，3）提高Peromyscus作为实验室模型的有用性。 要求提供资金，以便能够发展精子冷冻保存技术，为储存中心保存的一些稀有突变体提供更经济的储存手段。还要求提供资金，以支持建立一个Peromyscus基因组数据库，并利用荧光原位杂交技术全面确定小鼠和Peromyscus之间的同源区域，从而加快绘制连锁图。