Peromyscus Laboratory Models for Biomedical Research

描述(由申请人提供)： Permyscus基因储备中心是一个独特的设施。该库存中心作为无病霉菌的可靠来源是无与伦比的，也是无与伦比的菌种和可用突变体的多样性。股票中心被包括人类传染病在内的广泛领域的研究人员利用。近年来，由于作为两种新出现的传染病微生物的主要储存库，Permyscins引起了国家的关注。其中一种是汉坦病毒，它会导致一种死亡率接近40%的疾病，并被列入潜在的生物恐怖主义因子名单。另一种是莱姆病的病原体，莱姆病是一种使人衰弱的疾病，每年新增病例15,000例。股票中心的资源被研究埃立克体病、巴贝斯虫病和鼠疫等这些疾病和其他疾病的调查人员广泛使用。其他受益于股票中心资源的研究领域包括重复运动障碍的机制和治疗、被破坏的基因组印记的遗传学、社会行为的生理基础和环境毒理学。为了继续支持这些研究工作，库存中心建议：1)继续为生物医学和相关研究提供Permyscus；2)推广Permyscus及其优势；3)提高Permyscus作为实验室模型的实用性。 需要资金支持精子冷冻保存技术的发展，以提供一种更经济的方法来存储由库存中心维护的一些稀有突变。还要求提供资金，以支持建立一个Permyscus基因组数据库，并使用荧光原位杂交技术在全球范围内确定小鼠和Permyscus之间的同源区域，从而加快连锁图的开发。

DESCRIPTION (provided by applicant): The Peromyscus Genetic Stock Center is a unique facility. The Stock Center is unmatched for its role as a reliable source of disease free peromyscines, and unmatched for the variety of Peromyscus species and mutants available. The Stock Center is utilized by researchers in a wide range of fields, including human infectious disease. Peromyscines came to the Nation's attention in recent years for their role as the primary reservoir of two emerging infectious disease microorganisms. One of these, hantavirus, causes a disease with near 40% mortality, and is on the list of potential bioterrorism agents. The other one is the etiological agent of Lyme disease, a debilitating disease which counts 15,000 new cases annually. Stock Center resources are used extensively by investigators studying these and other diseases such as Ehrlichiosis, babesiosis and plague. Other research areas benefiting from Stock Center resources include the mechanism and cure of repetitive movement disorders, the genetics of disrupted genomic imprinting, the physiological basis of social behavior, and environmental toxicology. To continue supporting these research endeavors the Stock Center proposes: 1) to continue providing peromyscines for biomedical and related research, 2) to promote the species and its advantages, and 3) to improve the usefulness of Peromyscus as a laboratory model. Funds are requested to enable development of the sperm cryopreservation technology to provide a more economical means of storing some of the rare mutants maintained by the Stock Center. Funds are also requested to support the construction of a Peromyscus genomics database, and to use fluorescence in situ hybridization to globally determine regions of homology between Mus and Peromyscus, thereby expediting development of a linkage map.